2014
Supplementing a Low-Protein Diet with Dibasic Amino Acids Increases Urinary Calcium Excretion in Young Women 1,2
Bihuniak JD, Sullivan RR, Simpson CA, Caseria DM, Huedo-Medina TB, O’Brien K, Kerstetter JE, Insogna KL. Supplementing a Low-Protein Diet with Dibasic Amino Acids Increases Urinary Calcium Excretion in Young Women 1,2. Journal Of Nutrition 2014, 144: 282-288. PMID: 24431325, PMCID: PMC3927545, DOI: 10.3945/jn.113.185009.Peer-Reviewed Original ResearchConceptsIntestinal calcium absorptionLow-protein dietCalcium absorptionDual-stable calcium isotopesYoung womenUrinary calcium excretionDietary proteinControl diet periodAmino acid L-arginineHigh-protein dietAmino acid L-tryptophanCalcium excretionDiet periodClinical trialsSupplementation periodL-arginineDay 5Control dietRandom orderPhysiologic rangeDietTrialsWomenPossible benefitsL-tryptophan
2013
Increasing dietary protein selectively upregulates the DMT1 isoform that contains an iron responsive element
Thomas C, Yao G, O'Brien K, Kerstetter J, Insogna K. Increasing dietary protein selectively upregulates the DMT1 isoform that contains an iron responsive element. The FASEB Journal 2013, 27: lb284-lb284. DOI: 10.1096/fasebj.27.1_supplement.lb284.Peer-Reviewed Original ResearchIntestinal iron absorptionIron absorptionDietary proteinProtein dietMRNA expressionWhole-body iron homeostasisDuodenum of ratsDMT1 mRNA expressionBody iron homeostasisGenetic absenceExperimental animalsLevel of expressionResponsive elementBrush border membraneRatsIron-responsive elementRecent dataDietCritical regulatorIron homeostasisBorder membraneSignificant changesExpressionIron importerAnimalsThe effect of selective amino acid supplementation on calcium absorption during a low protein diet
Bihuniak J, Sullivan R, Simpson C, Caseria D, O'Brien K, Kerstetter J, Insogna K. The effect of selective amino acid supplementation on calcium absorption during a low protein diet. The FASEB Journal 2013, 27: lb283-lb283. DOI: 10.1096/fasebj.27.1_supplement.lb283.Peer-Reviewed Original ResearchLow-protein dietIntestinal Ca absorptionCa absorptionProtein dietProtein intakeDietary protein intakeHigh-protein dietAmino acid supplementationCalcium absorptionAcid supplementationDay 5Dibasic amino acidsAA supplementationYoung womenControl dietRandom orderPhysiologic rangeDietary proteinIntakeDietSupplementationAmino acidsAromatic amino acidsCa economyLys supplementation
2011
Dietary protein upregulates fractional intestinal iron absorption and directly increases DMT1 transcript and protein expression
Cucchi C, Gaffney‐Stomberg E, Sun B, O'Brien K, Kerstetter J, Insogna K. Dietary protein upregulates fractional intestinal iron absorption and directly increases DMT1 transcript and protein expression. The FASEB Journal 2011, 25: lb193-lb193. DOI: 10.1096/fasebj.25.1_supplement.lb193.Peer-Reviewed Original ResearchProtein dietDietary proteinProtein expressionCaco-2 BBe cellsIntestinal Fe absorptionFe absorption studiesIntestinal iron absorptionTranscript expressionAmino acid-free mediumDMT1 protein levelsAmino acid treatmentDMT1 protein expressionProtein doseIron absorptionBBE cellsIron deficiencyAcid-free mediumRatsProtein levelsDietDMT1 transcriptsAmino acidsFe absorptionWestern analysisKey regulator
2010
A High Protein Diet Induces Intestinal Iron Transporter Expression and Improves Iron Absorption in Rats
Cucchi C, Gaffney‐Stomberg E, Sun B, Kerstetter J, Insogna K. A High Protein Diet Induces Intestinal Iron Transporter Expression and Improves Iron Absorption in Rats. The FASEB Journal 2010, 24: 229.1-229.1. DOI: 10.1096/fasebj.24.1_supplement.229.1.Peer-Reviewed Original ResearchDietary proteinIron absorptionTransporter expressionHigh casein dietExpression of DMT1Iron transporter expressionFe absorptionVs. 5Kruskal-Wallis testMicroarray screenCasein dietMineral homeostasisLevel of expressionProtein dietRatsLittle dataDMT1 expressionQ-PCRDietBalance studiesExpressionHomeostasisGroupDMT1CYBRD1
2007
Dietary protein increases intestinal calcium absorption and improves bone balance: An hypothesis
Kerstetter J, Gaffney E, O'Brien K, Caseria D, Insogna K. Dietary protein increases intestinal calcium absorption and improves bone balance: An hypothesis. International Congress Series 2007, 1297: 204-216. DOI: 10.1016/j.ics.2006.08.027.Peer-Reviewed Original ResearchBone mineral densityIntestinal calcium absorptionHigh-protein dietUrinary calciumBone lossCalcium absorptionProtein dietAccelerated bone lossMost cross-sectional studiesDietary proteinCross-sectional studyLow-protein dietBone turnoverBone resorptionMineral densityBone balanceCalcium studiesCalcium retentionSalutary effectsBone originPrincipal outcomeDietSignificant reductionCalciumResorption
