Respiratory virus–induced EGFR activation suppresses IRF1-dependent interferon λ and antiviral defense in airway epithelium
Ueki IF, Min-Oo G, Kalinowski A, Ballon-Landa E, Lanier LL, Nadel JA, Koff JL. Respiratory virus–induced EGFR activation suppresses IRF1-dependent interferon λ and antiviral defense in airway epithelium. Journal Of Experimental Medicine 2013, 210: 1929-1936. PMID: 23999497, PMCID: PMC3782052, DOI: 10.1084/jem.20121401.Peer-Reviewed Original ResearchMeSH KeywordsErbB ReceptorsHumansInterferon Regulatory Factor-1Interferon-gammaProtein Kinase InhibitorsRespiratory MucosaVirus DiseasesVirus InternalizationConceptsEpithelial epidermal growth factor receptorViral infectionHost responseInnate antiviral host responsesEGFR activationIFN-λ productionIFN-λ signalingAntiviral immune responseImportance of IFNType III IFNsAntiviral defenseAntiviral host responseEpidermal growth factor receptorGrowth factor receptorSignificant IFNTyrosine kinase receptorsInterferon λNovel therapiesAirway epitheliumIFN regulatory factor-1Immune responseFuture therapiesViral pathogenesisAntiviral responseIFN