2024
Racial/Ethnic Disparities in Aortic Valve Replacement Among Medicare Beneficiaries in the United States, 2012-2019
Gupta A, Mori M, Wang Y, Pawar S, Vahl T, Nazif T, Onuma O, Yong C, Sharma R, Kirtane A, Forrest J, George I, Kodali S, Chikwe J, Geirsson A, Makkar R, Leon M, Krumholz H. Racial/Ethnic Disparities in Aortic Valve Replacement Among Medicare Beneficiaries in the United States, 2012-2019. The American Journal Of Medicine 2024, 137: 321-330.e7. PMID: 38190959, PMCID: PMC11019903, DOI: 10.1016/j.amjmed.2023.12.026.Peer-Reviewed Original ResearchAortic valve replacementRace/ethnicityValve replacementAortic stenosisWhite patientsMedicare beneficiariesSurgical aortic valve replacement (SAVR) proceduresCross-sectional cohort studyAortic valve replacement proceduresAortic stenosis treatmentRacial/Ethnic DisparitiesValve replacement proceduresSelf-reported race/ethnicityRace-related differencesIndex admissionIndex hospitalizationCohort studyAsian patientsPrincipal diagnosisProcedural outcomesStenosis treatmentCare spectrumPatientsEthnic disparitiesStenosis
2023
Feasibility of Coronary Access Following Redo-TAVR for Evolut Failure: A Computed Tomography Simulation Study
Tang G, Spencer J, Rogers T, Grubb K, Gleason P, Gada H, Mahoney P, Dauerman H, Forrest J, Reardon M, Blanke P, Leipsic J, Abdel-Wahab M, Attizzani G, Puri R, Caskey M, Chung C, Chen Y, Dudek D, Allen K, Chhatriwalla A, Htun W, Blackman D, Tarantini G, Sanchez J, Schwartz G, Popma J, Sathananthan J. Feasibility of Coronary Access Following Redo-TAVR for Evolut Failure: A Computed Tomography Simulation Study. Circulation Cardiovascular Interventions 2023, 16: e013238. PMID: 37988439, PMCID: PMC10653288, DOI: 10.1161/circinterventions.123.013238.Peer-Reviewed Original ResearchConceptsRedo-TAVRSAPIEN 3Coronary accessRedo transcatheter aortic valve replacementYounger low-risk patientsFuture coronary accessSAPIEN 3 valveAortic valve replacementLow-risk patientsSelf-expanding valvesPre-TAVR CTValve replacementValve implantationCT planningEvolutImplant positionTomography imagingPatientsCTNodes 4Implant depthTAVRSubstudyNodes 5ValveImpact of New‐Onset Conduction Disturbances following Transcatheter Aortic Valve Replacement on Outcomes: A Single‐Center Study
See C, Wang Y, Huang H, Parise H, Yang Y, Tirziu D, Francese D, Papoutsidakis N, Bader E, Kaple R, Cleman M, Lansky A, Forrest J. Impact of New‐Onset Conduction Disturbances following Transcatheter Aortic Valve Replacement on Outcomes: A Single‐Center Study. Journal Of Interventional Cardiology 2023, 2023: 5390338. PMID: 37292113, PMCID: PMC10247319, DOI: 10.1155/2023/5390338.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementNew-onset conduction disturbancesAortic valve replacementPersistent conduction disturbancesConduction disturbancesValve replacementSurgical aortic valve replacementSingle-center retrospective analysisYale-New Haven HospitalSingle-center studyCause mortality ratesCause mortality riskLong-term outcomesNew Haven HospitalPeriprocedural factorsAortic stenosisConsecutive patientsTAVR proceduresTerm outcomesRetrospective analysisMortality riskMortality ratePatientsOutcomesPatient's ECGImpact of aortic valve replacement in symptomatic low-risk patients with less than severe aortic stenosis
