2021
Use and Outcomes of Dual Chamber or Cardiac Resynchronization Therapy Defibrillators Among Older Patients Requiring Ventricular Pacing in the National Cardiovascular Data Registry Implantable Cardioverter Defibrillator Registry
Borne RT, Masoudi FA, Curtis JP, Zipse MM, Sandhu A, Hsu JC, Peterson PN. Use and Outcomes of Dual Chamber or Cardiac Resynchronization Therapy Defibrillators Among Older Patients Requiring Ventricular Pacing in the National Cardiovascular Data Registry Implantable Cardioverter Defibrillator Registry. JAMA Network Open 2021, 4: e2035470. PMID: 33496796, PMCID: PMC7838925, DOI: 10.1001/jamanetworkopen.2020.35470.Peer-Reviewed Original ResearchConceptsCardiac resynchronization therapyHeart failure hospitalizationClass I indicationsUse of CRTFailure hospitalizationMedian odds ratioCohort studyOlder patientsVentricular pacingImplant ratesNational Cardiovascular Data Registry Implantable Cardioverter Defibrillator RegistryNational Cardiovascular Data Registry ICD RegistryReduced left ventricular ejection fractionMultivariable Cox proportional hazards modelsFrequent right ventricular pacingImplantable Cardioverter-Defibrillator RegistryPrior heart failure hospitalizationLeft ventricular ejection fractionImplantable cardioverter defibrillator implantationThird-degree atrioventricular blockCardiac resynchronization therapy defibrillatorCox proportional hazards modelBradycardia pacing indicationFirst-time implantationFrequent RV pacing
2020
Mortality and readmission in non-ischemic compared with ischemic cardiomyopathies after implantable cardioverter-defibrillator implantation
Freeman J, Bjerre J, Parzynski C, Minges K, Ahmad T, Desai N, Enriquez A, Spatz E, Friedman D, Curtis J, Hlatky M, Higgins A. Mortality and readmission in non-ischemic compared with ischemic cardiomyopathies after implantable cardioverter-defibrillator implantation. European Heart Journal 2020, 41: ehaa946.0788. DOI: 10.1093/ehjci/ehaa946.0788.Peer-Reviewed Original ResearchNon-ischemic cardiomyopathyImplantable cardioverter defibrillator implantationPrimary prevention ICDsCardioverter-defibrillator implantationIschemic cardiomyopathyICM patientsNational Cardiovascular Data Registry ICD RegistryCox proportional hazards regression modelPrimary prevention ICD implantationLeft ventricular ejection fractionProportional hazards regression modelsOne-year mortalityHeart failure readmissionVentricular ejection fractionKaplan-Meier curvesHazards regression modelsRisk of mortalityMedian followCause readmissionICD implantationEjection fractionHeart failureHospital readmissionICD RegistryPatient subgroupsComparison of Mortality and Readmission in Non-Ischemic Versus Ischemic Cardiomyopathy After Implantable Cardioverter-Defibrillator Implantation
Higgins AY, Bjerre J, Parzynski CS, Minges KE, Ahmad T, Desai NR, Enriquez A, Spatz ES, Friedman DJ, Curtis JP, Hlatky MA, Freeman JV. Comparison of Mortality and Readmission in Non-Ischemic Versus Ischemic Cardiomyopathy After Implantable Cardioverter-Defibrillator Implantation. The American Journal Of Cardiology 2020, 133: 116-125. PMID: 32862971, DOI: 10.1016/j.amjcard.2020.07.035.Peer-Reviewed Original ResearchConceptsNon-ischemic cardiomyopathyImplantable cardioverter defibrillator implantationCardioverter-defibrillator