2022
Device-Sizing and Associated Complications With Left Atrial Appendage Occlusion: Findings From the NCDR LAAO Registry
Sandhu A, Varosy P, Du C, Aleong R, Tumolo A, West J, Tzou W, Curtis J, Freeman J, Friedman D, Hess P. Device-Sizing and Associated Complications With Left Atrial Appendage Occlusion: Findings From the NCDR LAAO Registry. Circulation Cardiovascular Interventions 2022, 15: e012183. PMID: 36472194, DOI: 10.1161/circinterventions.122.012183.Peer-Reviewed Original ResearchConceptsAtrial appendage occlusionAppendage occlusionPericardial effusionLower oddsOversized deviceComposite adverse outcomeNonvalvular atrial fibrillationShort-term complicationsShort-term outcomesSignificant leakDevice embolismSelect patientsAdverse eventsWatchman deviceAssociated complicationsPeridevice leakAtrial fibrillationAdverse outcomesDevice embolizationHigh prevalenceDevice migrationManufacturer's recommendationsPatientsStudy periodUndersized devicesAntithrombotic Therapy After Left Atrial Appendage Occlusion in Patients With Atrial Fibrillation
Freeman JV, Higgins AY, Wang Y, Du C, Friedman DJ, Daimee UA, Minges KE, Pereira L, Goldsweig AM, Price MJ, Reddy VY, Gibson D, Doshi SK, Varosy PD, Masoudi FA, Curtis JP. Antithrombotic Therapy After Left Atrial Appendage Occlusion in Patients With Atrial Fibrillation. Journal Of The American College Of Cardiology 2022, 79: 1785-1798. PMID: 35512858, PMCID: PMC9097170, DOI: 10.1016/j.jacc.2022.02.047.Peer-Reviewed Original ResearchConceptsLeft atrial appendage occlusionAdverse eventsPivotal trialsWatchman deviceTreatment protocolAntithrombotic strategiesAppendage occlusionLower riskFrailty regressionPercutaneous left atrial appendage occlusionNational Cardiovascular Data RegistryContemporary U.S. practiceDual antiplatelet therapyAtrial appendage occlusionConcomitant aspirinPostprocedure careAdjusted riskAntiplatelet therapyAntithrombotic medicationAntithrombotic therapyAtrial fibrillationAdverse outcomesTrial protocolAntithrombotic agentsMedication strategies
2019
The Evolving Landscape of Impella® Use in the United States Among Patients Undergoing Percutaneous Coronary Intervention with Mechanical Circulatory Support
Amin AP, Spertus JA, Curtis JP, Desai N, Masoudi FA, Bach RG, McNeely C, Al-Badarin F, House JA, Kulkarni H, Rao SV. The Evolving Landscape of Impella® Use in the United States Among Patients Undergoing Percutaneous Coronary Intervention with Mechanical Circulatory Support. Circulation 2019, 141: 273-284. PMID: 31735078, DOI: 10.1161/circulationaha.119.044007.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionMechanical circulatory supportAcute kidney injuryImpella useOdds ratioKidney injuryCoronary interventionClinical outcomesCirculatory supportAdverse outcomesPremier Healthcare DatabaseClustering of patientsHigh rateAdverse eventsPatient levelImpellaPropensity adjustmentHospital levelHealthcare databasesPatientsUS hospitalsHospitalPropensity scoreAssociated outcomesWide variationAssociation of Physician Specialty With Long-Term Implantable Cardioverter-Defibrillator Complication and Reoperations Rates
