2024
Effect of spatiotemporal variables on abundance, biting activity and parity of Nyssorhynchus darlingi (Diptera: Culicidae) in peri-Iquitos, Peru
Bickersmith S, Saavedra M, Prussing C, Lange R, Morales J, Alava F, Vinetz J, Gamboa D, Moreno M, Conn J. Effect of spatiotemporal variables on abundance, biting activity and parity of Nyssorhynchus darlingi (Diptera: Culicidae) in peri-Iquitos, Peru. Malaria Journal 2024, 23: 112. PMID: 38641572, PMCID: PMC11031940, DOI: 10.1186/s12936-024-04940-z.Peer-Reviewed Original ResearchConceptsMalaria transmissionBreeding site availabilityPresence of Plasmodium vivaxDry seasonBiting behaviorRisk of malaria transmissionMalaria-endemic regionsHuman malaria casesPlasmodium falciparum sporozoitesRainy seasonCommunity typesNyssorhynchus darlingiRates of parityReal-time PCRAmazonian PeruP. vivaxMalaria casesPlasmodium vivaxHuman landing catchesP. falciparumEffect of seasonMosquito behaviorConclusionsThese dataDaily survivalDarlingi
2023
Natural Infection of Nyssorhynchus darlingi and Nyssorhynchus benarrochi B with Plasmodium during the Dry Season in the Understudied Low-Transmission Setting of Datem del Marañon Province, Amazonian Peru
Conn J, Bickersmith S, Saavedra M, Morales J, Alava F, Rodriguez G, del Aguila Morante C, Tong C, Alvarez-Antonio C, Huanahui J, Vinetz J, Gamboa D. Natural Infection of Nyssorhynchus darlingi and Nyssorhynchus benarrochi B with Plasmodium during the Dry Season in the Understudied Low-Transmission Setting of Datem del Marañon Province, Amazonian Peru. American Journal Of Tropical Medicine And Hygiene 2023, 109: 288-295. PMID: 37364858, PMCID: PMC10397451, DOI: 10.4269/ajtmh.23-0058.Peer-Reviewed Original ResearchConceptsLow transmission settingsAnnual parasite indexEntomological inoculation rateHuman biting rateHuman landing catchesMinistry of HealthMalaria hotspotsInfective bitesPlasmodium vivaxMalaria transmissionLanding catchesPlasmodium falciparumMalaria researchNatural infectionInoculation rateNyssorhynchus darlingiBiting rateRiverine villagesParasite indexBiteVector control unitsDarlingiLoreto DepartmentInfectionVivax
2021
Evolutionary Insights into the Microneme-Secreted, Chitinase-Containing High-Molecular-Weight Protein Complexes Involved in Plasmodium Invasion of the Mosquito Midgut
Kaur H, Pacheco MA, Garber L, Escalante AA, Vinetz JM. Evolutionary Insights into the Microneme-Secreted, Chitinase-Containing High-Molecular-Weight Protein Complexes Involved in Plasmodium Invasion of the Mosquito Midgut. Infection And Immunity 2021, 90: e00314-21. PMID: 34606368, PMCID: PMC8788677, DOI: 10.1128/iai.00314-21.Peer-Reviewed Original ResearchConceptsPeritrophic matrixMosquito midgutNew genomic insightsWeight protein complexesHigh-resolution structural modelingDomain-related proteinEvolutionary insightsInvasion machineryGenomic insightsMicronemal proteinsProtein complexesThree-dimensional structureMosquito interactionsGenomic dataPlasmodium invasionProteolytic milieuMidgut epitheliumWeight complexesAdhesive proteinsOokinetesGeneral mechanismProteinChitinasesMidgutChitinaseA Hetero-Multimeric Chitinase-Containing Plasmodium falciparum and Plasmodium gallinaceum Ookinete-Secreted Protein Complex Involved in Mosquito Midgut Invasion
Patra KP, Kaur H, Kolli SK, Wozniak JM, Prieto JH, Yates JR, Gonzalez DJ, Janse CJ, Vinetz JM. A Hetero-Multimeric Chitinase-Containing Plasmodium falciparum and Plasmodium gallinaceum Ookinete-Secreted Protein Complex Involved in Mosquito Midgut Invasion. Frontiers In Cellular And Infection Microbiology 2021, 10: 615343. PMID: 33489941, PMCID: PMC7821095, DOI: 10.3389/fcimb.2020.615343.Peer-Reviewed Original ResearchConceptsChitin-containing peritrophic matrixHMW complexesMosquito midgut invasionDomain-related proteinNext-generation vaccinesMicronemal proteinsVon Willebrand factorProtein complexesMidgut invasionPeritrophic matrixProteolytic milieuMidgut epitheliumPfCHT1Malaria parasitesSurface enolaseOokinetesPlasmodium falciparumWillebrand factorMidgut wallAdhesive proteinsProteinMass spectrometryShort formSize exclusion chromatography dataMosquito vectors
2018
Complete avian malaria parasite genomes reveal features associated with lineage-specific evolution in birds and mammals
