2024
A prospective cohort study linking migration, climate, and malaria risk in the Peruvian Amazon – CORRIGENDUM
Gunderson A, Recalde-Coronel C, Zaitchik B, Yori P, Pinedo S, Olortegui M, Kosek M, Vinetz J, Pan W. A prospective cohort study linking migration, climate, and malaria risk in the Peruvian Amazon – CORRIGENDUM. Epidemiology And Infection 2024, 152: e5. PMID: 38214060, PMCID: PMC10789972, DOI: 10.1017/s0950268824000025.Peer-Reviewed Original Research
2023
A prospective cohort study linking migration, climate, and malaria risk in the Peruvian Amazon
Gunderson A, Recalde-Coronel C, Zaitchik B, Yori P, Pinedo S, Olortegui M, Kosek M, Vinetz J, Pan W. A prospective cohort study linking migration, climate, and malaria risk in the Peruvian Amazon. Epidemiology And Infection 2023, 151: e202. PMID: 38031496, PMCID: PMC10753477, DOI: 10.1017/s0950268823001838.Peer-Reviewed Original ResearchMeSH KeywordsHumansMalariaMalaria, FalciparumMalaria, VivaxPeruPlasmodium falciparumPlasmodium vivaxProspective Studies
2022
Culture-Independent Detection and Identification of Leptospira Serovars
Matthias M, Lubar A, Acharige S, Chaiboonma K, Pilau N, Marroquin A, Jayasundara D, Agampodi S, Vinetz J. Culture-Independent Detection and Identification of Leptospira Serovars. Microbiology Spectrum 2022, 10: e02475-22. PMID: 36445143, PMCID: PMC9769591, DOI: 10.1128/spectrum.02475-22.Peer-Reviewed Original ResearchConceptsPublic health importanceProspective studyFatal diseaseHealth importanceOutbreak investigationSequence typingDog urine samplesCulture-independent assaysEnvironmental surveillance studyMultilocus sequence typingPulsed-field gel electrophoresisSurveillance studyGroup IIHuman leptospirosisPrognostic testSpecific real-time qPCRClinical settingGroup ILeptospira serovarsReal-time qPCRDiagnostic testsSerum samplesUrine samplesDiagnostic specificityLeptospirosisDiagnostic method-based underestimation of leptospirosis in clinical and research settings; an experience from a large prospective study in a high endemic setting
Warnasekara J, Srimantha S, Kappagoda C, Jayasundara D, Senevirathna I, Matthias M, Agampodi S, Vinetz J. Diagnostic method-based underestimation of leptospirosis in clinical and research settings; an experience from a large prospective study in a high endemic setting. PLOS Neglected Tropical Diseases 2022, 16: e0010331. PMID: 35377883, PMCID: PMC9009773, DOI: 10.1371/journal.pntd.0010331.Peer-Reviewed Original ResearchMeSH KeywordsAgglutination TestsHumansLeptospiraLeptospirosisProspective StudiesRetrospective StudiesConceptsMicroscopic agglutination testProspective hospital-based studyLeptospirosis casesQuantitative PCRHigh endemic settingHospital-based studyClinical case definitionLarge prospective studiesDisease burden estimatesPublic health burdenStandard diagnostic testMonths of observationUndifferentiated feverAcute leptospirosisProspective studyCase definitionEndemic settingsHealth burdenTimely diagnosisBurden estimatesDiagnostic valueSignificant human mortalityAgglutination testStudy settingDiagnostic tests
2021
Clinical spectrum of endemic leptospirosis in relation to cytokine response
Dahanayaka NJ, Agampodi SB, Seneviratna I, Warnasekara J, Rajapakse R, Ranathunga K, Matthias M, Vinetz JM. Clinical spectrum of endemic leptospirosis in relation to cytokine response. PLOS ONE 2021, 16: e0261025. PMID: 34879100, PMCID: PMC8654203, DOI: 10.1371/journal.pone.0261025.Peer-Reviewed Original ResearchConceptsCytokine responsesLeptospirosis patientsClinical spectrumHigher IL-13 levelsHigher IL-5Acute kidney injuryHigher serum creatinineIL-13 levelsSerum cytokine levelsIL-6 levelsUniversity Teaching HospitalMultiplex cytokine kitKidney injuryLung involvementCytokine levelsSerum creatinineAcute phaseCytokine kitIL-1βAcute samplesConvalescence periodIL-8IL-5Prognostic informationEndemic settings12 Novel clonal groups of Leptospira infecting humans in multiple contrasting epidemiological contexts in Sri Lanka
Jayasundara D, Senavirathna I, Warnasekara J, Gamage C, Siribaddana S, Kularatne SAM, Matthias M, Mariet JF, Picardeau M, Agampodi S, Vinetz J. 12 Novel clonal groups of Leptospira infecting humans in multiple contrasting epidemiological contexts in Sri Lanka. PLOS Neglected Tropical Diseases 2021, 15: e0009272. PMID: 33735202, PMCID: PMC8009393, DOI: 10.1371/journal.pntd.0009272.Peer-Reviewed Original ResearchConceptsClonal groupsAcute kidney injuryL. interrogansMajor clinical challengeGlobal disease threatsLeptospira speciesL. interrogans infectionKidney injuryLiver impairmentCardiovascular involvementL. borgpeterseniiClinical presentationProspective studyClinical severityClinical challengePathogenic Leptospira speciesAnnual epidemicsUbiquitous zoonotic diseaseNew serogroupEpidemiological contextZoonotic diseaseCulture isolationLeptospiral culturesL. weiliiLeptospira diversity
2018
Acceptability of a herd immunity-focused, transmission-blocking malaria vaccine in malaria-endemic communities in the Peruvian Amazon: an exploratory study
White SE, Harvey SA, Meza G, Llanos A, Guzman M, Gamboa D, Vinetz JM. Acceptability of a herd immunity-focused, transmission-blocking malaria vaccine in malaria-endemic communities in the Peruvian Amazon: an exploratory study. Malaria Journal 2018, 17: 179. PMID: 29703192, PMCID: PMC5921293, DOI: 10.1186/s12936-018-2328-z.Peer-Reviewed Original ResearchConceptsTransmission-blocking malaria vaccineTransmission-blocking vaccinesMalaria vaccineMalaria transmission-blocking vaccineMalaria hypoendemic regionMalaria vaccine strategyProspective cohort studyMalaria-endemic communitiesMalaria-endemic regionsPre-validated questionnaireCohort studyVaccine strategiesMalaria infectionMethodsThe studyVaccineMalaria controlMalaria researchMultiple injectionsOne-thirdIndustrialized worldInjectionAcceptabilityCohortInfectionStudy