Chui PW, Wang Y, Ranasinghe I, Mitiku TY, Seto AH, Rosman L, Lampert R, Minges KE, Enriquez AD, Curtis JP. Association of Physician Specialty With Long-Term Implantable Cardioverter-Defibrillator Complication and Reoperations Rates. Circulation Cardiovascular Quality And Outcomes 2019, 12: e005374. PMID: 31185734, PMCID: PMC7412734, DOI: 10.1161/circoutcomes.118.005374.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overClinical CompetenceDefibrillators, ImplantableElectric CountershockFee-for-Service PlansFemaleHumansIncidenceMaleMedicarePostoperative ComplicationsPractice Patterns, Physicians'RegistriesReoperationRisk AssessmentRisk FactorsSpecializationTime FactorsTreatment OutcomeUnited StatesConceptsLong-term device-related complicationsDevice-related complicationsICD implantationLong-term outcomesPhysician specialtyGeneral cardiologistsThoracic surgeonsHigh riskNational Cardiovascular Data Registry ICD RegistryLong-term adverse outcomesImplantable cardioverter defibrillator implantationPhysician specialty trainingCardioverter-defibrillator implantationCumulative incidence rateCase-mix adjusted ratesReoperation rateBackground PatientsConclusions PatientsICD RegistryPrimary outcomeAdverse outcomesIncidence rateInterventional cardiologistsAdjusted ratesReoperation
2018
Outcomes following implantable cardioverter-defibrillator generator replacement in patients with recovered left ventricular systolic function: The National Cardiovascular Data Registry
Thomas IC, Wang Y, See VY, Minges KE, Curtis JP, Hsu JC. Outcomes following implantable cardioverter-defibrillator generator replacement in patients with recovered left ventricular systolic function: The National Cardiovascular Data Registry. Heart Rhythm 2018, 16: 733-740. PMID: 30414460, DOI: 10.1016/j.hrthm.2018.11.005.Peer-Reviewed Original ResearchConceptsLV ejection fractionNational Cardiovascular Data Registry ICD RegistryReduced LV ejection fractionICD generator replacementLeft ventricular systolic functionVentricular systolic functionHF readmissionSystolic functionGenerator replacementAdverse outcomesImplantable Cardioverter-Defibrillator Generator ReplacementNational Cardiovascular Data RegistryLV systolic functionEjection fractionICD RegistryPeriprocedural eventsPrognostic associationAmerican CollegeHigh riskData registryLower riskMedicare beneficiariesPatientsReadmissionClinical encounters
2017
Modeling Major Adverse Outcomes of Pediatric and Adult Patients With Congenital Heart Disease Undergoing Cardiac Catheterization
Jayaram N, Spertus JA, Kennedy KF, Vincent R, Martin GR, Curtis JP, Nykanen D, Moore PM, Bergersen L. Modeling Major Adverse Outcomes of Pediatric and Adult Patients With Congenital Heart Disease Undergoing Cardiac Catheterization. Circulation 2017, 136: 2009-2019. PMID: 28882885, PMCID: PMC5698125, DOI: 10.1161/circulationaha.117.027714.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsBlood CoagulationBlood Coagulation DisordersCardiac CatheterizationChildChild, PreschoolChi-Square DistributionFemaleHeart Defects, CongenitalHemodynamicsHumansInfantInfant, NewbornKidneyLogistic ModelsMaleMultivariate AnalysisOdds RatioRegistriesRenal InsufficiencyReproducibility of ResultsRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeUnited StatesYoung AdultConceptsProcedure-type risk categoriesMajor adverse outcomesMajor adverse eventsCardiac catheterizationCongenital heart diseaseAdverse eventsValidation cohortAdverse outcomesCongenital cardiac catheterizationIMPACT RegistryRisk categoriesHemodynamic vulnerabilityHeart diseaseMultivariable hierarchical logistic regression modelsFinal risk-adjustment modelSingle ventricle physiologyRisk-adjusted outcomesHierarchical logistic regression modelsRisk-adjustment modelsLogistic regression modelsRisk standardizationRenal insufficiencyAdult patientsConsecutive patientsPatient characteristics
2015
Association of Physician Certification in Interventional Cardiology With In-Hospital Outcomes of Percutaneous Coronary Intervention
