2013
Transfer of antigen from human B cells to dendritic cells
Harvey BP, Raycroft MT, Quan TE, Rudenga BJ, Roman RM, Craft J, Mamula MJ. Transfer of antigen from human B cells to dendritic cells. Molecular Immunology 2013, 58: 56-65. PMID: 24309484, PMCID: PMC4234097, DOI: 10.1016/j.molimm.2013.10.013.Peer-Reviewed Original Research
2008
Editing Antigen Presentation: Antigen Transfer between Human B Lymphocytes and Macrophages Mediated by Class A Scavenger Receptors
Harvey BP, Quan TE, Rudenga BJ, Roman RM, Craft J, Mamula MJ. Editing Antigen Presentation: Antigen Transfer between Human B Lymphocytes and Macrophages Mediated by Class A Scavenger Receptors. The Journal Of Immunology 2008, 181: 4043-4051. PMID: 18768860, PMCID: PMC2701691, DOI: 10.4049/jimmunol.181.6.4043.Peer-Reviewed Original ResearchConceptsHuman B lymphocytesB lymphocytesImmune responseB cellsB cell-directed therapiesChronic autoimmune responseCell-directed therapiesScavenger receptor ASpecific B cellsClass A Scavenger ReceptorB cell APCDendritic cellsAntigen transferAutoimmune responseProfessional APCsEfficient APCsAntigen presentationTransfer of AgSpecific AgReceptor AScavenger receptorsMacrophagesLymphocytesAPCReceptors
2005
Naive CD4+ T Cells from Lupus-Prone Fas-Intact MRL Mice Display TCR-Mediated Hyperproliferation Due to Intrinsic Threshold Defects in Activation
Zielinski CE, Jacob SN, Bouzahzah F, Ehrlich BE, Craft J. Naive CD4+ T Cells from Lupus-Prone Fas-Intact MRL Mice Display TCR-Mediated Hyperproliferation Due to Intrinsic Threshold Defects in Activation. The Journal Of Immunology 2005, 174: 5100-5109. PMID: 15814741, DOI: 10.4049/jimmunol.174.8.5100.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigen PresentationAutoimmunityCalcium SignalingCD4-Positive T-LymphocytesCell ProliferationColumbidaeCytochromes cDendritic CellsFas ReceptorGenes, DominantInterleukin-2Lupus Erythematosus, SystemicLymphocyte ActivationMiceMice, Inbred MRL lprMice, Inbred StrainsMice, KnockoutMice, TransgenicPhenotypeReceptor-CD3 Complex, Antigen, T-CellReceptors, Antigen, T-CellSignal TransductionConceptsNaive CD4T cellsSelf-AgAutoreactive T cell activationMRL T cellsT cell toleranceF1 T cellsProximal defectsAnti-CD3 stimulationClass II MHCIL-2 productionT cell activationWild-type CD4Pigeon cytochrome cCell calcium signalingDendritic cellsControl miceMurine lupusObserved hyperactivityII MHCMRL miceIntracellular calciumLow thresholdPeptide AgCD4
1994
The expression of self antigenic determinants: implications for tolerance and autoimmunity
Mamula M, Craft J. The expression of self antigenic determinants: implications for tolerance and autoimmunity. Current Opinion In Immunology 1994, 6: 882-886. PMID: 7536009, DOI: 10.1016/0952-7915(94)90008-6.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigen PresentationAntigen-Presenting CellsAutoantigensAutoimmunityEpitopesHumansImmune ToleranceT-LymphocytesConceptsAntigen-presenting cellsT cellsSelf peptidesSelf antigenic determinantsT cell responsesPathogenesis of autoimmunityMajor histocompatibility moleculesNormal lymphocytesAntigen processingAntigenic determinantsHistocompatibility moleculesAutoimmunityCell surface proteinsNormal pathwayCellsPeptidesLymphocytesPathogenesis