2023
Alveolar Vascular Remodeling in Nonspecific Interstitial Pneumonia: Replacement of Normal Lung Capillaries with COL15A1-Positive Endothelial Cells.
Schupp J, Manning E, Chioccioli M, Kamp J, Christian L, Ryu C, Herzog E, Kühnel M, Prasse A, Kaminski N, Jonigk D, Homer R, Neubert L, Ius F, stringJustet A, Hariri L, Seeliger B, Welte T, Knipe R, Gottlieb J. Alveolar Vascular Remodeling in Nonspecific Interstitial Pneumonia: Replacement of Normal Lung Capillaries with COL15A1-Positive Endothelial Cells. American Journal Of Respiratory And Critical Care Medicine 2023, 208: 819-822. PMID: 37552025, PMCID: PMC10563189, DOI: 10.1164/rccm.202303-0544le.Peer-Reviewed Original ResearchWhen Development of the Alveolar Gas Exchange Unit Fails: Universal Single-Cell Lessons from Rare Monogenic Disorders
Schupp J, Kaminski N. When Development of the Alveolar Gas Exchange Unit Fails: Universal Single-Cell Lessons from Rare Monogenic Disorders. American Journal Of Respiratory And Critical Care Medicine 2023, 208: 652-654. PMID: 37555730, PMCID: PMC10515565, DOI: 10.1164/rccm.202307-1271ed.Commentaries, Editorials and Letters
2022
A Morphomolecular Approach to Alveolar Capillary Dysplasia
Kamp J, Neubert L, Ackermann M, Stark H, Plucinski E, Shah H, Janciauskiene S, Bergmann A, Schmidt G, Welte T, Haverich A, Werlein C, Braubach P, Laenger F, Schwerk N, Olsson K, Fuge J, Park D, Schupp J, Hoeper M, Kuehnel M, Jonigk D. A Morphomolecular Approach to Alveolar Capillary Dysplasia. American Journal Of Pathology 2022, 192: 1110-1121. PMID: 35649494, DOI: 10.1016/j.ajpath.2022.05.004.Peer-Reviewed Original ResearchConceptsAlveolar capillary dysplasiaHigh prevalencePersistent pulmonary arterial hypertensionPulmonary arterial hypertension groupC motif chemokine receptor 4CXCR4 ligand CXCL12Pulmonary arterial hypertensionEndothelial tyrosine kinase receptorHypoxia-inducible factor-1αChemokine receptor 4Anti-angiogenic agentsIntussusceptive angiogenesisArterial hypertensionHypertension groupTyrosine kinase receptorsFatal outcomeHealthy controlsReceptor 4Ligand CXCL12Vascular remodelingMicrovascular corrosion castsACD groupMicrovascular morphologyFactor-1αExome sequencing
2019
Single-cell connectomic analysis of adult mammalian lungs
Raredon MSB, Adams TS, Suhail Y, Schupp JC, Poli S, Neumark N, Leiby KL, Greaney AM, Yuan Y, Horien C, Linderman G, Engler AJ, Boffa DJ, Kluger Y, Rosas IO, Levchenko A, Kaminski N, Niklason LE. Single-cell connectomic analysis of adult mammalian lungs. Science Advances 2019, 5: eaaw3851. PMID: 31840053, PMCID: PMC6892628, DOI: 10.1126/sciadv.aaw3851.Peer-Reviewed Original ResearchConceptsTissue homeostasisMammalian lungSingle-cell RNA sequencing techniquesAdult mammalian lungRNA sequencing techniquesCell-cell interactionsSequencing techniquesKey pathwaysAlveolar type IFunctional roleCell typesCell populationsRegenerative medicineHomeostatic mechanismsHomeostasisFine architectureFunctional lung tissueIncomplete understandingMajor roleType ITissueRegulationPathwayAlveolar cell populationsDistal lung