implantationICM patientsIschemic cardiomyopathyNational Cardiovascular Data Registry ICD RegistryCox proportional hazards regression modelPrimary prevention ICD implantationLeft ventricular ejection fractionProportional hazards regression modelsPrimary prevention ICDsRetrospective cohort studyVentricular ejection fractionKaplan-Meier curvesHazards regression modelsRisk of mortalityComparison of mortalityMedian followCohort studyICD implantationEjection fractionHeart failureHospital readmissionICD RegistryPatient subgroupsPeriprocedural Risk and Survival Associated With Implantable Cardioverter-Defibrillator Placement in Older Patients With Advanced Heart Failure
Fudim M, Ali-Ahmed F, Parzynski CS, Ambrosy AP, Friedman DJ, Pokorney SD, Curtis JP, Fonarow GC, Masoudi FA, Hernandez AF, Al-Khatib SM. Periprocedural Risk and Survival Associated With Implantable Cardioverter-Defibrillator Placement in Older Patients With Advanced Heart Failure. JAMA Cardiology 2020, 5: 643-651. PMID: 32211811, PMCID: PMC7097837, DOI: 10.1001/jamacardio.2020.0391.Peer-Reviewed Original ResearchConceptsAdvanced heart failureAdvanced HF populationHeart transplant listingPeriprocedural complication rateHeart failureSudden cardiac deathComparator groupVentricular assist deviceInotrope useTransplant listingCardiac deathComplication rateHF populationPrimary preventionCardiac arrestNew York Heart Association class IV symptomsNational Cardiovascular Data Registry ICD RegistryAssist deviceLeft ventricular ejection fractionImplantable cardioverter-defibrillator placementAdvanced HF groupClass IV symptomsFirst-time ICDLeft ventricular assist deviceNYHA class II
2015
Does Age Influence Cardiac Resynchronization Therapy Use and Outcome?
Heidenreich PA, Tsai V, Bao H, Curtis J, Goldstein M, Curtis L, Hernandez A, Peterson P, Turakhia MP, Masoudi FA. Does Age Influence Cardiac Resynchronization Therapy Use and Outcome? JACC Heart Failure 2015, 3: 497-504. PMID: 25982109, DOI: 10.1016/j.jchf.2015.01.012.Peer-Reviewed Original ResearchConceptsLeft ventricular ejection fractionICD implantationOlder patientsTrial criteriaNew York Heart Association functional class IIIAge groupsSocial Security Death IndexPatients age 85Receipt of CRTFunctional class IIICardiac resynchronization therapyVentricular ejection fractionClinical trial criteriaDifferent age groupsPatient ageEjection fractionICD RegistryImproved survivalPrimary outcomeResynchronization therapyTherapy useDeath IndexMean ageClinical trialsRegistry dataCardiac Resynchronization Therapy in Women Versus Men
Zusterzeel R, Spatz ES, Curtis JP, Sanders WE, Selzman KA, Piña IL, Bao H, Ponirakis A, Varosy PD, Masoudi FA, Caños DA, Strauss DG. Cardiac Resynchronization Therapy in Women Versus Men. Circulation Cardiovascular Quality And Outcomes 2015, 8: s4-s11. PMID: 25714821, DOI: 10.1161/circoutcomes.114.001548.