Fiorilli PN, Minges KE, Herrin J, Messenger JC, Ting HH, Nallamothu BK, Lipner RS, Hess BJ, Holmboe ES, Brennan JJ, Curtis JP. Association of Physician Certification in Interventional Cardiology With In-Hospital Outcomes of Percutaneous Coronary Intervention. Circulation 2015, 132: 1816-1824. PMID: 26384518, PMCID: PMC4641797, DOI: 10.1161/circulationaha.115.017523.Peer-Reviewed Original ResearchConceptsEmergency coronary artery bypassPercutaneous coronary interventionCoronary artery bypassArtery bypassVascular complicationsHospital mortalityEnd pointHospital outcomesCoronary interventionPCI proceduresIn-Hospital OutcomesPrimary end pointSecondary end pointsComposite end pointRisk of bleedingHierarchical multivariable modelInternal Medicine certificationAmerican BoardCathPCI RegistryPatient characteristicsPCI volumeUnadjusted outcomesAdverse outcomesPatient outcomesMultivariable modelUse of Remote Monitoring Is Associated With Lower Risk of Adverse Outcomes Among Patients With Implanted Cardiac Defibrillators
Akar JG, Bao H, Jones PW, Wang Y, Varosy PD, Masoudi FA, Stein KM, Saxon LA, Normand SL, Curtis JP. Use of Remote Monitoring Is Associated With Lower Risk of Adverse Outcomes Among Patients With Implanted Cardiac Defibrillators. Circulation Arrhythmia And Electrophysiology 2015, 8: 1173-1180. PMID: 26092577, DOI: 10.1161/circep.114.003030.Peer-Reviewed Original ResearchConceptsImplantable cardioverter defibrillatorInitial implantable cardioverter defibrillatorCause mortalityLower riskAdverse outcomesNational Cardiovascular Data Registry ICD RegistryRemote patient monitoringSocial Security Death Master FileCause rehospitalization rateRisk of rehospitalizationImplanted cardiac defibrillatorsDeath Master FileCardiomyopathy pathogenesisCause rehospitalizationICD RegistryRehospitalization ratesMultivariable analysisStudy cohortVital statusService patientsCardioverter defibrillatorCox modelMedicare populationMedicare feePatients
2014
Procedure timing as a predictor of inhospital adverse outcomes from implantable cardioverter-defibrillator implantation: Insights from the National Cardiovascular Data Registry
Hsu JC, Varosy PD, Parzynski CS, Chaudhry SI, Dewland TA, Curtis JP, Marcus GM. Procedure timing as a predictor of inhospital adverse outcomes from implantable cardioverter-defibrillator implantation: Insights from the National Cardiovascular Data Registry. American Heart Journal 2014, 169: 45-52.e3. PMID: 25497247, DOI: 10.1016/j.ahj.2014.10.006.Peer-Reviewed Original ResearchConceptsHospital stayAdverse eventsICD recipientsWeekends/holidaysInhospital deathGreater oddsNational Cardiovascular Data Registry ICD RegistryFirst-time ICD recipientsImplantable cardioverter defibrillator implantationNational Cardiovascular Data RegistryImplantable cardioverter-defibrillator (ICD) proceduresImplantable cardioverter defibrillator recipientsHierarchical multivariable logistic regressionInhospital adverse outcomesCardioverter-defibrillator implantationProlonged hospital stayMultivariable logistic regressionReal-world populationAfternoon/eveningTotal complicationsMultivariable adjustmentAdverse outcomesHospital characteristicsICD implantsData registry
2013
Developing a Risk Model for In-Hospital Adverse Events Following Implantable Cardioverter-Defibrillator Implantation A Report From the NCDR (National Cardiovascular Data Registry)