Ito S, Laham R, Nkomo V, Forrest J, Reardon M, Little S, Mumtaz M, Gada H, Bajwa T, Langholz D, Heiser J, Chawla A, Jenson B, Attizanni G, Markowitz A, Huang J, Oh J. Impact of aortic valve replacement in symptomatic low-risk patients with less than severe aortic stenosis. Open Heart 2023, 10: e002297. PMID: 37173100, PMCID: PMC10186477, DOI: 10.1136/openhrt-2023-002297.Peer-Reviewed Original ResearchConceptsSevere aortic stenosisAortic valve replacementAortic stenosisSymptomatic patientsValve replacementKansas City Cardiomyopathy Questionnaire overall summary scoreEvolut Low Risk trialSurgical aortic valve replacementLow-risk trialsLow-risk patientsOverall summary scoreRate of deathQuality of lifeDisabling strokeEchocardiographic evidenceIsolated AVRHaemodynamic profileClinical outcomesHaemodynamic outcomesRisk trialsClinical trialsCalcium volumeSummary scoresPatientsCore laboratory measurementsCerebral Embolic Protection in Transcatheter Aortic Valve Replacement
Iskander M, Jamil Y, Forrest J, Madhavan M, Makkar R, Leon M, Lansky A, Ahmad Y. Cerebral Embolic Protection in Transcatheter Aortic Valve Replacement. Structural Heart 2023, 7: 100169. PMID: 37520138, PMCID: PMC10382985, DOI: 10.1016/j.shj.2023.100169.Peer-Reviewed Original ResearchTranscatheter aortic valve replacementCerebral embolic protection devicesCerebral embolic protectionAortic valve replacementEmbolic protection devicesValve replacementEmbolic protectionSymptomatic severe aortic stenosisSevere aortic stenosisLow-risk patientsPredictors of strokeOccurrence of complicationsRisk of strokeRecent trial dataRelevant clinical studiesOverall evidence baseExpansion of TAVRFeared complicationAortic stenosisSurgical riskTreatment optionsWorse outcomesClinical studiesPatientsTrial data
2022
Clinical Research on Transcatheter Aortic Valve Replacement for Bicuspid Aortic Valve Disease: Principles, Challenges, and an Agenda for the Future
Ahmad Y, Madhavan M, Baron S, Forrest J, Borger M, Leipsic J, Cavalcante J, Wang D, McCarthy P, Szerlip M, Kapadia S, Makkar R, Mack M, Leon M, Cohen D. Clinical Research on Transcatheter Aortic Valve Replacement for Bicuspid Aortic Valve Disease: Principles, Challenges, and an Agenda for the Future. Structural Heart 2022, 7: 100102. PMID: 37275317, PMCID: PMC10236801, DOI: 10.1016/j.shj.2022.100102.Peer-Reviewed Original ResearchTranscatheter aortic valve replacementBicuspid aortic valve diseaseSurgical aortic valve replacementAortic valve replacementAortic valve diseaseValve replacementClinical researchValve diseaseValvular heart diseaseDesign of RCTsProcedural therapiesProspective registryHeart diseaseExclusion criteriaRisk scorePatientsRCTsDiseaseCardiovascular communityMultidisciplinary workshopSelection biasTrialsInternational expertsPotential studiesRegistryImaging, Treatment Options, Patient Selection, and Outcome Considerations for Patients With Bicuspid Aortic Valve Disease
Ahmad Y, Agarwal V, Williams M, Wang D, Reardon M, Cavalcante J, Makkar R, Forrest J. Imaging, Treatment Options, Patient Selection, and Outcome Considerations for Patients With Bicuspid Aortic Valve Disease. Journal Of The Society For Cardiovascular Angiography & Interventions 2022, 1: 100506. PMID: 39132366, PMCID: PMC11307905, DOI: 10.1016/j.jscai.2022.100506.Peer-Reviewed Original ResearchAortic valve replacementTranscatheter aortic valve replacementBicuspid aortic valve diseaseAortic valve diseaseValve replacementValve diseaseBAV diseaseSevere symptomatic aortic stenosisSurgical aortic valve replacementPivotal randomized trialsAortic valve surgerySymptomatic aortic stenosisRandomized clinical trialsValve surgeryHeart teamAortic stenosisSurgical riskPatient selectionRandomized trialsBicuspid valveSurgical approachTreatment optionsClinical trialsPatientsDisease
2021