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overBundle-Branch BlockCardiac Resynchronization TherapyCardiac Resynchronization Therapy DevicesDefibrillators, ImplantableElectric CountershockFemaleHealth Status DisparitiesHeart Conduction SystemHeart FailureHumansKaplan-Meier EstimateMalePropensity ScoreProportional Hazards ModelsRegistriesRisk FactorsSex FactorsStroke VolumeTreatment OutcomeUnited StatesVentricular Function, LeftConceptsLeft bundle branch blockQRS durationImplantable cardioverter defibrillatorPatient sexDeath riskCardioverter defibrillatorBetter survivalMortality differencesNew York Heart Association class IIILeft ventricular ejection fractionWomen Versus MenCardiac resynchronization therapyVentricular ejection fractionRelative death riskBenefit of CRTLonger QRS durationShorter QRS durationBundle branch blockLower mortality riskEjection fractionHeart failureResynchronization therapyCardiac resynchronizationBranch blockMortality risk
2014
Clinical Effectiveness of Cardiac Resynchronization Therapy Versus Medical Therapy Alone Among Patients With Heart Failure
Khazanie P, Hammill BG, Qualls LG, Fonarow GC, Hammill SC, Heidenreich PA, Al-Khatib SM, Piccini JP, Masoudi FA, Peterson PN, Curtis JP, Hernandez AF, Curtis LH. Clinical Effectiveness of Cardiac Resynchronization Therapy Versus Medical Therapy Alone Among Patients With Heart Failure. Circulation Heart Failure 2014, 7: 926-934. PMID: 25227768, PMCID: PMC4244212, DOI: 10.1161/circheartfailure.113.000838.Peer-Reviewed Original ResearchConceptsAcute Decompensated Heart Failure National RegistryImplantable Cardioverter-Defibrillator RegistryHeart failureMedical therapyCardiovascular readmissionCause readmissionQRS durationNational Cardiovascular Data Registry Implantable Cardioverter Defibrillator RegistryLeft ventricular ejection fractionCox proportional hazards modelHistorical control cohortOptimal medical therapyCardiac resynchronization therapyVentricular ejection fractionProportional hazards modelMultivariable adjustmentEjection fractionICD RegistryResynchronization therapyClinical effectivenessControl cohortNational registryClinical trialsLower riskHazards modelTemporal Trends in Patient Characteristics and Outcomes Among Medicare Beneficiaries Undergoing Primary Prevention Implantable Cardioverter-Defibrillator Placement in the United States, 2006–2010
Borne RT, Peterson PN, Greenlee R, Heidenreich PA, Wang Y, Curtis JP, Tzou WS, Varosy PD, Kremers MS, Masoudi FA. Temporal Trends in Patient Characteristics and Outcomes Among Medicare Beneficiaries Undergoing Primary Prevention Implantable Cardioverter-Defibrillator Placement in the United States, 2006–2010. Circulation 2014, 130: 845-853. PMID: 25095884, DOI: 10.1161/circulationaha.114.008653.Peer-Reviewed Original ResearchConceptsPrimary prevention ICD implantationDevice-related complicationsPatient characteristicsICD implantationICD RegistryNational Cardiovascular Data Registry ICD RegistryPrimary prevention implantable cardioverter-defibrillator placementConcomitant cardiac resynchronization therapyLeft ventricular ejection fractionImplantable cardioverter-defibrillator placementMultivariable hierarchical logistic regressionCardiac resynchronization therapy devicesCardiac resynchronization therapyVentricular ejection fractionResynchronization therapy devicesCommunity practice settingsSingle-lead deviceHierarchical logistic regressionClinical characteristicsOlder patientsEjection fractionResynchronization therapyPrimary preventionPatient populationHospital characteristicsComparative effectiveness of cardiac resynchronization therapy with an implantable cardioverter-defibrillator versus defibrillator therapy alone: a cohort study.
