2019
Whole Genome Sequencing to Characterize Monogenic and Polygenic Contributions in Patients Hospitalized with Early-Onset Myocardial Infarction
Khera AV, Chaffin M, Zekavat S, Collins RL, Roselli C, Natarajan P, Lichtman JH, D'Onofrio G, Mattera J, Dreyer R, Spertus JA, Taylor KD, Psaty BM, Rich SS, Post W, Gupta N, Gabriel S, Lander E, Ida Chen Y, Talkowski ME, Rotter JI, Krumholz HM, Kathiresan S. Whole Genome Sequencing to Characterize Monogenic and Polygenic Contributions in Patients Hospitalized with Early-Onset Myocardial Infarction. Circulation 2019, 139: 1593-1602. PMID: 30586733, PMCID: PMC6433484, DOI: 10.1161/circulationaha.118.035658.Peer-Reviewed Original Research
2011
An Administrative Claims Measure Suitable for Profiling Hospital Performance Based on 30-Day All-Cause Readmission Rates Among Patients With Acute Myocardial Infarction
Krumholz HM, Lin Z, Drye EE, Desai MM, Han LF, Rapp MT, Mattera JA, Normand SL. An Administrative Claims Measure Suitable for Profiling Hospital Performance Based on 30-Day All-Cause Readmission Rates Among Patients With Acute Myocardial Infarction. Circulation Cardiovascular Quality And Outcomes 2011, 4: 243-252. PMID: 21406673, PMCID: PMC3350811, DOI: 10.1161/circoutcomes.110.957498.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCohort StudiesFemaleHumansInsurance Claim ReviewLogistic ModelsMaleMedicareModels, StatisticalMyocardial InfarctionOutcome and Process Assessment, Health CareOutcome Assessment, Health CarePatient ReadmissionQuality of Health CareReproducibility of ResultsRisk FactorsTime FactorsUnited States
2010
Variation in Recovery
Lichtman JH, Lorenze NP, D'Onofrio G, Spertus JA, Lindau ST, Morgan TM, Herrin J, Bueno H, Mattera JA, Ridker PM, Krumholz HM. Variation in Recovery. Circulation Cardiovascular Quality And Outcomes 2010, 3: 684-693. PMID: 21081748, PMCID: PMC3064946, DOI: 10.1161/circoutcomes.109.928713.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionYoung AMI patientsAMI patientsYoung womenHeart diseaseSex differencesExcess mortality riskIschemic heart diseaseRisk stratification modelPsychosocial risk factorsYears of ageQuality of careComparison cohortPrognostic factorsPrognostic importanceAMI populationMyocardial infarctionRisk factorsObservational studyMortality riskHigh riskAMI eventsPatientsAge accountWomen
2006
Strategies for Reducing the Door-to-Balloon Time in Acute Myocardial Infarction
Bradley EH, Herrin J, Wang Y, Barton BA, Webster TR, Mattera JA, Roumanis SA, Curtis JP, Nallamothu BK, Magid DJ, McNamara RL, Parkosewich J, Loeb JM, Krumholz HM. Strategies for Reducing the Door-to-Balloon Time in Acute Myocardial Infarction. New England Journal Of Medicine 2006, 355: 2308-2320. PMID: 17101617, DOI: 10.1056/nejmsa063117.Peer-Reviewed Original ResearchConceptsST-segment elevationBalloon timeCatheterization laboratoryMyocardial infarctionFaster doorEmergency departmentPrimary percutaneous coronary interventionHospital strategiesIntracoronary balloon inflationPercutaneous coronary interventionAcute myocardial infarctionMinority of hospitalsEmergency medicine physiciansReperfusion treatmentCoronary interventionBalloon inflationMedicine physiciansMultivariate analysisHospitalInfarctionPatientsMedicaid ServicesSignificant reductionReal-time data feedbackData feedbackAn Administrative Claims Model Suitable for Profiling Hospital Performance Based on 30-Day Mortality Rates Among Patients With an Acute Myocardial Infarction
Krumholz HM, Wang Y, Mattera JA, Wang Y, Han LF, Ingber MJ, Roman S, Normand SL. An Administrative Claims Model Suitable for Profiling Hospital Performance Based on 30-Day Mortality Rates Among Patients With an Acute Myocardial Infarction. Circulation 2006, 113: 1683-1692. PMID: 16549637, DOI: 10.1161/circulationaha.105.611186.Peer-Reviewed Original ResearchAchieving Rapid Door-To-Balloon Times
Bradley EH, Curry LA, Webster TR, Mattera JA, Roumanis SA, Radford MJ, McNamara RL, Barton BA, Berg DN, Krumholz HM. Achieving Rapid Door-To-Balloon Times. Circulation 2006, 113: 1079-1085. PMID: 16490818, DOI: 10.1161/circulationaha.105.590133.Peer-Reviewed Original Research
2005
Achieving Door-to-Balloon Times That Meet Quality Guidelines How Do Successful Hospitals Do It?
