2021
Update on Osteoporosis Screening and Management
Anam AK, Insogna K. Update on Osteoporosis Screening and Management. Medical Clinics Of North America 2021, 105: 1117-1134. PMID: 34688418, DOI: 10.1016/j.mcna.2021.05.016.ChaptersConceptsLimited alcohol intakeNew anabolic therapiesLow bone massDual-energy X-ray absorptiometry measurementsBone mineral densityMetabolic bone diseasePostmenopausal womenAnabolic therapyFragility fracturesMicroarchitectural deteriorationSevere osteoporosisBone healthAlcohol intakeOsteoporosis screeningSmoking cessationVitamin DMineral densityPharmacologic agentsBone massBone diseaseHigh riskAbsorptiometry measurementsGold standardOsteoporosisBone tissue
2017
The Effect of Dietary Glycemic Properties on Markers of Inflammation, Insulin Resistance, and Body Composition in Postmenopausal American Women: An Ancillary Study from a Multicenter Protein Supplementation Trial
Stojkovic V, Simpson CA, Sullivan RR, Cusano AM, Kerstetter JE, Kenny AM, Insogna KL, Bihuniak JD. The Effect of Dietary Glycemic Properties on Markers of Inflammation, Insulin Resistance, and Body Composition in Postmenopausal American Women: An Ancillary Study from a Multicenter Protein Supplementation Trial. Nutrients 2017, 9: 484. PMID: 28492492, PMCID: PMC5452214, DOI: 10.3390/nu9050484.Peer-Reviewed Original ResearchConceptsMarkers of inflammationInsulin resistanceGI/GLBody compositionAncillary studiesLean massPRO groupSignificant associationGlycemic load dietDouble-blind trialFat mass ratioTotal lean massTotal fat massPostmenopausal American womenTrunk lean massAge-related alterationsWhey protein supplementLoad dietInflammatory markersSerum CRPChronic inflammationIL-6Fat massSupplementation trialBone density
2015
Dietary Protein and Vitamin D Intake and Risk of Falls: A Secondary Analysis of Postmenopausal Women from the Study of Osteoporotic Fractures
Larocque SC, Kerstetter JE, Cauley JA, Insogna KL, Ensrud K, Lui LY, Allore HG. Dietary Protein and Vitamin D Intake and Risk of Falls: A Secondary Analysis of Postmenopausal Women from the Study of Osteoporotic Fractures. Journal Of Nutrition In Gerontology And Geriatrics 2015, 34: 305-318. PMID: 26267443, PMCID: PMC4547350, DOI: 10.1080/21551197.2015.1054574.Peer-Reviewed Original ResearchConceptsVitamin D intakeVitamin DD intakePostmenopausal womenOsteoporotic fracturesDietary proteinOdds ratioOlder adultsFood frequency questionnaireRisk of fallsOccurrence of fallsIncident fallsFrequency questionnaireProspective cohortHip fractureMusculoskeletal healthInadequate intakeAdequate intakeOlder womenProtein intakeMuscle massSecondary analysisLogistic regressionIntakeWomen
2011
Calcium Intake in the United States from Dietary and Supplemental Sources across Adult Age Groups: New Estimates from the National Health and Nutrition Examination Survey 2003-2006
Mangano KM, Walsh SJ, Insogna KL, Kenny AM, Kerstetter JE. Calcium Intake in the United States from Dietary and Supplemental Sources across Adult Age Groups: New Estimates from the National Health and Nutrition Examination Survey 2003-2006. Journal Of The Academy Of Nutrition And Dietetics 2011, 111: 687-695. PMID: 21515114, PMCID: PMC3896234, DOI: 10.1016/j.jada.2011.02.014.Peer-Reviewed Original ResearchConceptsDietary calcium intakeCalcium intakeCalcium supplement useSupplement useAdult age groupsNational HealthAge groupsCalcium densityEnergy intakeNutrition Examination Survey respondentsTotal calciumNutrition Examination Survey 2003Nutrition Examination Survey dataAdequate intake standardsSupplemental calcium useMedian energy intakeAge 50 yearsYears age groupRecent National HealthOlder age groupsEnergy intake ratioAge-associated changesCross-sectional analysisBone healthDietary calcium
1998
Dietary protein affects intestinal calcium absorption 1 , 2 – 3
Kerstetter JE, O'Brien KO, Insogna KL. Dietary protein affects intestinal calcium absorption 1 , 2 – 3. American Journal Of Clinical Nutrition 1998, 68: 859-865. PMID: 9771863, DOI: 10.1093/ajcn/68.4.859.Peer-Reviewed Original ResearchConceptsFractional calcium absorptionLow-protein dietUrinary calcium excretionCalcium absorptionDay 4Calcium excretionSecondary hyperparathyroidismDietary proteinDual-stable calcium isotopesGlomerular filtration rateIntestinal calcium absorptionHigh-protein dietCalcitropic hormonesCalcium metabolismAdditional womenFiltration rateIntestinal absorptionDay 5Young womenRandom orderDietHyperparathyroidismExperimental dietsDietary fiberExcretion
1997
Increased circulating concentrations of parathyroid hormone in healthy, young women consuming a protein-restricted diet
Kerstetter J, Caseria D, Mitnick M, Ellison A, Gay L, Liskov T, Carpenter T, Insogna K. Increased circulating concentrations of parathyroid hormone in healthy, young women consuming a protein-restricted diet. American Journal Of Clinical Nutrition 1997, 66: 1188-1196. PMID: 9356538, DOI: 10.1093/ajcn/66.5.1188.Peer-Reviewed Original ResearchConceptsLow-protein dietHigh-protein dietSerum PTHDietary proteinMedium protein dietCyclic adenosine monophosphateDay 4Nephrogenous cyclic adenosine monophosphateYoung womenIntestinal calcium absorptionNegative calcium balanceProtein-restricted dietSerum calcitriolUrinary calciumCalcitropic hormonesHealthy womenParathyroid hormoneBone turnSkeletal healthPTH bioactivityCalcium absorptionCalcium metabolismProtein restrictionRenal mechanismsMineral metabolism
1983
Impaired phosphorus conservation and 1,25 dihydroxyvitamin D generation during phosphorus deprivation in familial hypophosphatemic rickets.
Insogna KL, Broadus AE, Gertner JM. Impaired phosphorus conservation and 1,25 dihydroxyvitamin D generation during phosphorus deprivation in familial hypophosphatemic rickets. Journal Of Clinical Investigation 1983, 71: 1562-1569. PMID: 6306051, PMCID: PMC370362, DOI: 10.1172/jci110912.Peer-Reviewed Original ResearchConceptsFamilial hypophosphatemic ricketsNormal subjectsHypophosphatemic ricketsImmunoreactive parathyroid hormone levelsD plasma levelsNephrogenous cyclic AMPParathyroid hormone levelsGlomerular filtration rateDietary phosphorus deprivationHealthy male volunteersTubular reabsorptive capacityLow phosphorus dietCyclic AMP measurementsMale patientsRenal responseFiltration ratePlasma levelsHormone levelsAbnormal responseMale volunteersReabsorptive capacityPatientsPhosphorus intakePhosphorus dietPhosphate conservation