2018
Impaired type I interferon regulation in the blood transcriptome of recurrent asthma exacerbations
Gomez JL, Diaz MP, Nino G, Britto CJ. Impaired type I interferon regulation in the blood transcriptome of recurrent asthma exacerbations. BMC Medical Genomics 2018, 11: 21. PMID: 29486764, PMCID: PMC5830339, DOI: 10.1186/s12920-018-0340-3.Peer-Reviewed Original ResearchConceptsPeripheral blood mononuclear cellsAsthma exacerbationsInterferon-stimulated genesRespiratory infectionsIL-15Vivo cohortToll-like receptor 2STAT1 responseRecurrent asthma exacerbationsAcute asthma exacerbationPro-inflammatory moleculesType I interferon regulationBlood mononuclear cellsPro-inflammatory signatureTranscriptomic signaturesType I interferonFold changeAdult asthmaAcute phaseMononuclear cellsImmunologic genesExacerbationIndependent cohortReceptor 2I interferon
2016
Airway Secretory microRNAome Changes during Rhinovirus Infection in Early Childhood
Gutierrez M, Gomez J, Perez G, Pancham K, Val S, Pillai D, Giri M, Ferrante S, Freishtat R, Rose M, Preciado D, Nino G. Airway Secretory microRNAome Changes during Rhinovirus Infection in Early Childhood. PLOS ONE 2016, 11: e0162244. PMID: 27643599, PMCID: PMC5028059, DOI: 10.1371/journal.pone.0162244.Peer-Reviewed Original ResearchConceptsRV infectionHuman bronchial epithelial cellsAirway secretionsExtracellular vesiclesCause of asthma exacerbationsAirways of young childrenHuman RV infectionsNasal airway secretionsHsa-miR-155Air-liquid interfaceRegulates antiviral immunityMonitor respiratory conditionsSecretion of extracellular vesiclesModify gene expressionAirways of individualsPotential biological relevanceBronchial epithelial cellsAge-matched controlsInnate immune responseDevelopment of asthmaBioinformatics toolsGene datasetsGenetic communicationNoncoding RNA moleculesRNA molecules