1994
Regulation of the human IgE receptor (Fc epsilon RII/CD23) by EBV. Localization of an intron EBV-responsive enhancer and characterization of its cognate GC-box binding factors.
Lacy J, Roth G, Shieh B. Regulation of the human IgE receptor (Fc epsilon RII/CD23) by EBV. Localization of an intron EBV-responsive enhancer and characterization of its cognate GC-box binding factors. The Journal Of Immunology 1994, 153: 5537-48. PMID: 7989755, DOI: 10.4049/jimmunol.153.12.5537.Peer-Reviewed Original ResearchMeSH KeywordsBase SequenceCell LineCell Line, TransformedCell Transformation, ViralChloramphenicol O-AcetyltransferaseDNA-Binding ProteinsElectrophoresisEnhancer Elements, GeneticGene Expression RegulationGenes, ReporterHerpesvirus 4, HumanHumansIntronsMolecular Sequence DataPhosphorylationReceptors, IgETransfectionUltraviolet RaysEpstein-Barr viral nuclear antigen 1 antisense oligodeoxynucleotide inhibits proliferation of Epstein-Barr virus-immortalized B cells.
Roth G, Curiel T, Lacy J. Epstein-Barr viral nuclear antigen 1 antisense oligodeoxynucleotide inhibits proliferation of Epstein-Barr virus-immortalized B cells. Blood 1994, 84: 582-7. PMID: 8025284, DOI: 10.1182/blood.v84.2.582.bloodjournal842582.Peer-Reviewed Original ResearchConceptsEBNA-1EBNA-1 proteinAntisense oligodeoxynucleotidesEpstein-Barr virus-immortalized B cellsEpstein-Barr virus nuclear antigen 1EBV-negative cellsLatent viral proteinsNuclear antigen 1Potential therapeutic implicationsLymphoblastoid cellsEpisomal viral genomesUnmodified antisense oligodeoxynucleotidesNeoplastic diseaseTherapeutic implicationsB cellsInhibited proliferationEBVEffect of antisenseAntigen 1Antiproliferative effectsProtein expressionUntreated cellsImmortalized cellsViral proteinsProliferation
1990
Interleukin 6 is an autocrine growth factor for mesangial cells
Ruef C, Budde K, Lacy J, Northemann W, Baumann M, Sterzel R, Coleman D. Interleukin 6 is an autocrine growth factor for mesangial cells. Kidney International 1990, 38: 249-257. PMID: 2402117, DOI: 10.1038/ki.1990.193.Peer-Reviewed Original ResearchConceptsIL-6Autocrine growth factorInterleukin-6T cellsGrowth factorSecrete IL-6Possible paracrine roleAcute phase responseIL-6 mRNADose-dependent increaseIL-6 actsMesangial cell proliferationIL-6 resultsGlomerular inflammationNumber of MCsImmune responseRat MCsParacrine roleB cellsMesangial cellsMC-CMEndothelial cellsAutocrine signalsCell proliferationPlasmacytoma cells
1989
Rat mesangial cells produce granulocyte-macrophage colony-stimulating factor
Budde K, Coleman D, Lacy J, Sterzel R. Rat mesangial cells produce granulocyte-macrophage colony-stimulating factor. American Journal Of Physiology 1989, 257: f1065-f1078. PMID: 2690641, DOI: 10.1152/ajprenal.1989.257.6.f1065.Peer-Reviewed Original ResearchConceptsRat mesangial cellsGranulocyte-macrophage colony-stimulating factorCultured rat mesangial cellsMesangial cellsColony-stimulating factorGM-CSFMC-CMGlomerular mesangial cellsPeritoneal MPsEffector cellsIL-2Inflammatory processGlomerular diseaseInterleukin-2T cellsT lymphocytesInterleukin-4Murine GM-CSFRenal glomeruliSerum-free conditionsSoluble factorsProliferative activitySpecific cDNA probesGM-CSF mRNA transcriptsPresent findingsPost‐transcriptional mechanisms of deregulation of MYC following conversion of a human B cell line by Epstein‐Barr virus.
Lacy J, Summers W, Summers W. Post‐transcriptional mechanisms of deregulation of MYC following conversion of a human B cell line by Epstein‐Barr virus. The EMBO Journal 1989, 8: 1973-1980. PMID: 2551670, PMCID: PMC401064, DOI: 10.1002/j.1460-2075.1989.tb03603.x.Peer-Reviewed Original ResearchConceptsEpstein-Barr virusB cell linesBJAB cellsNegative Burkitt lymphoma linesPresence of EBVLymphoma linesBurkitt lymphoma linesCell linesNormal human B cellsHuman B cell linesHuman B cellsMYC mRNAEBV genomeVitro infectionMyc transcriptsB cellsEBVLymphoblastoid linesMYC expressionVirusMechanism of deregulationCellsPost-transcriptional mechanismsMYC
1987
Amplification and deregulation of MYC following Epstein-Barr virus infection of a human B-cell line.
Lacy J, Summers W, Watson M, Glazer P, Summers W. Amplification and deregulation of MYC following Epstein-Barr virus infection of a human B-cell line. Proceedings Of The National Academy Of Sciences Of The United States Of America 1987, 84: 5838-5842. PMID: 3039510, PMCID: PMC298958, DOI: 10.1073/pnas.84.16.5838.Peer-Reviewed Original ResearchConceptsBurkitt's lymphomaEBV infectionB cell linesEpstein-Barr virus infectionEBV-negative Burkitt lymphomasEBV-positive sublinesEpstein-Barr virusAmplification of MYCRole of EBVMYC expressionPositive Burkitt's lymphomaHuman B cell linesDeregulation of MYCVirus infectionVitro infectionInfectionEBVAltered expressionBJAB cellsMYC transcriptionVirusMYC oncogeneMYC locusMYCCells
1985
Effects of diacetyl diamines on in vitro activation and proliferation of human B lymphocytes.
Lacy J, Summers W, Canellakis Z. Effects of diacetyl diamines on in vitro activation and proliferation of human B lymphocytes. The Journal Of Immunology 1985, 135: 3772-6. PMID: 3877754, DOI: 10.4049/jimmunol.135.6.3772.Peer-Reviewed Original ResearchConceptsB cell activationHuman B lymphocytesB cellsHuman B cellsB lymphocytesCell activationGrowth factor-stimulated proliferationProliferation of PHAHuman B cell activationNormal B cellsHuman T cellsT cellsProliferative responseCowan IAntiproliferative effectsSpecific abrogationInhibitory effectLymphocytesActivationProliferationHexamethylenebisacetamideCellsDerivatives of polyaminesCulture mediumDose