Bradley EH, Roumanis SA, Radford MJ, Webster TR, McNamara RL, Mattera JA, Barton BA, Berg DN, Portnay EL, Moscovitz H, Parkosewich J, Holmboe ES, Blaney M, Krumholz HM. Achieving Door-to-Balloon Times That Meet Quality Guidelines How Do Successful Hospitals Do It? Journal Of The American College Of Cardiology 2005, 46: 1236-1241. PMID: 16198837, DOI: 10.1016/j.jacc.2005.07.009.Peer-Reviewed Original ResearchQuality Improvement Efforts and Hospital Performance
Bradley EH, Herrin J, Mattera JA, Holmboe ES, Wang Y, Frederick P, Roumanis SA, Radford MJ, Krumholz HM. Quality Improvement Efforts and Hospital Performance. Medical Care 2005, 43: 282-292. PMID: 15725985, DOI: 10.1097/00005650-200503000-00011.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAgedAged, 80 and overCross-Sectional StudiesDrug Utilization ReviewFemaleHospitalsHumansLeadershipMaleMedical Staff, HospitalMiddle AgedMyocardial InfarctionOrganizational CultureOutcome Assessment, Health CarePractice Patterns, Physicians'Quality Indicators, Health CareRegistriesTotal Quality ManagementUnited StatesConceptsAcute myocardial infarctionBeta-blocker prescription ratesQuality improvement effortsMyocardial infarctionBeta-blocker useHospital teaching statusCross-sectional studyQuality improvement interventionsPatient-level dataPhysician leadershipQuality of careHospital performanceHospital quality improvement effortsImprovement effortsQuality improvement strategiesPrescription ratesBorderline significanceNational registryAMI volumeUS hospitalsImprovement interventionsHospitalTeaching statusEvidence baseHigh/medium
2004
Hospital-Level Performance Improvement
Bradley EH, Herrin J, Mattera JA, Holmboe ES, Wang Y, Frederick P, Roumanis SA, Radford MJ, Krumholz HM. Hospital-Level Performance Improvement. Medical Care 2004, 42: 591-599. PMID: 15167327, DOI: 10.1097/01.mlr.0000128006.27364.a9.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAgedAmerican Hospital AssociationCardiology Service, HospitalComorbidityDrug Utilization ReviewFemaleGeographyGuideline AdherenceHealth Care SurveysHumansLogistic ModelsMaleMiddle AgedMyocardial InfarctionPatient DischargeQuality Assurance, Health CareRegistriesSocioeconomic FactorsUnited StatesConceptsBeta-blocker useAcute myocardial infarctionHospital-level variationHospital characteristicsMyocardial infarctionBeta-blocker prescription ratesHospital-level changesHospital-level ratesAmerican Hospital Association Annual SurveyClinical characteristicsPrescription ratesNational registryAMI volumeHospital ratesRate of improvementImprovement rateTeaching statusIndividual hospitalsInfarctionHospitalNational surveyPercentage pointsTime periodUse ratesWeak predictor
2003
What Are Hospitals Doing to Increase Beta-Blocker Use?
