1994
Parathyroid hormone-related protein: evidence for isoform- and tissue-specific posttranslational processing.
Yang KH, dePapp AE, Soifer NE, Dreyer BE, Wu TL, Porter SE, Bellantoni M, Burtis WJ, Insogna KL, Broadus AE. Parathyroid hormone-related protein: evidence for isoform- and tissue-specific posttranslational processing. Biochemistry 1994, 33: 7460-9. PMID: 8003511, DOI: 10.1021/bi00189a054.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsCHO CellsChromatography, AffinityChromatography, High Pressure LiquidCricetinaeCricetulusCulture Media, ConditionedHumansImmunohistochemistryMolecular Sequence DataParathyroid HormoneParathyroid Hormone-Related ProteinPeptide FragmentsProtein Processing, Post-TranslationalProteinsTumor Cells, CulturedConceptsHormone-related proteinCarboxy-terminal fragmentCell linesTissue-specific posttranslational processingRat insulinoma cellsDistinct paracrineHuman PTHrP geneHumoral hypercalcemiaMalignant tumorsAutocrine roleRIN cell linesMidregion fragmentPTHrP isoformsMost human cell linesNonmalignant tissuesPhysiological rationalePTHrP geneInsulinoma cellsChinese hamster ovary cellsHuman cell linesHamster ovary cellsSecretory formCellsOvary cellsPosttranslational processing
1988
In vitro adenylate cyclase-stimulating activity predicts the occurrence of humoral hypercalcemia of malignancy in nude mice.
Weir EC, Insogna KL, Brownstein DG, Bander NH, Broadus AE. In vitro adenylate cyclase-stimulating activity predicts the occurrence of humoral hypercalcemia of malignancy in nude mice. Journal Of Clinical Investigation 1988, 81: 818-821. PMID: 3343341, PMCID: PMC442531, DOI: 10.1172/jci113389.Peer-Reviewed Original ResearchConceptsAdenylate cyclase-stimulating activityNude miceHumoral hypercalcemiaSyndrome of HHMMean tumor sizeReliable predictive markersHuman renal carcinoma cell linesCyclase-stimulating activityCell linesRenal carcinoma cell linesCultured tumor cellsHypercalcemic animalsTumor sizeCarcinoma cell linesPredictive markerBone resorptionTumor extractsTumor cellsMiceNormocalcemic animalsPotential mediatorsHypercalcemiaHHMCell assayMalignancySYNTHETIC AND PARTIALLY-PURIFIED ADENYLATE CYCLASE-STIMULATING PROTEINS FROM TUMORS ASSOCIATED WITH HUMORAL HYPERCALCEMIA OF MALIGNANCY INHIBIT PHOSPHATE TRANSPORT IN A PTH-RESPONSIVE RENAL CELL LINE
SARTORI L, WEIR EC, STEWART AF, BROADUS AE, MANGIN M, BARRETT PQ, INSOGNA KL. SYNTHETIC AND PARTIALLY-PURIFIED ADENYLATE CYCLASE-STIMULATING PROTEINS FROM TUMORS ASSOCIATED WITH HUMORAL HYPERCALCEMIA OF MALIGNANCY INHIBIT PHOSPHATE TRANSPORT IN A PTH-RESPONSIVE RENAL CELL LINE. The Journal Of Clinical Endocrinology & Metabolism 1988, 66: 459-461. PMID: 3339117, DOI: 10.1210/jcem-66-2-459.Peer-Reviewed Original ResearchConceptsAdenylate cyclase-stimulating activityHumoral hypercalcemiaPhosphate metabolismCyclase-stimulating activityCell linesSodium-dependent phosphate transportRenal cell linesEpithelial cell lineTumor productsTumor decreaseRenal epithelial cellsRenal epithelial cell lineAmino acid peptidePhosphate transportHypercalcemiaAnimal tumorsTumorsHuman tumorsEpithelial cellsHHMMalignancyNaPiTInhibitory activityMinutes exposureEpithelial monolayers