2012
IL-21 Receptor Is Required for the Systemic Accumulation of Activated B and T Lymphocytes in MRL/MpJ-Faslpr/lpr/J Mice
Rankin AL, Guay H, Herber D, Bertino SA, Duzanski TA, Carrier Y, Keegan S, Senices M, Stedman N, Ryan M, Bloom L, Medley Q, Collins M, Nickerson-Nutter C, Craft J, Young D, Dunussi-Joannopoulos K. IL-21 Receptor Is Required for the Systemic Accumulation of Activated B and T Lymphocytes in MRL/MpJ-Faslpr/lpr/J Mice. The Journal Of Immunology 2012, 188: 1656-1667. PMID: 22231702, PMCID: PMC3618484, DOI: 10.4049/jimmunol.1003871.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutoantibodiesAutoimmunityB-LymphocytesCD4-Positive T-LymphocytesCell DifferentiationInterferon-gammaInterleukinsLupus Erythematosus, SystemicLymphatic DiseasesLymphocyte ActivationMiceMice, Inbred MRL lprMice, KnockoutReceptors, Interleukin-21SkinSplenomegalyT-Lymphocyte SubsetsT-Lymphocytes, Helper-InducerConceptsT cell effector subsetsIL-21Effector subsetsIL-21RT cellsHelper cellsSpontaneous germinal center formationIL-21-dependent mannerIL-21 receptorMRL/MpJPlasma cell accumulationGerminal center formationTh cell differentiationSignificant reductionAutoantibody titersAutoantibody productionCytokines IFNImmune activationSystemic autoimmunityJ miceDisease manifestationsT lymphocytesPleiotropic cytokineB cellsDisease pathogenesis
2011
Characterization of different subsets of human follicular helper T (TFH) cells (152.9)
Choi J, Kim S, Lainez B, Craft J. Characterization of different subsets of human follicular helper T (TFH) cells (152.9). The Journal Of Immunology 2011, 186: 152.9-152.9. DOI: 10.4049/jimmunol.186.supp.152.9.Peer-Reviewed Original ResearchFollicular helper T cellsB cell folliclesHelper T cellsTfh cellsT cellsIL-21P-selectin glycoprotein ligand-1IL-4Germinal centersB cellsTonsillar Tfh cellsIL-17 secretionExpression of CD127B cell helpAntigen-specific antibodiesGC B cellsTh17 cellsTfh subsetsPD-1Effector subsetsCell helpTherapeutic targetBCL-6RORC expressionHuman tonsils