Masoudi FA, Mi X, Curtis LH, Peterson PN, Curtis JP, Fonarow GC, Hammill SC, Heidenreich PA, Al-Khatib SM, Piccini JP, Qualls LG, Hernandez AF. Comparative effectiveness of cardiac resynchronization therapy with an implantable cardioverter-defibrillator versus defibrillator therapy alone: a cohort study. Annals Of Internal Medicine 2014, 160: 603-11. PMID: 24798523, DOI: 10.7326/m13-1879.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCardiac Resynchronization TherapyComparative Effectiveness ResearchDefibrillators, ImplantableElectrocardiographyHeart FailureHumansInfectionsPatient ReadmissionPropensity ScoreRetrospective StudiesRisk FactorsStroke VolumeTreatment OutcomeVentricular Dysfunction, LeftConceptsReduced left ventricular ejection fractionLeft ventricular ejection fractionHeart failure readmissionVentricular ejection fractionCardiac resynchronization therapyICD therapyQRS durationLower riskCohort studyICD RegistryResynchronization therapyEjection fractionNational Cardiovascular Data Registry ICD RegistryImplantable cardioverter-defibrillator therapyLeft bundle branch blockPropensity-matched patientsRetrospective cohort studyCardioverter-defibrillator therapyDevice-related complicationsBundle branch blockDevice-related infectionsCardiovascular readmissionCause readmissionDefibrillator therapyICD implantation
2013
Cardiac Perforation From Implantable Cardioverter-Defibrillator Lead Placement
Hsu JC, Varosy PD, Bao H, Dewland TA, Curtis JP, Marcus GM. Cardiac Perforation From Implantable Cardioverter-Defibrillator Lead Placement. Circulation Cardiovascular Quality And Outcomes 2013, 6: 582-590. PMID: 24002030, DOI: 10.1161/circoutcomes.113.000299.Peer-Reviewed Original ResearchConceptsPredictors of perforationCardiac perforationICD recipientsMajor complicationsGreater oddsImplantable cardioverter defibrillator lead placementHigher left ventricular ejection fractionFirst-time ICD recipientsLeft ventricular ejection fractionHierarchical multivariable logistic regressionHeart failure classICD lead implantationAssociated adverse eventsVentricular ejection fractionMultivariable logistic regressionLength of stayBundle branch blockCardiac bypass surgeryHospital mortalityHospital deathHospital stayBypass surgeryFeared complicationMultivariable adjustmentAdverse eventsPatient, Physician, and Procedural Factors Influencing the Use of Defibrillation Testing during Initial Implantable Cardioverter Defibrillator Insertion: Findings from the NCDR®
RUSSO AM, WANG Y, AL‐KHATIB S, CURTIS JP, LAMPERT R. Patient, Physician, and Procedural Factors Influencing the Use of Defibrillation Testing during Initial Implantable Cardioverter Defibrillator Insertion: Findings from the NCDR®. Pacing And Clinical Electrophysiology 2013, 36: 1522-1531. PMID: 23981009, DOI: 10.1111/pace.12248.Peer-Reviewed Original ResearchConceptsHospital adverse eventsDFT testingAdverse eventsImplantable cardioverter-defibrillator insertionLeft ventricular ejection fractionCardiac resynchronization therapy devicesPrimary prevention indicationVentricular ejection fractionResynchronization therapy devicesProspective randomized dataImplantable cardioverter defibrillator (ICD) technologyDefibrillation threshold testingPatterns of practiceMore comorbiditiesPrevention indicationDefibrillator insertionEjection fractionHeart failureAtrial arrhythmiasDefibrillation testingIndependent associationProcedural characteristicsTeaching hospitalDefibrillator technologyImplant procedure
2012
Electrophysiology Studies in Patients Undergoing ICD Implantation: Findings from the NCDR®
CHENG A, WANG Y, BERGER RD, CALKINS H, BUXTON AE, CURTIS JP, LAMPERT R. Electrophysiology Studies in Patients Undergoing ICD Implantation: Findings from the NCDR®. Pacing And Clinical Electrophysiology 2012, 35: 912-918. PMID: 22670627, DOI: 10.1111/j.1540-8159.2012.03441.x.Peer-Reviewed Original ResearchConceptsICD implantationElectrophysiology studyEjection fractionSudden deathDe novo ICD implantationSecondary prevention ICD recipientsSudden death risk stratificationLeft ventricular ejection fractionImplantable cardioverter defibrillator implantationNarrow QRS intervalPrimary prevention ICDsDeath risk stratificationCardioverter-defibrillator implantationCongestive heart failureVentricular ejection fractionHigher ejection fractionHistory of syncopeMonomorphic ventricular tachycardiaLogistic regression analysisFuture ICD therapyHierarchical logistic regression analysisICD therapyClinical characteristicsComplication rateDefibrillator implantation