TCT-48 Incidence and Outcomes of Atrial Fibrillation in Patients Undergoing TAVR Versus SAVR: Experience From SURTAVI and Low-Risk Randomized Studies
Vora A, Gada H, Sherwood M, Lopes R, Forrest J, Huang J, Reardon M. TCT-48 Incidence and Outcomes of Atrial Fibrillation in Patients Undergoing TAVR Versus SAVR: Experience From SURTAVI and Low-Risk Randomized Studies. Journal Of The American College Of Cardiology 2021, 78: b19. DOI: 10.1016/j.jacc.2021.09.898.Peer-Reviewed Original ResearchCoronary Revascularization in Patients Undergoing Aortic Valve Replacement for Severe Aortic Stenosis
Patel KP, Michail M, Treibel TA, Rathod K, Jones DA, Ozkor M, Kennon S, Forrest JK, Mathur A, Mullen MJ, Lansky A, Baumbach A. Coronary Revascularization in Patients Undergoing Aortic Valve Replacement for Severe Aortic Stenosis. JACC Cardiovascular Interventions 2021, 14: 2083-2096. PMID: 34620388, DOI: 10.1016/j.jcin.2021.07.058.Peer-Reviewed Original ResearchConceptsAortic valve replacementCoronary artery diseaseAortic stenosisHemodynamic statusCoronary revascularizationValve replacementAssessment of CADPatients Undergoing Aortic Valve ReplacementConcomitant coronary artery diseaseImpact of ASSignificant coronary artery diseaseConcomitant aortic stenosisRole of revascularizationSevere aortic stenosisThird of patientsCohort of patientsDual pathologyArtery diseaseTherapeutic challengeCertain patientsMyocardial ischemiaCoronary assessmentPatientsRevascularizationMultidisciplinary teamRedo‐transcatheter aortic valve replacement with the supra‐annular, self‐expandable Evolut platform: Insights from the Transcatheter valve Therapy Registry
Attizzani GF, Dallan LAP, Forrest JK, Reardon MJ, Szeto WY, Liu F, Pelletier M. Redo‐transcatheter aortic valve replacement with the supra‐annular, self‐expandable Evolut platform: Insights from the Transcatheter valve Therapy Registry. Catheterization And Cardiovascular Interventions 2021, 99: 869-876. PMID: 34533891, DOI: 10.1002/ccd.29941.Peer-Reviewed Original ResearchConceptsTranscatheter Valve Therapy RegistryTranscatheter aortic valveRedo-TAVRTVT RegistryRedo transcatheter aortic valve replacementBetter short-term outcomesTotal aortic regurgitationAortic valve replacementLow-risk patientsShort-term outcomesHospital mortalityIndex hospitalizationAortic regurgitationValve replacementDevice successEvolut RSafety profileMyocardial infarctionAortic valveEvolut PROPatientsRegistryMean gradientOutcomesEvolutIMPACT OF SURGICAL AND TRANSCATHETER AORTIC VALVE REPLACEMENT IN SYMPTOMATIC PATIENTS OF LOW-GRADIENT AORTIC STENOSIS WITH DOPPLER VELOCITY INDEX GREATER THAN 0.25
Ito S, Laham R, Nkomo V, Forrest J, Reardon M, Little S, Landholz D, Oh J. IMPACT OF SURGICAL AND TRANSCATHETER AORTIC VALVE REPLACEMENT IN SYMPTOMATIC PATIENTS OF LOW-GRADIENT AORTIC STENOSIS WITH DOPPLER VELOCITY INDEX GREATER THAN 0.25. Journal Of The American College Of Cardiology 2021, 77: 1760. DOI: 10.1016/s0735-1097(21)03116-8.Peer-Reviewed Original ResearchOutcomes of Prosthesis-Patient Mismatch Following Supra-Annular Transcatheter Aortic Valve Replacement From the STS/ACC TVT Registry
