2022
Malaria transmission structure in the Peruvian Amazon through antibody signatures to Plasmodium vivax
Rosado J, Carrasco-Escobar G, Nolasco O, Garro K, Rodriguez-Ferruci H, Guzman-Guzman M, Llanos-Cuentas A, Vinetz JM, Nekkab N, White MT, Mueller I, Gamboa D. Malaria transmission structure in the Peruvian Amazon through antibody signatures to Plasmodium vivax. PLOS Neglected Tropical Diseases 2022, 16: e0010415. PMID: 35533146, PMCID: PMC9119515, DOI: 10.1371/journal.pntd.0010415.Peer-Reviewed Original ResearchConceptsSerological exposure markersP. vivaxMalaria transmissionAntibody levelsRecent exposureRoutine malaria surveillanceHigher antibody levelsCross-sectional surveyLight microscopySeropositive casesAntibody signaturesPast infectionRisk factorsPrevalence surveyHigher oddsMalaria surveillanceExposure markersElimination effortsSignificant associationSocio-DemographicEpidemiological analysisSerological surveillanceParticular epidemiologyLocal transmissionVivax
2021
PvMSP8 as a Novel Plasmodium vivax Malaria Sero-Marker for the Peruvian Amazon
Villasis E, Garro K, Rosas-Aguirre A, Rodriguez P, Rosado J, Gave A, Guzman-Guzman M, Manrique P, White M, Speybroeck N, Vinetz JM, Torres K, Gamboa D. PvMSP8 as a Novel Plasmodium vivax Malaria Sero-Marker for the Peruvian Amazon. Pathogens 2021, 10: 282. PMID: 33801386, PMCID: PMC7999794, DOI: 10.3390/pathogens10030282.Peer-Reviewed Original ResearchSerological responsePopulation-based cross-sectional surveyRecent malaria exposureMerozoite surface protein 8Non-exposed individualsCross-sectional surveyMalaria control effortsTime of surveyPV exposureMalaria exposureIgG antibodiesTransmission settingsPV infectionGood biomarkerRecent exposurePast monthIgGPlasma samplesProtein 8Second evaluationExposureFirst evaluationIndividualsLuminexCohortHeterogeneity in response to serological exposure markers of recent Plasmodium vivax infections in contrasting epidemiological contexts
Rosado J, White MT, Longley RJ, Lacerda M, Monteiro W, Brewster J, Sattabongkot J, Guzman-Guzman M, Llanos-Cuentas A, Vinetz JM, Gamboa D, Mueller I. Heterogeneity in response to serological exposure markers of recent Plasmodium vivax infections in contrasting epidemiological contexts. PLOS Neglected Tropical Diseases 2021, 15: e0009165. PMID: 33591976, PMCID: PMC7909627, DOI: 10.1371/journal.pntd.0009165.Peer-Reviewed Original ResearchConceptsSerological exposure markersBlood-stage infectionLow transmission settingsP. vivax infectionPlasmodium vivax infectionHigh transmission settingsVivax infectionTransmission settingsAntibody titersAntibody responseExposure markersDifferent transmission intensitiesIgG responsesSerological markersPrevious infectionReceiver Operating Characteristic (ROC) analysisEndemic settingsMalaria eliminationPeruvian cohortOperating characteristics analysisP. vivaxMalaria controlRecent exposureInfectionEpidemiological context