2022
Emulating the GRADE trial using real world data: retrospective comparative effectiveness study
Deng Y, Polley EC, Wallach JD, Dhruva SS, Herrin J, Quinto K, Gandotra C, Crown W, Noseworthy P, Yao X, Lyon TD, Shah ND, Ross JS, McCoy RG. Emulating the GRADE trial using real world data: retrospective comparative effectiveness study. The BMJ 2022, 379: e070717. PMID: 36191949, PMCID: PMC9527635, DOI: 10.1136/bmj-2022-070717.Peer-Reviewed Original ResearchConceptsSecondary outcomesMetformin monotherapyTreatment groupsRetrospective comparative effectiveness studyCox proportional hazards regressionPropensity scoreIncident microvascular complicationsNationwide claims databaseProportional hazards regressionType 2 diabetesComparative effectiveness studiesMacrovascular complicationsMicrovascular complicationsProspective trialAdverse eventsGlycemic controlHospital admissionInsulin glarginePrimary outcomeMedian timeHazards regressionClaims databaseObservational studyInverse propensity scoreEligibility criteria
2012
The Use and Misuse of Thrombolytic Therapy Within the Veterans Health Administration
Keyhani S, Arling G, Williams LS, Ross JS, Ordin DL, Myers J, Tyndall G, Vogel B, Bravata DM. The Use and Misuse of Thrombolytic Therapy Within the Veterans Health Administration. Medical Care 2012, 50: 66-73. PMID: 22182924, DOI: 10.1097/mlr.0b013e3182294092.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAgedAged, 80 and overBrain IschemiaFemaleFibrinolytic AgentsHealth Services MisuseHealth Status IndicatorsHumansMaleMiddle AgedRetrospective StudiesSocioeconomic FactorsStrokeThrombolytic TherapyTime FactorsTissue Plasminogen ActivatorUnited StatesUnited States Department of Veterans AffairsConceptsVHA medical centersTissue plasminogen activatorVeterans Health AdministrationAcute ischemic strokeEligible patientsStroke patientsIschemic strokeSymptom onsetThrombolytic therapyHealth AdministrationStroke symptom onsetAcute stroke patientsIschemic stroke patientsEligible stroke patientsMedical record reviewLow annual volumeThrombolysis deliveryRecord reviewWrong doseVHA systemClinical conditionsMedical CenterEligible veteransEligibility criteriaPatients