2017
Predictive Ability of Intermittent Daily Sickle Cell Pain Assessment: The PiSCES Project
Smith WR, McClish DK, Levenson J, Aisiku I, Dahman B, Bovbjerg VE, Roseff S, Roberts J. Predictive Ability of Intermittent Daily Sickle Cell Pain Assessment: The PiSCES Project. Pain Medicine 2017, 19: 1972-1981. PMID: 29036363, PMCID: PMC6176749, DOI: 10.1093/pm/pnx214.Peer-Reviewed Original ResearchConceptsSickle cell diseasePain daysPain assessmentPain measuresOne weekGold standardSickle Cell Epidemiology StudyMonths strategyDaily pain assessmentProspective cohort studyOne dayPiSCES projectCohort studySCD patientsMeasurement of R2Month assessmentCell diseasePainEpidemiology studiesDiary assessmentsDaily assessmentIntermittent assessmentCrisis daysWeeksMonthsComorbidity, Pain, Utilization, and Psychosocial Outcomes in Older versus Younger Sickle Cell Adults: The PiSCES Project
McClish DK, Smith WR, Levenson JL, Aisiku IP, Roberts JD, Roseff SD, Bovbjerg VE. Comorbidity, Pain, Utilization, and Psychosocial Outcomes in Older versus Younger Sickle Cell Adults: The PiSCES Project. BioMed Research International 2017, 2017: 4070547. PMID: 28459058, PMCID: PMC5387810, DOI: 10.1155/2017/4070547.Peer-Reviewed Original ResearchConceptsSickle Cell Epidemiology StudyHealth care utilizationPain daysPiSCES projectPain frequencyAmbulatory visitsPain intensityCare utilizationPainComorbiditiesEpidemiology studiesPsychosocial measuresAge groupsAdult groupPsychosocial outcomesPsychosocial variablesOlder adultsSomatic complaintsHealth careBehavioral coping strategiesTransition groupFurther studiesPatientsAdultsSCD
2015
Daily home opioid use in adults with sickle cell disease: The PiSCES project.
Smith WR, McClish DK, Dahman BA, Levenson JL, Aisiku IP, de A Citero V, Bovbjerg VE, Roberts JD, Penberthy LT, Roseff SD. Daily home opioid use in adults with sickle cell disease: The PiSCES project. Journal Of Opioid Management 2015, 11: 243-53. PMID: 25985809, DOI: 10.5055/jom.2015.0273.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAdaptation, PsychologicalAdolescentAdultAnalgesics, OpioidAnemia, Sickle CellAntisickling AgentsCost of IllnessDrug Administration ScheduleDrug Therapy, CombinationFemaleHumansHydroxyureaLongitudinal StudiesMaleMiddle AgedPainPain MeasurementQuality of LifeSelf AdministrationTime FactorsTreatment OutcomeYoung AdultConceptsSickle cell diseaseHome opioid useOpioid usePain daysOpioid usersMean painCell diseasePsychosocial variablesDaily pain diaryMajority of patientsNon-opioid analgesicsSomatic symptom burdenPiSCES projectOpioid prescribingPain frequencyCohort studySymptom burdenPain diaryPain intensityPatient characteristicsPhysical QoLOpioidsPatientsSCD samplesSimilar association
2009
Pain site frequency and location in sickle cell disease: The PiSCES project
McClish DK, Smith WR, Dahman BA, Levenson JL, Roberts JD, Penberthy LT, Aisiku IP, Roseff SD, Bovbjerg VE. Pain site frequency and location in sickle cell disease: The PiSCES project. Pain 2009, 145: 246-251. PMID: 19631468, PMCID: PMC2771372, DOI: 10.1016/j.pain.2009.06.029.Peer-Reviewed Original ResearchConceptsPain locationPain daysPain sitesBody chartSickle Cell Disease PainFrequency of painDaily pain diarySickle cell diseasePiSCES projectPain crisisDisease painED utilizationPain diaryFrequent painHealthcare utilizationEpidemiologic descriptionTreatment optionsLower extremitiesCell diseaseUpper backPainSCD managementUnplanned utilizationSixty subjectsUnderstanding of combinations
2008
Comparisons of High Versus Low Emergency Department Utilizers in Sickle Cell Disease
Aisiku IP, Smith WR, McClish DK, Levenson JL, Penberthy LT, Roseff SD, Bovbjerg VE, Roberts JD. Comparisons of High Versus Low Emergency Department Utilizers in Sickle Cell Disease. Annals Of Emergency Medicine 2008, 53: 587-593. PMID: 18926599, DOI: 10.1016/j.annemergmed.2008.07.050.Peer-Reviewed Original ResearchConceptsSickle cell disease patientsHigh ED utilizersSickle cell diseaseDisease patientsEmergency departmentCell diseaseQuality of lifeFrequency of painSickle cell painDescriptors of painBaseline dataLower hematocrit levelsHealth dataPain daysMore transfusionsPain characteristicsPain crisisED utilizationLaboratory variablesHigh utilizersMore painPainHematocrit levelsPatientsSummary scalesDaily assessment of pain in adults with sickle cell disease.
