2023
Complex Percutaneous Coronary Intervention Outcomes in Older Adults
Hanna J, Wang S, Kochar A, Park D, Damluji A, Henry G, Ahmad Y, Curtis J, Nanna M. Complex Percutaneous Coronary Intervention Outcomes in Older Adults. Journal Of The American Heart Association 2023, 12: e029057. PMID: 37776222, PMCID: PMC10727245, DOI: 10.1161/jaha.122.029057.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCoronary Artery DiseaseHemorrhageHumansMyocardial InfarctionMyocardial IschemiaPercutaneous Coronary InterventionTreatment OutcomeConceptsNoncomplex percutaneous coronary interventionsComplex percutaneous coronary interventionStable ischemic heart diseasePercutaneous coronary interventionIschemic heart diseaseTarget lesion revascularizationEvent-free survivalHeart diseaseOlder adultsCause deathLesion revascularizationClinical characteristicsElective percutaneous coronary interventionPercutaneous coronary intervention outcomesWorse event-free survivalMedical therapy useCox regression modelLarge health systemNoncardiac comorbiditiesRevascularization riskCoronary interventionTherapy useClinical outcomesDisease featuresLower riskContemporary Methods for Predicting Acute Kidney Injury After Coronary Intervention
Uzendu A, Kennedy K, Chertow G, Amin A, Giri J, Rymer J, Bangalore S, Lavin K, Anderson C, Wang T, Curtis J, Spertus J. Contemporary Methods for Predicting Acute Kidney Injury After Coronary Intervention. JACC Cardiovascular Interventions 2023, 16: 2294-2305. PMID: 37758384, PMCID: PMC10795198, DOI: 10.1016/j.jcin.2023.07.041.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAgedContrast MediaCreatinineFemaleHumansMalePercutaneous Coronary InterventionRisk AssessmentRisk FactorsTreatment OutcomeConceptsAcute kidney injuryPercutaneous coronary interventionValidation cohortKidney injuryCoronary interventionClinical careIncidence of AKIBedside risk scoreBaseline renal functionNCDR CathPCI RegistryLogistic regression modelsAKI riskNew dialysisAKI predictionCathPCI RegistryRenal functionCommon complicationDerivation cohortMedian ageAKI modelClinical instabilityPCI proceduresC-statisticPatient riskContrast dosesAssociation Between Claims‐Defined Frailty and Outcomes Following 30 Versus 12 Months of Dual Antiplatelet Therapy After Percutaneous Coronary Intervention: Findings From the EXTEND‐DAPT Study
Faridi K, Strom J, Kundi H, Butala N, Curtis J, Gao Q, Song Y, Zheng L, Tamez H, Shen C, Secemsky E, Yeh R. Association Between Claims‐Defined Frailty and Outcomes Following 30 Versus 12 Months of Dual Antiplatelet Therapy After Percutaneous Coronary Intervention: Findings From the EXTEND‐DAPT Study. Journal Of The American Heart Association 2023, 12: e029588. PMID: 37449567, PMCID: PMC10382113, DOI: 10.1161/jaha.123.029588.Peer-Reviewed Original ResearchMeSH KeywordsAgedAspirinChild, PreschoolDrug Therapy, CombinationFrailtyHemorrhageHumansMedicarePercutaneous Coronary InterventionPlatelet Aggregation InhibitorsTreatment OutcomeUnited StatesConceptsExtended duration dual antiplatelet therapyDuration dual antiplatelet therapyNet adverse clinical eventsDual antiplatelet therapyAdverse clinical eventsPercutaneous coronary interventionCoronary interventionClinical eventsNonfrail patientsAntiplatelet therapyFrail patientsClaims dataMonths of DAPTClaims-based indexYears of ageMajor bleedingCause mortalityMultivariable adjustmentOlder patientsDAPT studyResults PatientsBackground FrailtyMyocardial infarctionClinical trialsMedicare claims
2022
Hospital Characteristics and Early Enrollment Trends in the American College of Cardiology Voluntary Public Reporting Program