Bradley EH, Holmboe ES, Wang Y, Herrin J, Frederick PD, Mattera JA, Roumanis SA, Radford MJ, Krumholz HM. What Are Hospitals Doing to Increase Beta-Blocker Use? The Joint Commission Journal On Quality And Patient Safety 2003, 29: 409-415. PMID: 12953605, DOI: 10.1016/s1549-3741(03)29049-3.Peer-Reviewed Original ResearchConceptsBeta-blocker useQuality improvement interventionsMyocardial infarctionCare coordinatorsClinical pathwayImprovement interventionsAcute myocardial infarctionCross-sectional analysisQuality improvement staffQuality improvement effortsNational registryMedian numberHospitalTelephone surveyInfarctionReminder FormInterventionImprovement effortsRegistryPrevalencePathwayPhysiciansCharacteristics of Physician Leaders Working to Improve the Quality of Care in Acute Myocardial Infarction
Holmboe ES, Bradley EH, Mattera JA, Roumanis SA, Radford MJ, Krumholz HM. Characteristics of Physician Leaders Working to Improve the Quality of Care in Acute Myocardial Infarction. The Joint Commission Journal On Quality And Patient Safety 2003, 29: 289-296. PMID: 14564747, DOI: 10.1016/s1549-3741(03)29033-x.Peer-Reviewed Original ResearchAdrenergic beta-AntagonistsAttitude of Health PersonnelCardiology Service, HospitalClinical CompetenceDrug UtilizationHospital AdministratorsHumansInterdisciplinary CommunicationInterviews as TopicLeadershipMedical Staff, HospitalMyocardial InfarctionNursing Staff, HospitalQualitative ResearchTotal Quality ManagementUnited StatesThe roles of senior management in quality improvement efforts: what are the key components?
Bradley EH, Holmboe ES, Mattera JA, Roumanis SA, Radford MJ, Krumholz HM. The roles of senior management in quality improvement efforts: what are the key components? Journal Of Healthcare Management 2003, 48: 15-28; discussion 29. PMID: 12592866, DOI: 10.1097/00115514-200301000-00005.Peer-Reviewed Original Research
2001
A Qualitative Study of Increasing β-Blocker Use After Myocardial Infarction: Why Do Some Hospitals Succeed?
Bradley EH, Holmboe ES, Mattera JA, Roumanis SA, Radford MJ, Krumholz HM. A Qualitative Study of Increasing β-Blocker Use After Myocardial Infarction: Why Do Some Hospitals Succeed? JAMA 2001, 285: 2604-2611. PMID: 11368734, DOI: 10.1001/jama.285.20.2604.Peer-Reviewed Original ResearchConceptsBeta-blocker useAcute myocardial infarctionMyocardial infarctionΒ-blocker useStrong physician leadershipImprovement effortsUS hospitalsQualitative studyHospitalPatientsHospital sizeImprovement initiativesInfarctionKey physiciansGreater improvementPhysician leadershipCareAdministrative supportUse ratesPerformance improvement effortsData feedbackParticipantsGeographic regionsCliniciansMortality
1988
Demonstration of reperfusion after thrombolysis with technetium-99m isonitrile myocardial imaging.
Kayden D, Mattera J, Zaret B, Wackers F. Demonstration of reperfusion after thrombolysis with technetium-99m isonitrile myocardial imaging. Journal Of Nuclear Medicine 1988, 29: 1865-7. PMID: 2972815.Peer-Reviewed Original ResearchConceptsThrombolytic therapyMyocardial infarctionRecombinant tissue plasminogen activatorAcute anteroseptal myocardial infarctionSuccess of reperfusionSalvage of myocardiumAcute myocardial infarctionAnteroseptal myocardial infarctionMyocardial perfusion defectsMyocardial perfusion imagingTissue plasminogen activatorEmergency roomRepeat injectionsPerfusion defectsIntravenous injectionMyocardial imagingPerfusion imagingMyocardial redistributionInfarctionNoninvasive meansPlasminogen activatorReperfusionImaging agentTherapyTechnetium