Böhme U, Otto TD, Cotton JA, Steinbiss S, Sanders M, Oyola SO, Nicot A, Gandon S, Patra KP, Herd C, Bushell E, Modrzynska KK, Billker O, Vinetz JM, Rivero A, Newbold CI, Berriman M. Complete avian malaria parasite genomes reveal features associated with lineage-specific evolution in birds and mammals. Genome Research 2018, 28: 547-560. PMID: 29500236, PMCID: PMC5880244, DOI: 10.1101/gr.218123.116.Peer-Reviewed Original ResearchConceptsAvian malaria speciesLTR retrotransposonsHigh-quality draft genome sequenceClades of parasitesComplete LTR retrotransposonsLineage-specific evolutionNovel gene familyOrthologs of genesMalaria parasite genomeAvian malaria parasitesAmino acid divergenceDraft genome sequenceInvasion-related genesAvian lineagesMalaria speciesProtein homologsGene familyMultigene familyPhylogenetic positionTransposable elementsBird speciesParasite genomePhylogenetic analysisGenome sequenceAvian malaria
2004
Plasmodium Ookinete-secreted Proteins Secreted through a Common Micronemal Pathway Are Targets of Blocking Malaria Transmission*
Li F, Templeton TJ, Popov V, Comer JE, Tsuboi T, Torii M, Vinetz JM. Plasmodium Ookinete-secreted Proteins Secreted through a Common Micronemal Pathway Are Targets of Blocking Malaria Transmission*. Journal Of Biological Chemistry 2004, 279: 26635-26644. PMID: 15069061, DOI: 10.1074/jbc.m401385200.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsBlotting, WesternCell MembraneChitinasesCulicidaeCytoplasmDNA, ComplementaryElectrophoresis, Polyacrylamide GelEnzyme-Linked Immunosorbent AssayFluorescent Antibody Technique, IndirectImmunohistochemistryLigandsMalariaMicroscopy, ElectronMicroscopy, FluorescenceMicroscopy, ImmunoelectronMolecular Sequence DataPlasmodiumPlasmodium falciparumProtein BindingProtozoan ProteinsReceptors, Cell SurfaceRecombinant ProteinsSequence Homology, Amino AcidSpecies SpecificityConceptsMicroneme secretory organellesDomain-related proteinP. gallinaceumImmunofluorescence localization studiesMicronemal proteinsIndirect immunofluorescence localization studiesSecretory organellesOokinete stagePlasmodium ookinetesLocalization studiesSporogonic stagesParasite infectivityTransmission-blocking vaccine candidateProteinMalaria parasitesPgCHT1Malaria transmission-blocking vaccine candidateApical endA. aegyptiAnopheles mosquitoesAedes aegyptiPlasmodium gallinaceumVon Willebrand factorImmunological targetsVaccine candidates
2001
Plasmodium ookinete-secreted chitinase and parasite penetration of the mosquito peritrophic matrix
Langer R, Vinetz J. Plasmodium ookinete-secreted chitinase and parasite penetration of the mosquito peritrophic matrix. Trends In Parasitology 2001, 17: 269-272. PMID: 11378031, DOI: 10.1016/s1471-4922(01)01918-3.Peer-Reviewed Original ResearchConceptsMosquito midgutMalaria transmission-blocking strategiesParasite-mosquito interactionsTransmission-blocking strategiesTransmission-blocking drugsGlobal malaria controlPeritrophic matrixMalaria transmissionTransgenic mosquitoesMalaria controlCandidate targetsChitinasesMidgutChitinaseCrucial roleVaccine
2000
Micronemal Transport of Plasmodium Ookinete Chitinases to the Electron-Dense Area of the Apical Complex for Extracellular Secretion
Langer R, Hayward R, Tsuboi T, Tachibana M, Torii M, Vinetz J. Micronemal Transport of Plasmodium Ookinete Chitinases to the Electron-Dense Area of the Apical Complex for Extracellular Secretion. Infection And Immunity 2000, 68: 6461-6465. PMID: 11035760, PMCID: PMC97734, DOI: 10.1128/iai.68.11.6461-6465.2000.Peer-Reviewed Original Research
1995
Cellular mechanisms in the immune response to malaria in Plasmodium vinckei-infected mice
Perlmann H, Kumar S, Vinetz J, Kullberg M, Miller L, Perlmann P. Cellular mechanisms in the immune response to malaria in Plasmodium vinckei-infected mice. Infection And Immunity 1995, 63: 3987-3993. PMID: 7558309, PMCID: PMC173560, DOI: 10.1128/iai.63.10.3987-3993.1995.Peer-Reviewed Original ResearchConceptsImmune miceTh1 responseControl miceIL-4T cellsSpleen cellsIL-4-producing Th2 cellsBALB/c miceTumor necrosis factor alphaAbsence of elevationPlasmodium vinckei vinckeiImmunoglobulin E levelsInfection of miceGamma interferon productionNecrosis factor alphaChabaudi infectionAntigen exposureNonimmune miceImportant protective factorC miceSolid immunityTh2 cellsFactor alphaParasite antigensE levels
1989
Interdependence of CD4+ T cells and malarial spleen in immunity to Plasmodium vinckei vinckei. Relevance to vaccine development.
Kumar S, Good M, Dontfraid F, Vinetz J, Miller L. Interdependence of CD4+ T cells and malarial spleen in immunity to Plasmodium vinckei vinckei. Relevance to vaccine development. The Journal Of Immunology 1989, 143: 2017-23. PMID: 2570802, DOI: 10.4049/jimmunol.143.6.2017.Peer-Reviewed Original ResearchConceptsBALB/c micePlasmodium vinckei vinckeiT cellsImmune miceC miceVivo depletionSpleen cellsNaive BALB/cAthymic nu/nu miceBALB/c nude miceC3H/HeN miceNu/nu miceImmune spleen cellsBALB/cLoss of immunityImmune CD4Malaria AgMalarial spleenVivo CD4Adoptive transferImmune spleenSplenectomized miceMalaria vaccineRodent malariaHeN mice