Smith WR, Penberthy LT, Bovbjerg VE, McClish DK, Roberts JD, Dahman B, Aisiku IP, Levenson JL, Roseff SD. Daily assessment of pain in adults with sickle cell disease. Annals Of Internal Medicine 2008, 148: 94-101. PMID: 18195334, DOI: 10.7326/0003-4819-148-2-200801150-00004.Peer-Reviewed Original ResearchConceptsSickle cell diseasePain daysSelf-reported painCell diseasePain intensityPatients age 16 yearsMean pain intensityProspective cohort studyUtilization daysHealth care utilizationDiary daysAge 16 yearsHealth care providersCohort studyMaximum painIndependent predictorsCare utilizationPainful episodesOpiate useAmbulatory careCare providersPainDaily assessmentPatientsDisease
2007
Depression and Anxiety in Adults With Sickle Cell Disease: The PiSCES Project
Levenson JL, McClish DK, Dahman BA, Bovbjerg VE, de A. Citero V, Penberthy LT, Aisiku IP, Roberts JD, Roseff SD, Smith WR. Depression and Anxiety in Adults With Sickle Cell Disease: The PiSCES Project. Psychosomatic Medicine 2007, 70: 192-196. PMID: 18158366, DOI: 10.1097/psy.0b013e31815ff5c5.Peer-Reviewed Original ResearchConceptsSickle cell diseaseSCD adultsCell diseaseDepressed subjectsSickle Cell Epidemiology StudyHigher mean painProspective cohort studyHealth-related qualitySF-36 subscalesPrevalence of depressionSickle cell crisisDomains of qualityMean painPain daysPiSCES projectOpioid usageOpioid utilizationCohort studyDaily painPain intensityHealthcare utilizationMore painBaseline variablesCell crisisHemoglobin types
2006
Gender Differences in Pain and Healthcare Utilization for Adult Sickle Cell Patients: The PiSCES Project
McClish DK, Levenson JL, Penberthy LT, Roseff SD, Bovbjerg VE, Roberts JD, Aisiku IP, Smith WR. Gender Differences in Pain and Healthcare Utilization for Adult Sickle Cell Patients: The PiSCES Project. Journal Of Women's Health 2006, 15: 146-154. PMID: 16536678, DOI: 10.1089/jwh.2006.15.146.Peer-Reviewed Original ResearchConceptsHealthcare utilizationAnalysis of covarianceAdult sickle cell patientsSickle cell disease (SCD) experienceSS genotypeEpisodes of painProspective cohort studyIntensity of painSickle cell crisisSickle cell patientsHigher pain ratingsStudy of PainPiSCES projectOpioid usagePain scoresAcute painCohort studyChronic painPain ratingsLower painCell crisisCell patientsPainPain experienceDisease experience
2005
Synergistic affective analgesic interaction between delta-9-tetrahydrocannabinol and morphine
Roberts JD, Gennings C, Shih M. Synergistic affective analgesic interaction between delta-9-tetrahydrocannabinol and morphine. European Journal Of Pharmacology 2005, 530: 54-58. PMID: 16375890, DOI: 10.1016/j.ejphar.2005.11.036.Peer-Reviewed Original ResearchConceptsExperimental pain modelsAnalgesic interactionPain modelVisual analog scaleFinding of synergyAffective responsesAffective componentsAffective aspectsAnalgesic effectAnalog scaleExperimental painNormal volunteersCrossover designMorphinePainSensory responsesPlaceboThermal stimuliSignificant interactionTHCSignificant effectFuture studiesSubjectsAnalgesiaAnalgesicsHealth related quality of life in sickle cell patients: The PiSCES project
McClish DK, Penberthy LT, Bovbjerg VE, Roberts JD, Aisiku IP, Levenson JL, Roseff SD, Smith WR. Health related quality of life in sickle cell patients: The PiSCES project. Health And Quality Of Life Outcomes 2005, 3: 50. PMID: 16129027, PMCID: PMC1253526, DOI: 10.1186/1477-7525-3-50.Peer-Reviewed Original ResearchConceptsQuality of lifeEmotional role functionBodily painMental healthRole functionPhysical functionGeneral healthCell diseaseSickle Cell Epidemiology StudySickle cell disease patientsBackgroundSickle cell diseaseHealth-related qualityMedical Outcomes StudySF-36 subscalesGeneral health subscaleSickle cell patientsChronic disease cohortsSickle cell diseaseCystic fibrosis patientsPiSCES projectAsthma patientsLower HRQoLPain levelsDialysis patientsHemodialysis patientsUnderstanding pain and improving management of sickle cell disease: the PiSCES study.
Smith WR, Bovbjerg VE, Penberthy LT, McClish DK, Levenson JL, Roberts JD, Gil K, Roseff SD, Aisiku IP. Understanding pain and improving management of sickle cell disease: the PiSCES study. Journal Of The National Medical Association 2005, 97: 183-93. PMID: 15712781, PMCID: PMC2568749.Peer-Reviewed Original ResearchConceptsSickle cell diseasePain episodesPain responseHealthcare utilizationCell diseaseSickle Cell Epidemiology StudyDaily pain diaryCare-seeking behaviorSCD painAnalgesic useOverall painAdult patientsFrequent hospitalizationsPain diaryOrgan failureSCD careChronic painTreatment advancesProlonged survivalRelated disabilityTimely carePainBiobehavioral interventionsAdult cohortEpidemiology studies
1988
Phase I clinical and pharmacokinetic study of trimetrexate using a daily x5 schedule.
Stewart JA, McCormack JJ, Tong W, Low JB, Roberts JD, Blow A, Whitfield LR, Haugh LD, Grove WR, Lopez AJ. Phase I clinical and pharmacokinetic study of trimetrexate using a daily x5 schedule. Cancer Research 1988, 48: 5029-35. PMID: 2970294.Peer-Reviewed Original ResearchConceptsWhite blood cellsM2/dGood performance status patientsMedian white blood cellPhase IDaily x5 schedulePhase II trialPharmacokinetic studyColon 26 tumorMurine i.Nonhematological toxicitiesPlatelet nadirsPrior therapyII trialStarting doseStatus patientsDose escalationTerminal eliminationDose administeredPlatelet toxicityDaily dosesSchedule dependencyPharmacokinetic analysisB16 melanomaDose levels