Age-associated changes in the frequency of naïve, memory and effector CD8+ T cells
Hong MS, Dan JM, Choi JY, Kang I. Age-associated changes in the frequency of naïve, memory and effector CD8+ T cells. Mechanisms Of Ageing And Development 2004, 125: 615-618. PMID: 15491679, DOI: 10.1016/j.mad.2004.07.001.Peer-Reviewed Original ResearchConceptsAge-associated changesT cell subsetsEffector CD8T cellsCell subsetsFrequencies of naïveFrequency of CD8Expression of CD45RAT cell functionEffector memoryPeripheral bloodCD8CM cellsDecreased frequencyCentral memoryFlow cytometryElderly peopleCell functionSimilar frequencyNaïveCellsCCR7CD45RABloodSubsetAge-Associated Change in the Frequency of Memory CD4+ T Cells Impairs Long Term CD4+ T Cell Responses to Influenza Vaccine
Kang I, Hong MS, Nolasco H, Park SH, Dan JM, Choi JY, Craft J. Age-Associated Change in the Frequency of Memory CD4+ T Cells Impairs Long Term CD4+ T Cell Responses to Influenza Vaccine. The Journal Of Immunology 2004, 173: 673-681. PMID: 15210831, DOI: 10.4049/jimmunol.173.1.673.Peer-Reviewed Original ResearchConceptsT cell responsesIL-7 levelsMemory CD4Long-term CD4T cellsCell responsesInfluenza vaccineIFN-gammaInfluenza virus-specific CD4Serum IL-7 levelsEM cellsLevels of CD4Virus-specific CD4Central memory CD4Effector memory CD4Cellular immune responsesFrequency of influenzaImportant clinical questionsAge-Associated ChangesEM CD4Influenza vaccinationTNF-alphaVaccination strategiesIL-7Immune response