A transgenic mouse model expressing exclusively human hemoglobin E: Indications of a mild oxidative stress
Chen Q, Fabry M, Rybicki A, Suzuka S, Balazs T, Etzion Z, de Jong K, Akoto E, Canterino J, Kaul D, Kuypers F, Lefer D, Bouhassira E, Hirsch R. A transgenic mouse model expressing exclusively human hemoglobin E: Indications of a mild oxidative stress. Blood Cells Molecules And Diseases 2012, 48: 91-101. PMID: 22260787, PMCID: PMC3310900, DOI: 10.1016/j.bcmd.2011.12.002.Peer-Reviewed Original ResearchConceptsRed blood cellsKO mouse modelMouse modelElevated zinc protoporphyrin levelsOxidative stressMicrocytic red blood cellsBenign clinical pictureTarget red blood cellsMouse red blood cellsMild oxidative stressDecreased osmotic fragilityRBC oxidative stressGlobin chain synthesisLow MCVLow HbCardiac functionNon-thalassemicClinical symptomsAlternative splicing mutationSplicing mutationClinical pictureReticulocyte levelsTransgenic miceHbE mutationZinc protoporphyrin levels