2006
Meat and Soy Protein Affect Calcium Homeostasis in Healthy Women 1 , 2
Kerstetter JE, Wall DE, O’Brien K, Caseria DM, Insogna KL. Meat and Soy Protein Affect Calcium Homeostasis in Healthy Women 1 , 2. Journal Of Nutrition 2006, 136: 1890-1895. PMID: 16772455, DOI: 10.1093/jn/136.7.1890.Peer-Reviewed Original ResearchConceptsIntestinal calcium absorptionUrinary calciumCalcium absorptionLow-protein dietHealthy womenCalcium homeostasisHigher protein interventionNet acid excretionSubset of subjectsHigh-protein dietSoy interventionParathyroid hormoneExperimental periodSerum concentrationsAcid excretionSoy dietAcute declineWomen 1Calcium bioavailabilityRandom orderDietary proteinMeat dietDietSoy proteinIntervention
2004
The Impact of Dietary Protein on Calcium Absorption and Kinetic Measures of Bone Turnover in Women
Kerstetter JE, O’Brien K, Caseria DM, Wall DE, Insogna KL. The Impact of Dietary Protein on Calcium Absorption and Kinetic Measures of Bone Turnover in Women. The Journal Of Clinical Endocrinology & Metabolism 2004, 90: 26-31. PMID: 15546911, DOI: 10.1210/jc.2004-0179.Peer-Reviewed Original ResearchConceptsHigh-protein dietUrinary calciumBone turnoverCalcium absorptionDual-stable calcium isotopesAdditional urinary calciumIntestinal calcium absorptionHealthy womenStable calcium isotopesBone balanceNonsignificant trendSkeletal resorptionCalcium kineticsAcid loadBone originProtein-induced effectsLevels of proteinRandom orderDietary proteinDietHypercalciuriaWomenExperimental dietsSignificant reductionCalciumHigh Protein Diets, Calcium Economy, and Bone Health
Kerstetter J, O'Brien K, Insogna K. High Protein Diets, Calcium Economy, and Bone Health. Topics In Clinical Nutrition 2004, 19: 57-70. DOI: 10.1097/00008486-200401000-00010.Peer-Reviewed Original ResearchHigh-protein dietProtein dietDecrease bone densityUrinary calcium excretionDietary proteinHigh dietary proteinCalcium excretionUrinary calciumBone healthSkeletal healthCalcium economyBone resorptionBone densityLong-term consequencesDietBoneSignificant scientific dataPhysiological mechanismsHealthHumansExcretionResorptionProtein
1998
Dietary protein affects intestinal calcium absorption 1 , 2 – 3
Kerstetter JE, O'Brien KO, Insogna KL. Dietary protein affects intestinal calcium absorption 1 , 2 – 3. American Journal Of Clinical Nutrition 1998, 68: 859-865. PMID: 9771863, DOI: 10.1093/ajcn/68.4.859.Peer-Reviewed Original ResearchConceptsFractional calcium absorptionLow-protein dietUrinary calcium excretionCalcium absorptionDay 4Calcium excretionSecondary hyperparathyroidismDietary proteinDual-stable calcium isotopesGlomerular filtration rateIntestinal calcium absorptionHigh-protein dietCalcitropic hormonesCalcium metabolismAdditional womenFiltration rateIntestinal absorptionDay 5Young womenRandom orderDietHyperparathyroidismExperimental dietsDietary fiberExcretion
1996
Designing an Outpatient Research Diet to Enhance Dietary Compliance
Caseria D, Gay L, Liskov T, Marshall L, Insogna K, Kerstetter J. Designing an Outpatient Research Diet to Enhance Dietary Compliance. Journal Of The Academy Of Nutrition And Dietetics 1996, 96: a77. DOI: 10.1016/s0002-8223(96)00582-2.Peer-Reviewed Original ResearchDietary complianceCalcium metabolismDietary proteinResearch dietsExperimental dietsUnusual physical activityMedication useHealthy womenMetabolic kitchenOutpatient basisExperimental periodMenstrual periodStudy protocolUrinary nitrogen excretionCaloric intakeResearch dietitianPhysical activityBody weightLevels of proteinRandom orderFood requestsDietDaily log sheetsUrinary nitrogenDietitians
1994
Dietary hypercalciuria in patients with calcium oxalate kidney stones
Burtis W, Gay L, Insogna K, Ellison A, Broadus A. Dietary hypercalciuria in patients with calcium oxalate kidney stones. American Journal Of Clinical Nutrition 1994, 60: 424-429. PMID: 8074077, DOI: 10.1093/ajcn/60.3.424.Peer-Reviewed Original ResearchConceptsCalcium excretionFree dietDietary hypercalciuriaKidney stonesUrinary calcium excretionHigh sodium intakeCalcium oxalate stonesHypercalciuric patientsSodium excretionUnselected patientsDietary sodiumSodium intakeDietary calciumDietary factorsDietary habitsPatientsHypercalciuriaExcretionOxalate stonesDietary proteinDietMultiple regression analysisCalciumStonesIntake