Castro-Dominguez YS, Curtis JP, Masoudi FA, Wang Y, Messenger JC, Desai NR, Slattery LE, Dehmer GJ, Minges KE. Hospital Characteristics and Early Enrollment Trends in the American College of Cardiology Voluntary Public Reporting Program. JAMA Network Open 2022, 5: e2147903. PMID: 35142829, PMCID: PMC8832180, DOI: 10.1001/jamanetworkopen.2021.47903.Peer-Reviewed Original ResearchMeSH KeywordsCardiac CatheterizationCardiologyCross-Sectional StudiesDefibrillators, ImplantableFemaleForecastingHospitalsHumansMalePercutaneous Coronary InterventionResearch DesignUnited StatesConceptsPublic reporting programsHospital characteristicsCharacteristics of hospitalsEligible hospitalsAmerican CollegeNational Cardiovascular Data Registry CathPCIReporting ProgramHospital rankingsHospital 1 monthCross-sectional studyQuality of careStepwise logistic regressionOdds of participationCoronary interventionDischarge medicationsHospital factorsICD RegistryLarge hospital systemNonparticipating hospitalsProcedural volumeMAIN OUTCOMEHospitalLogistic regressionProcedure dataHospital system
2021
Comparison of Patients Undergoing Percutaneous Coronary Intervention in Contemporary U.S. Practice With ISCHEMIA Trial Population
Chatterjee S, Fanaroff AC, Parzynski C, Curtis J, Kolansky DM, Maddox TM, Mukherjee D, Yeh RW, Giri J. Comparison of Patients Undergoing Percutaneous Coronary Intervention in Contemporary U.S. Practice With ISCHEMIA Trial Population. JACC Cardiovascular Interventions 2021, 14: 2344-2349. PMID: 34736733, DOI: 10.1016/j.jcin.2021.08.047.Peer-Reviewed Original ResearchMeSH KeywordsCross-Sectional StudiesHumansIschemiaMyocardial IschemiaPercutaneous Coronary InterventionTreatment OutcomeConceptsStable ischemic heart diseasePercutaneous coronary interventionISCHEMIA trialSIHD patientsCoronary interventionNational Cardiovascular Data Registry CathPCI RegistryStudy periodHospital mortality rateHigh-risk featuresProportion of patientsTrial inclusion criteriaComparison of patientsIschemic heart diseaseCross-sectional analysisIschemic burdenMedian hospitalAngina symptomsCathPCI RegistryTrial populationComparator groupEnrollment criteriaMyocardial infarctionHeart diseaseU.S. patientsInclusion criteriaThe bleeding risk treatment paradox at the physician and hospital level: Implications for reducing bleeding in patients undergoing percutaneous coronary intervention
Amin AP, Frogge N, Kulkarni H, Ridolfi G, Ewald G, Miller R, Hall B, Rogers S, Gluckman T, Curtis J, Masoudi FA, Rao SV. The bleeding risk treatment paradox at the physician and hospital level: Implications for reducing bleeding in patients undergoing percutaneous coronary intervention. American Heart Journal 2021, 243: 221-231. PMID: 34543645, DOI: 10.1016/j.ahj.2021.08.021.Peer-Reviewed Original ResearchMeSH KeywordsHemorrhageHospitalsHumansPercutaneous Coronary InterventionPhysiciansRegistriesRisk FactorsTreatment OutcomeConceptsRisk-treatment paradoxPercutaneous coronary interventionVascular closure deviceCoronary interventionClosure deviceBAS useNational Cardiovascular Data Registry CathPCINational Cardiovascular Data Registry CathPCI RegistryPost-PCI bleedingHigh-risk tertileHigher bleeding rateInter-physician variationLevel of physiciansPCI patientsCathPCI RegistryIndependent predictorsTransradial interventionRisk tertilesCostly complicationBleeding rateHigh prevalenceHigh riskMortality riskBleedingLower riskComparative Outcomes of Percutaneous Coronary Intervention for ST-Segment–Elevation Myocardial Infarction Among Medicare Beneficiaries With Multivessel Coronary Artery Disease