Tang GHL, Sengupta A, Alexis SL, Bapat VN, Adams DH, Sharma SK, Kini AS, Kodali SK, Ramlawi B, Gada H, Vora AN, Forrest JK, Kaple RK, Liu F, Reardon MJ. Outcomes of Prosthesis-Patient Mismatch Following Supra-Annular Transcatheter Aortic Valve Replacement From the STS/ACC TVT Registry. JACC Cardiovascular Interventions 2021, 14: 964-976. PMID: 33958170, DOI: 10.1016/j.jcin.2021.03.040.Peer-Reviewed Original ResearchConceptsSevere prosthesis-patient mismatchTranscatheter aortic valve replacementProsthesis-patient mismatchDe novo stenosisAortic valve replacementTVT RegistryNovo stenosisValve replacementSTS/ACC TVT RegistryHigh residual gradientPre-procedural factorsLong-term outcomesAortic gradientAortic annulusClinical outcomesSurgical bioprosthesesAdverse outcomesClinical impactPatientsResidual gradientReadmissionRegistryMortalityLinear mixed modelsOutcomesRandomized Evaluation of TriGuard 3 Cerebral Embolic Protection After Transcatheter Aortic Valve Replacement REFLECT II
Nazif TM, Moses J, Sharma R, Dhoble A, Rovin J, Brown D, Horwitz P, Makkar R, Stoler R, Forrest J, Messé S, Dickerman S, Brennan J, Zivadinov R, Dwyer MG, Lansky AJ, Investigators R. Randomized Evaluation of TriGuard 3 Cerebral Embolic Protection After Transcatheter Aortic Valve Replacement REFLECT II. JACC Cardiovascular Interventions 2021, 14: 515-527. PMID: 33663779, DOI: 10.1016/j.jcin.2020.11.011.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementAortic valve replacementSafety endpointValve replacementProcedure-related ischemic strokeCerebral embolic protectionComposite efficacy endpointPrimary safety endpointCerebral embolizationCerebral protectionEfficacy endpointII trialCerebral injuryIschemic strokeEmbolic protectionPatientsDrug AdministrationUS sitesU.S. FoodEndpointData reviewTrialsMulticenterEmbolizationInjury
2020
MULTICENTER EVALUATION OF QUALITY OF LIFE IN PATIENTS WITH PARADOXICAL LOW-FLOW, LOW-GRADIENT UNDERGOING TRANSCATHETER AORTIC VALVE REPLACEMENT (PLO-FLOW TAVR STUDY)
Hirji S, Kaneko T, McGurk S, Cherkasky O, Ahmed H, Wong S, Salemi A, Kampaktsis P, Kaple R, Forrest J, Kini A, Malarczyk A, Kiehm S, Percy E, Harloff M, Yazdchi F, Shah P, Tang G. MULTICENTER EVALUATION OF QUALITY OF LIFE IN PATIENTS WITH PARADOXICAL LOW-FLOW, LOW-GRADIENT UNDERGOING TRANSCATHETER AORTIC VALVE REPLACEMENT (PLO-FLOW TAVR STUDY). Journal Of The American College Of Cardiology 2020, 75: 1488. DOI: 10.1016/s0735-1097(20)32115-x.Peer-Reviewed Original Research
2019
The initial U.S. experience with the Tempo active fixation temporary pacing lead in structural heart interventions
Nazif TM, Chen S, Codner P, Grossman PM, Menees DS, Sanchez CE, Yakubov SJ, White J, Kapadia S, Whisenant BK, Forrest JK, Krishnaswamy A, Arshi A, Orford JL, Leon MB, Dizon JM, Kodali SK, Chetcuti SJ. The initial U.S. experience with the Tempo active fixation temporary pacing lead in structural heart interventions. Catheterization And Cardiovascular Interventions 2019, 95: 1051-1056. PMID: 31478304, DOI: 10.1002/ccd.28476.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCardiac Pacing, ArtificialCardiac Surgical ProceduresEquipment DesignFemaleHeart RateHumansMalePacemaker, ArtificialPatient SafetyPerioperative CareRegistriesRetrospective StudiesRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeUnited StatesVentricular Function, RightConceptsTemporary cardiac pacingTemporary pacing leadStructural heart proceduresPacing leadsHeart proceduresCardiac pacingMulticenter retrospective studyMobilization of patientsRisk of perforationActive fixation mechanismStructural heart interventionsPericardial effusionRetrospective studyLead dislodgmentMean durationPace captureRight ventricleLead stabilitySignificant perforationPatientsHeart interventionsLead performancePacingCapture thresholdPerforation600.03 Self-Expanding Transcatheter Aortic Valve Replacement in Patients with Severe Aortic Stenosis and Bicuspid Morphology: A Report from the Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy RegistryTM