Dodson JA, Reynolds MR, Bao H, Al-Khatib SM, Peterson ED, Kremers MS, Mirro MJ, Curtis JP, NCDR. Developing a Risk Model for In-Hospital Adverse Events Following Implantable Cardioverter-Defibrillator Implantation A Report From the NCDR (National Cardiovascular Data Registry). Journal Of The American College Of Cardiology 2013, 63: 788-796. PMID: 24333491, PMCID: PMC3954985, DOI: 10.1016/j.jacc.2013.09.079.Peer-Reviewed Original ResearchConceptsHospital adverse eventsAdverse eventsComplication rateValidation cohortRisk scoreIn-Hospital Adverse EventsImplantable cardioverter defibrillator implantationICD implantation procedureOutcomes of patientsCardioverter-defibrillator implantationHigh-risk subgroupsMultivariable logistic regressionHospital complicationsPeriprocedural complicationsICD implantationICD placementAdverse outcomesRisk subgroupsProcedural volumeStudy groupPatientsProlong lifeCase mixA ReportImplantation procedure
2010
The Relation Between Hospital Procedure Volume and Complications of Cardioverter-Defibrillator Implantation From the Implantable Cardioverter-Defibrillator Registry
Freeman JV, Wang Y, Curtis JP, Heidenreich PA, Hlatky MA. The Relation Between Hospital Procedure Volume and Complications of Cardioverter-Defibrillator Implantation From the Implantable Cardioverter-Defibrillator Registry. Journal Of The American College Of Cardiology 2010, 56: 1133-1139. PMID: 20863954, DOI: 10.1016/j.jacc.2010.07.007.Peer-Reviewed Original ResearchConceptsAdverse eventsProcedure volumeImplantable Cardioverter-Defibrillator RegistryHospital adverse outcomesInitial ICD implantationCardioverter-defibrillator implantationHigh-volume hospitalsLow-volume hospitalsPatients' clinical characteristicsBetter clinical outcomesHospital procedure volumeVolume-outcome relationshipNCDR ICD RegistryClinical characteristicsICD implantationICD RegistryProcedural complicationsClinical outcomesAdverse outcomesHospital characteristicsBiventricular ICDsImplant volumeHospitalRepresentative populationICD
2005
Anemia and Outcomes in Patients With Heart Failure: A Study From the National Heart Care Project
Kosiborod M, Curtis JP, Wang Y, Smith GL, Masoudi FA, Foody JM, Havranek EP, Krumholz HM. Anemia and Outcomes in Patients With Heart Failure: A Study From the National Heart Care Project. JAMA Internal Medicine 2005, 165: 2237-2244. PMID: 16246989, DOI: 10.1001/archinte.165.19.2237.Peer-Reviewed Original ResearchConceptsHeart failureLower hematocrit levelsIndependent predictorsHematocrit levelsComorbid illnessesHigh riskCare ProjectMultivariable logistic regression analysisPatients 65 yearsPrincipal discharge diagnosisAcute care hospitalsLogistic regression analysisLow hematocrit valuesCause mortalityHF patientsMultiple comorbiditiesMultivariable adjustmentOlder patientsCare hospitalClinical factorsHospital readmissionComorbid conditionsDischarge diagnosisSevere anemiaAdverse outcomesThe Obesity Paradox: Body Mass Index and Outcomes in Patients With Heart Failure
Curtis JP, Selter JG, Wang Y, Rathore SS, Jovin IS, Jadbabaie F, Kosiborod M, Portnay EL, Sokol SI, Bader F, Krumholz HM. The Obesity Paradox: Body Mass Index and Outcomes in Patients With Heart Failure. JAMA Internal Medicine 2005, 165: 55-61. PMID: 15642875, DOI: 10.1001/archinte.165.1.55.Peer-Reviewed Original ResearchConceptsBody mass indexHeart failureDigitalis Investigation Group trialBaseline body mass indexStable heart failureStudy of patientsLean patientsObese patientsMass indexHealthy weightAdverse outcomesChronic diseasesGroup trialsGeneral populationStable outpatientsBetter outcomesPatientsOutcomesOverweightObesityOutpatientsDiseaseTrials