Secemsky EA, Butala N, Raja A, Khera R, Wang Y, Curtis JP, Maddox TM, Virani SS, Armstrong EJ, Shunk KA, Brindis RG, Bhatt D, Yeh RW. Comparative Outcomes of Percutaneous Coronary Intervention for ST-Segment–Elevation Myocardial Infarction Among Medicare Beneficiaries With Multivessel Coronary Artery Disease. Circulation Cardiovascular Interventions 2021, 14: e010323. PMID: 34372676, PMCID: PMC8485756, DOI: 10.1161/circinterventions.120.010323.Peer-Reviewed Original ResearchMeSH KeywordsAgedCoronary Artery DiseaseHumansMedicarePercutaneous Coronary InterventionRegistriesST Elevation Myocardial InfarctionTime FactorsTreatment OutcomeUnited StatesComparing Baseline Data From Registries With Trials Evidence From the CathPCI Registry and DAPT Study
Butala NM, Faridi KF, Secemsky EA, Song Y, Curtis J, Gibson CM, Brindis R, Shen C, Yeh RW. Comparing Baseline Data From Registries With Trials Evidence From the CathPCI Registry and DAPT Study. JACC Cardiovascular Interventions 2021, 14: 1386-1388. PMID: 34167685, PMCID: PMC8800637, DOI: 10.1016/j.jcin.2021.03.065.Peer-Reviewed Original ResearchMeSH KeywordsDrug Therapy, CombinationHumansPercutaneous Coronary InterventionPlatelet Aggregation InhibitorsRegistriesTreatment OutcomePredicting In-Hospital Mortality in Patients Undergoing Percutaneous Coronary Intervention
Castro-Dominguez YS, Wang Y, Minges KE, McNamara RL, Spertus JA, Dehmer GJ, Messenger JC, Lavin K, Anderson C, Blankinship K, Mercado N, Clary JM, Osborne AD, Curtis JP, Cavender MA. Predicting In-Hospital Mortality in Patients Undergoing Percutaneous Coronary Intervention. Journal Of The American College Of Cardiology 2021, 78: 216-229. PMID: 33957239, DOI: 10.1016/j.jacc.2021.04.067.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionHospital mortalityQuality improvement effortsCoronary interventionDevelopment cohortValidation cohortRisk-standardized mortality ratesHospital risk-standardized mortality ratesBedside risk scoreHigh-risk patientsIn-Hospital MortalityHospital mortality riskRisk of mortalityLevel of consciousnessProcedural urgencyCathPCI RegistryClinical presentationRisk cohortRisk stratificationCardiovascular instabilityCardiac arrestMortality riskRisk scoreClinical acuityClinical relevanceTemporal Changes and Institutional Variation in Use of Percutaneous Coronary Intervention for ST-Elevation Myocardial Infarction With Multivessel Coronary Artery Disease in the United States
Secemsky EA, Butala N, Raja A, Khera R, Wang Y, Curtis JP, Maddox TM, Virani SS, Armstrong EJ, Shunk KA, Brindis RG, Bhatt D, Yeh RW. Temporal Changes and Institutional Variation in Use of Percutaneous Coronary Intervention for ST-Elevation Myocardial Infarction With Multivessel Coronary Artery Disease in the United States. JAMA Cardiology 2021, 6: 574-580. PMID: 33146666, PMCID: PMC7643043, DOI: 10.1001/jamacardio.2020.5354.Peer-Reviewed Original ResearchMeSH KeywordsAgedCoronary StenosisDrug-Eluting StentsFemaleHumansMaleMiddle AgedPercutaneous Coronary InterventionPractice Patterns, Physicians'RegistriesST Elevation Myocardial InfarctionUnited StatesConceptsMV-percutaneous coronary interventionST-elevation myocardial infarctionMultivessel percutaneous coronary interventionPercutaneous coronary interventionMajor epicardial vesselsPCI useMV diseaseCoronary interventionIndex procedureMyocardial infarctionSTEMI admissionsEpicardial vesselsNational Cardiovascular Data Registry CathPCI RegistryIndex percutaneous coronary interventionMore major epicardial vesselsMultivessel coronary artery diseaseCoronary stentsSmall randomized studiesDays of dischargeCoronary artery diseaseMinority of patientsIndex admissionNonculprit lesionsCathPCI RegistryComplete revascularizationPrognosis of Claims‐ Versus Trial‐Based Ischemic and Bleeding Events Beyond 1 Year After Coronary Stenting
