2014
Primary Prevention Implantable Cardioverter-Defibrillators and Survival in Older Women
Zeitler EP, Hellkamp AS, Fonarow GC, Hammill SC, Curtis LH, Hernandez AF, Al-Khalidi HR, Curtis JP, Heidenreich PA, Anstrom KJ, Peterson ED, Mark DB, Hammill BG, Sanders GD, Al-Khatib SM. Primary Prevention Implantable Cardioverter-Defibrillators and Survival in Older Women. JACC Heart Failure 2014, 3: 159-167. PMID: 25543969, PMCID: PMC4461749, DOI: 10.1016/j.jchf.2014.09.006.Peer-Reviewed Original ResearchConceptsPrimary prevention implantable cardioverter defibrillatorsImplantable cardioverter defibrillatorHeart failureCardioverter defibrillatorOlder womenNational Cardiovascular Data Registry ICD RegistryLeft ventricular dysfunctionSignificant survival benefitSurvival of womenYears of ageMedicare claims databaseEligible patientsCause mortalityPrimary endpointVentricular dysfunctionSurvival benefitICD RegistryClaims databaseHeart failure databaseLonger survivalClinical trialsPropensity score methodsPatientsWomenSurvival
2013
Survival of Patients Receiving a Primary Prevention Implantable Cardioverter-Defibrillator in Clinical Practice vs Clinical Trials
Al-Khatib SM, Hellkamp A, Bardy GH, Hammill S, Hall WJ, Mark DB, Anstrom KJ, Curtis J, Al-Khalidi H, Curtis LH, Heidenreich P, Peterson ED, Sanders G, Clapp-Channing N, Lee KL, Moss AJ. Survival of Patients Receiving a Primary Prevention Implantable Cardioverter-Defibrillator in Clinical Practice vs Clinical Trials. JAMA 2013, 309: 55-62. PMID: 23280225, PMCID: PMC3638257, DOI: 10.1001/jama.2012.157182.Peer-Reviewed Original ResearchConceptsPrimary prevention ICDsPrimary prevention clinical trialsTrial-eligible patientsSurvival of patientsPrevention clinical trialsClinical trialsICD RegistrySCD-HeFTClinical practiceRegistry patientsMADIT-IISimilar patientsNational Cardiovascular Data Registry ICD RegistryPrimary prevention implantable cardioverter defibrillatorsSurvival rateImplantable cardioverter-defibrillator therapyMADIT II criteriaMADIT II patientsSCD-HeFT criteriaCardioverter-defibrillator therapyClinical trial patientsLarge national registryRandomized clinical trialsProportional hazards modelImplantable cardioverter defibrillator