Forrest J, Ramlawi B, Popma J, Reardon M. 600.03 Self-Expanding Transcatheter Aortic Valve Replacement in Patients with Severe Aortic Stenosis and Bicuspid Morphology: A Report from the Society of Thoracic Surgeons/American College of Cardiology Transcatheter Valve Therapy RegistryTM. JACC Cardiovascular Interventions 2019, 12: s43. DOI: 10.1016/j.jcin.2019.01.155.Peer-Reviewed Original ResearchSelf-expanding transcatheter aortic valve replacementThoracic Surgeons/American CollegeTranscatheter aortic valve replacementAortic valve replacementSevere aortic stenosisTranscatheter valve therapiesValve replacementAortic stenosisValve therapyBicuspid morphologyAmerican CollegeStenosisPatientsTherapyCardiac Biomarkers in Transcatheter Aortic Valve Implantation
Hermany P, Forrest J. Cardiac Biomarkers in Transcatheter Aortic Valve Implantation. 2019, 147-164. DOI: 10.1007/978-3-030-05912-5_13.Peer-Reviewed Original ResearchAortic valve replacementValve replacementMyocardial injuryCardiac proceduresCardiac biomarkersTranscatheter aortic valve implantationTranscatheter aortic valve replacementAortic stenosis managementSevere aortic stenosisAortic valve implantationCardiac biomarker releaseStandard of careAppropriate clinical applicationValve implantationAortic stenosisSuch patientsHemodynamic alterationsAdverse outcomesBiomarker releaseCardiac conditionsTAVRNovel markerPatientsCardiac physiologyBiomarkersGender-Related Differences in Transcatheter Aortic Valve Implantation
Stair B, Forrest J. Gender-Related Differences in Transcatheter Aortic Valve Implantation. 2019, 189-200. DOI: 10.1007/978-3-030-05912-5_16.Peer-Reviewed Original ResearchSurgical aortic valve replacementTranscatheter aortic valve implantationAortic valve implantationValve implantationSevere symptomatic aortic stenosisSymptomatic aortic stenosisAortic valve replacementLow surgical riskChronic pressure overloadStandard of careCardiovascular disease statesGender-related differencesTAVR studiesValve replacementAortic stenosisSurgical riskAdverse outcomesPressure overloadRisk factorsTreatment outcomesFemale genderFemale heartsPatientsDisease statesImpact of gender
2018
Ventricular septal rupture complicating acute myocardial infarction: Incidence, treatment, and outcomes among medicare beneficiaries 1999–2014
Goldsweig AM, Wang Y, Forrest JK, Cleman MW, Minges KE, Mangi AA, Aronow HD, Krumholz HM, Curtis JP. Ventricular septal rupture complicating acute myocardial infarction: Incidence, treatment, and outcomes among medicare beneficiaries 1999–2014. Catheterization And Cardiovascular Interventions 2018, 92: 1104-1115. PMID: 29513365, DOI: 10.1002/ccd.27576.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionVentricular septal ruptureTimely primary PCIMortality ratePrimary PCIPercutaneous repairSeptal ruptureMyocardial infarctionRetrospective cohort studyUnadjusted mortality ratesUnrepaired patientsVSR repairFatal complicationCohort studyAnnual incidenceMedicare feeService beneficiariesPatientsIncidenceStudy periodMortalityHospitalizationInfarctionRepairPCIUTILIZATION OF DOBUTAMINE STRESS STUDIES IN PATIENTS WITH SYMPTOMATIC, SEVERE LOW-FLOW/LOW-GRADIENT AORTIC STENOSIS UNDERGOING TRANSCATHETER AORTIC VALVE REPLACEMENT
Chowdhury M, Trejo M, Lombo B, Forrest J, Lin B, Sugeng L. UTILIZATION OF DOBUTAMINE STRESS STUDIES IN PATIENTS WITH SYMPTOMATIC, SEVERE LOW-FLOW/LOW-GRADIENT AORTIC STENOSIS UNDERGOING TRANSCATHETER AORTIC VALVE REPLACEMENT. Journal Of The American College Of Cardiology 2018, 71: a1326. DOI: 10.1016/s0735-1097(18)31867-9.Peer-Reviewed Original Research