Butala NM, Faridi KF, Secemsky EA, Song Y, Curtis J, Gibson CM, Kazi D, Shen C, Yeh RW. Prognosis of Claims‐ Versus Trial‐Based Ischemic and Bleeding Events Beyond 1 Year After Coronary Stenting. Journal Of The American Heart Association 2021, 10: e018744. PMID: 33682431, PMCID: PMC8174225, DOI: 10.1161/jaha.120.018744.Peer-Reviewed Original ResearchConceptsUnadjusted mortality ratesIschemic eventsDAPT studyMortality rateEnd pointCox proportional hazards modelPercutaneous coronary interventionProportional hazards modelCardiovascular clinical trialsTrial adjudicationBleeding eventsCathPCI RegistryCoronary interventionCoronary stentingSimilar prognosisPrognostic significanceClinical eventsClinical trialsMedicare claimsAdministrative claimsMortality riskHazards modelPatientsPrognosisDeathUse of Mechanical Circulatory Support Devices Among Patients With Acute Myocardial Infarction Complicated by Cardiogenic Shock
Dhruva SS, Ross JS, Mortazavi BJ, Hurley NC, Krumholz HM, Curtis JP, Berkowitz AP, Masoudi FA, Messenger JC, Parzynski CS, Ngufor CG, Girotra S, Amin AP, Shah ND, Desai NR. Use of Mechanical Circulatory Support Devices Among Patients With Acute Myocardial Infarction Complicated by Cardiogenic Shock. JAMA Network Open 2021, 4: e2037748. PMID: 33616664, PMCID: PMC7900859, DOI: 10.1001/jamanetworkopen.2020.37748.Peer-Reviewed Original ResearchMeSH KeywordsAgedAssisted CirculationCross-Sectional StudiesExtracorporeal Membrane OxygenationFemaleHeart ArrestHeart-Assist DevicesHospitals, High-VolumeHospitals, Low-VolumeHospitals, TeachingHumansIntra-Aortic Balloon PumpingMaleMiddle AgedMyocardial InfarctionPercutaneous Coronary InterventionRisk FactorsShock, CardiogenicConceptsMicroaxial left ventricular assist deviceIntra-aortic balloon pumpLeft ventricular assist devicePercutaneous coronary interventionAcute myocardial infarctionMechanical circulatory support devicesCardiogenic shockHospital-level variationSignificant hospital-level variationCirculatory support devicesMCS devicesUse of IABPDevice useMedian proportionAcute Myocardial Infarction ComplicatedCardiology-National Cardiovascular Data RegistryChest Pain-MI RegistryLimited clinical trial evidenceNational Cardiovascular Data RegistryMyocardial Infarction ComplicatedFirst medical contactSupport devicesClinical trial evidenceExtracorporeal membrane oxygenationCoronary artery stenosisComparability of Event Adjudication Versus Administrative Billing Claims for Outcome Ascertainment in the DAPT Study
Faridi KF, Tamez H, Butala NM, Song Y, Shen C, Secemsky EA, Mauri L, Curtis JP, Strom JB, Yeh RW. Comparability of Event Adjudication Versus Administrative Billing Claims for Outcome Ascertainment in the DAPT Study. Circulation Cardiovascular Quality And Outcomes 2021, 14: e006589. PMID: 33435731, PMCID: PMC7855905, DOI: 10.1161/circoutcomes.120.006589.Peer-Reviewed Original ResearchMeSH KeywordsAgedDrug Therapy, CombinationFemaleHumansMaleMedicareMyocardial InfarctionPercutaneous Coronary InterventionPlatelet Aggregation InhibitorsStrokeTreatment OutcomeUnited StatesConceptsNegative predictive valuePositive predictive valueMyocardial infarctionPredictive valueDAPT studyClinical trialsAdjudicated eventsClaims dataNational Cardiovascular Data Registry CathPCI RegistryClinical events committeeTrial of patientsPercutaneous coronary interventionTrial end pointsKappa statisticsAdjudicated deathCathPCI RegistryCerebrovascular eventsCoronary interventionCumulative incidenceEvents committeeOutcome ascertainmentBilling claimsInpatient hospitalizationBleeding rateCardiovascular disease
2020
Revascularization Practices and Outcomes in Patients With Multivessel Coronary Artery Disease Who Presented With Acute Myocardial Infarction and Cardiogenic Shock in the US, 2009-2018