2007
Preventing tomorrow's sudden cardiac death today Part I: Current data on risk stratification for sudden cardiac death
Al-Khatib SM, Sanders GD, Bigger JT, Buxton AE, Califf RM, Carlson M, Curtis A, Curtis J, Fain E, Gersh BJ, Gold MR, Haghighi-Mood A, Hammill SC, Healey J, Hlatky M, Hohnloser S, Kim RJ, Lee K, Mark D, Mianulli M, Mitchell B, Prystowsky EN, Smith J, Steinhaus D, Zareba W, conference F. Preventing tomorrow's sudden cardiac death today Part I: Current data on risk stratification for sudden cardiac death. American Heart Journal 2007, 153: 941-950. PMID: 17540194, DOI: 10.1016/j.ahj.2007.03.003.Peer-Reviewed Original ResearchConceptsSudden cardiac deathRisk stratificationCardiac deathHeart diseasePrevention of SCDLeft ventricular ejection fractionDuke Clinical Research InstituteOvert heart diseaseVentricular ejection fractionStructural heart diseaseHeart Rhythm SocietyClinical Research InstituteImplantable cardioverter defibrillatorCurrent dataEjection fractionSuch patientsSCD eventsCardioverter defibrillatorUS FoodDrug AdministrationPredictive valuePatientsDuke CenterClinical cardiologyEffective prevention
2003
The association of left ventricular ejection fraction, mortality, and cause of death in stable outpatients with heart failure
Curtis JP, Sokol SI, Wang Y, Rathore SS, Ko DT, Jadbabaie F, Portnay EL, Marshalko SJ, Radford MJ, Krumholz HM. The association of left ventricular ejection fraction, mortality, and cause of death in stable outpatients with heart failure. Journal Of The American College Of Cardiology 2003, 42: 736-742. PMID: 12932612, DOI: 10.1016/s0735-1097(03)00789-7.Peer-Reviewed Original ResearchConceptsLeft ventricular ejection fractionVentricular ejection fractionHeart failureCause of deathLVEF groupHF patientsMultivariable adjustmentEjection fractionStable outpatientsAssociation of LVEFHigher left ventricular ejection fractionLow left ventricular ejection fractionDigitalis Investigation Group trialHigh LVEF groupStable HF patientsPrognostic importanceAbsolute riskPrognostic indicatorSinus rhythmGroup trialsMortality ratePatientsMortalityDeathOutpatientsThe association of left ventricular ejection fraction, mortality, and cause of death in stable patients with heart failure
Curtis J, Sokol S, Wang Y, Rathore S, Ko D, Jadbabaie F, Portnay E, Marshalko S, Radford M, Krumholz H. The association of left ventricular ejection fraction, mortality, and cause of death in stable patients with heart failure. Journal Of The American College Of Cardiology 2003, 41: 219-220. DOI: 10.1016/s0735-1097(03)81606-6.Peer-Reviewed Original ResearchLeft ventricular ejection fractionVentricular ejection fractionCause of deathStable patientsEjection fractionHeart failurePatientsMortalityAssociation of Serum Digoxin Concentration and Outcomes in Patients With Heart Failure
Rathore SS, Curtis JP, Wang Y, Bristow MR, Krumholz HM. Association of Serum Digoxin Concentration and Outcomes in Patients With Heart Failure. JAMA 2003, 289: 871-878. PMID: 12588271, DOI: 10.1001/jama.289.7.871.Peer-Reviewed Original ResearchConceptsSerum digoxin concentrationHigh serum digoxin concentrationsLeft ventricular ejection fractionVentricular ejection fractionHeart failureMortality rateDIG trialDigoxin therapyEjection fractionDigoxin concentrationsDepressed left ventricular systolic functionDigitalis Investigation Group trialHigher absolute mortality rateLeft ventricular systolic functionOverall mortality benefitVentricular systolic functionCause mortality ratesAbsolute mortality ratesLower mortality rateCause mortalityMultivariable adjustmentMortality benefitSystolic functionClinical outcomesSerum concentrations