2013
Plasma Profiles of Matrix Metalloproteinases and Tissue Inhibitors of the Metalloproteinases Predict Recurrence of Atrial Fibrillation Following Cardioversion
Mukherjee R, Akar JG, Wharton JM, Adams DK, McClure CD, Stroud RE, Rice AD, DeSantis SM, Spinale FG, Gold MR. Plasma Profiles of Matrix Metalloproteinases and Tissue Inhibitors of the Metalloproteinases Predict Recurrence of Atrial Fibrillation Following Cardioversion. Journal Of Cardiovascular Translational Research 2013, 6: 528-535. PMID: 23722357, DOI: 10.1007/s12265-013-9471-2.Peer-Reviewed Original ResearchMeSH KeywordsAgedAtrial FibrillationBiomarkersChi-Square DistributionC-Reactive ProteinElectric CountershockFibrosisHeart AtriaHumansLogistic ModelsMatrix MetalloproteinasesMiddle AgedMultivariate AnalysisNatriuretic Peptide, BrainPeptide FragmentsPredictive Value of TestsRecurrenceRisk FactorsTime FactorsTissue Inhibitor of MetalloproteinasesTreatment OutcomeConceptsAF recurrenceMatrix metalloproteinasesMMP-9TIMP-4MMP-3N-terminus pro B type natriuretic peptideHigh-sensitivity C-reactive protein levelsPro-B-type natriuretic peptideTissue inhibitorC-reactive protein levelsB-type natriuretic peptideLevels of MMPsAtrial fibrillation recurrenceNovel biomarker panelAtrial volumeNatriuretic peptideAtrial fibrosisSinus rhythmPredicts RecurrenceBiomarker panelRecurrenceMultivariate analysisPostcardioversionProtein levelsPlasma samples
2007
Presence of asymmetric dimethylarginine gradients across high-grade lesions in patients with coronary artery disease
Joyal D, Leya F, Al-Chekakie M, Arab D, Dieter RS, Morshedi-Meibodi A, Lewis B, Steen L, Fareed J, Hoppenstead D, Akar JG. Presence of asymmetric dimethylarginine gradients across high-grade lesions in patients with coronary artery disease. Coronary Artery Disease 2007, 18: 471-475. PMID: 17700219, DOI: 10.1097/mca.0b013e32818be79c.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionCoronary interventionCoronary lesionsAsymmetric dimethylarginineEndothelial dysfunctionAsymmetric dimethylarginine accumulationAsymmetric dimethylarginine levelsGeneralized endothelial dysfunctionPeripheral venous siteSystemic venous levelsAsymmetric dimethylarginine concentrationsCoronary artery diseaseHigh-grade lesionsNitric oxide synthaseLevels 24 hDimethylarginine levelsDimethylarginine concentrationsCoronary ostiumArtery diseaseSystemic markersVenous levelsCoronary bedFocal injuryOxide synthaseVenous sites