Khera R, Secemsky EA, Wang Y, Desai NR, Krumholz HM, Maddox TM, Shunk KA, Virani SS, Bhatt DL, Curtis J, Yeh RW. Revascularization Practices and Outcomes in Patients With Multivessel Coronary Artery Disease Who Presented With Acute Myocardial Infarction and Cardiogenic Shock in the US, 2009-2018. JAMA Internal Medicine 2020, 180: 1317-1327. PMID: 32833024, PMCID: PMC9377424, DOI: 10.1001/jamainternmed.2020.3276.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedCohort StudiesCoronary VesselsFemaleFollow-Up StudiesHospital MortalityHumansMaleMiddle AgedMyocardial InfarctionPatient DischargePercutaneous Coronary InterventionRisk AssessmentRisk FactorsShock, CardiogenicST Elevation Myocardial InfarctionTime FactorsTreatment OutcomeUnited StatesConceptsST-segment elevation myocardial infarctionMultivessel percutaneous coronary interventionMultivessel coronary artery diseasePercutaneous coronary interventionAcute myocardial infarctionCoronary artery diseaseCulprit vessel percutaneous coronary interventionCardiogenic shockHospital mortalityArtery diseaseMyocardial infarctionCohort studyPrimary outcomeHospital variationPCI strategyMedicare beneficiariesUnderwent multivessel PCISignificant hospital variationElevation myocardial infarctionSubset of patientsHigh-risk populationRecent evidenceHospital complicationsPCI useRevascularization practiceResponse by Amin et al to Letters Regarding Article, “The Evolving Landscape of Impella Use in the United States Among Patients Undergoing Percutaneous Coronary Intervention With Mechanical Circulatory Support”
Amin AP, Rao SV, Bach RG, Curtis JP, Desai N, McNeely C, Al-Badarin F, House JA, Kulkarni H, Masoudi FA, Spertus JA. Response by Amin et al to Letters Regarding Article, “The Evolving Landscape of Impella Use in the United States Among Patients Undergoing Percutaneous Coronary Intervention With Mechanical Circulatory Support”. Circulation 2020, 142: e82-e84. PMID: 32776840, DOI: 10.1161/circulationaha.120.048260.Peer-Reviewed Original ResearchDuration of P2Y12 inhibitor Prescription After Percutaneous Coronary Intervention in Patients on Oral Anticoagulants (from NCDR CathPCI Registry)
Saad M, Tobolski J, Kolte D, Wang Y, Minges K, Hira RS, Curtis JP, Abbott JD. Duration of P2Y12 inhibitor Prescription After Percutaneous Coronary Intervention in Patients on Oral Anticoagulants (from NCDR CathPCI Registry). The American Journal Of Cardiology 2020, 133: 182-184. PMID: 32819682, DOI: 10.1016/j.amjcard.2020.07.029.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, OralAgedAnticoagulantsCoronary Artery DiseaseDrug Administration ScheduleFemaleHumansMaleMiddle AgedPercutaneous Coronary InterventionPractice Patterns, Physicians'Purinergic P2Y Receptor AntagonistsUse of Administrative Claims Data to Estimate Treatment Effects for 30 Versus 12 Months of Dual Antiplatelet Therapy After Percutaneous Coronary Intervention
Faridi KF, Tamez H, Strom JB, Song Y, Butala NM, Shen C, Secemsky EA, Mauri L, Curtis JP, Gibson CM, Yeh RW. Use of Administrative Claims Data to Estimate Treatment Effects for 30 Versus 12 Months of Dual Antiplatelet Therapy After Percutaneous Coronary Intervention. Circulation 2020, 142: 306-308. PMID: 32687440, PMCID: PMC7374757, DOI: 10.1161/circulationaha.120.047729.Peer-Reviewed Original ResearchMeSH KeywordsClinical Trials as TopicDual Anti-Platelet TherapyHumansMedicarePercutaneous Coronary InterventionPlatelet Aggregation InhibitorsThrombosisUnited StatesContemporary Trends, Predictors and Outcomes of Perforation During Percutaneous Coronary Intervention (From the NCDR Cath PCI Registry)
Nairooz R, Parzynski CS, Curtis JP, Mohsen A, McNulty E, Uretsky BF, Hakeem A. Contemporary Trends, Predictors and Outcomes of Perforation During Percutaneous Coronary Intervention (From the NCDR Cath PCI Registry). The American Journal Of Cardiology 2020, 130: 37-45. PMID: 32665131, DOI: 10.1016/j.amjcard.2020.06.014.Peer-Reviewed Original ResearchMeSH KeywordsAgedCoronary OcclusionCoronary VesselsCross-Sectional StudiesFemaleHumansIntraoperative ComplicationsMaleMiddle AgedPercutaneous Coronary InterventionRegistriesRisk AssessmentConceptsPercutaneous coronary interventionCoronary artery perforationAdverse eventsCardiogenic shockStudy periodCoronary interventionChronic total occlusion (CTO) PCISaphenous vein graft percutaneous coronary interventionProportion of PCIsVein graft percutaneous coronary interventionNational Cardiovascular Data Registry CathPCI RegistryGraft percutaneous coronary interventionLargest real-world experienceCTO percutaneous coronary interventionComplex percutaneous coronary interventionMultivariable logistic regression modelNon-CP patientsOutcome of perforationTotal PCI volumeUse of atherectomyType C lesionsCoronary artery bypassHigh rateLife-threatening complicationsConcomitant significant increaseSex Differences in 1‐Year Health Status Following Percutaneous Coronary Intervention in Patients Without Acute Myocardial Infarction: Results From the China PEACE Prospective Study
Zheng X, Dreyer RP, Curtis JP, Liu S, Xu X, Bai X, Li X, Zhang H, Wang S, Masoudi FA, Spertus JA, Li J, Krumholz HM, Group F. Sex Differences in 1‐Year Health Status Following Percutaneous Coronary Intervention in Patients Without Acute Myocardial Infarction: Results From the China PEACE Prospective Study. Journal Of The American Heart Association 2020, 9: e014421. PMID: 32131687, PMCID: PMC7335522, DOI: 10.1161/jaha.119.014421.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionAcute myocardial infarctionSAQ Summary ScoreCoronary interventionHealth status outcomesMyocardial infarctionHealth statusSummary scoresSAQ qualityAngina frequencyStatus outcomesPercutaneous coronary intervention studiesSAQ angina frequency scoreAngina frequency scoreCoronary Intervention StudyMarginal clinical significanceSAQ angina frequencyCardiac risk factorsChinese tertiary hospitalBackground Sex differencesSex differencesMultivariable adjustmentDiabetes mellitusTertiary hospitalLife scoresAssociation of Use of an Intravascular Microaxial Left Ventricular Assist Device vs Intra-aortic Balloon Pump With In-Hospital Mortality and Major Bleeding Among Patients With Acute Myocardial Infarction Complicated by Cardiogenic Shock
Dhruva SS, Ross JS, Mortazavi BJ, Hurley NC, Krumholz HM, Curtis JP, Berkowitz A, Masoudi FA, Messenger JC, Parzynski CS, Ngufor C, Girotra S, Amin AP, Shah ND, Desai NR. Association of Use of an Intravascular Microaxial Left Ventricular Assist Device vs Intra-aortic Balloon Pump With In-Hospital Mortality and Major Bleeding Among Patients With Acute Myocardial Infarction Complicated by Cardiogenic Shock. JAMA 2020, 323: 734-745. PMID: 32040163, PMCID: PMC7042879, DOI: 10.1001/jama.2020.0254.Peer-Reviewed Original ResearchMeSH KeywordsAgedCause of DeathExtracorporeal Membrane OxygenationFemaleHeart ArrestHeart-Assist DevicesHemorrhageHospital MortalityHumansIntra-Aortic Balloon PumpingMaleMatched-Pair AnalysisMiddle AgedMyocardial InfarctionPercutaneous Coronary InterventionPropensity ScoreRegistriesRetrospective StudiesShock, CardiogenicST Elevation Myocardial InfarctionConceptsMicroaxial left ventricular assist deviceIntra-aortic balloon pumpLeft ventricular assist deviceAcute myocardial infarctionPercutaneous coronary interventionNational Cardiovascular Data RegistryCardiogenic shockHemodynamic supportMyocardial infarctionRegistry-based retrospective cohort studyCardiology-National Cardiovascular Data RegistryChest Pain-MI RegistryST-elevation myocardial infarctionMechanical circulatory support devicesGreater hemodynamic supportHospital major bleedingRetrospective cohort studyPropensity-matched pairsCirculatory support devicesVentricular assist deviceClinical laboratory dataHospital mortalityMajor bleedingHospital deathCohort study