2020
First-in-Human Experience With Peritoneal Direct Sodium Removal Using a Zero-Sodium Solution
Rao VS, Turner JM, Griffin M, Mahoney D, Asher J, Jeon S, Yoo PS, Boutagy N, Feher A, Sinusas A, Wilson FP, Finkelstein F, Testani JM. First-in-Human Experience With Peritoneal Direct Sodium Removal Using a Zero-Sodium Solution. Circulation 2020, 141: 1043-1053. PMID: 31910658, PMCID: PMC7331276, DOI: 10.1161/circulationaha.119.043062.Peer-Reviewed Original ResearchConceptsStandard PD solutionExperimental heart failureHeart failurePD solutionsAdverse eventsPeritoneal dialysisSignificant discomfortSodium removalEnd-stage renal diseaseEnd pointElevated right atrial pressureMaintenance of euvolemiaPrimary end pointSecondary end pointsRight atrial pressureHuman proofLoss of responseSolute removalPorcine experimentsAtrial pressureRenal diseaseLoop diureticsSerum electrolytesHuman studiesPeritoneal membrane
2016
We Avoid RAAS Inhibitors in PD Patients with Residual Renal Function
Turner JM. We Avoid RAAS Inhibitors in PD Patients with Residual Renal Function. Seminars In Dialysis 2016, 29: 265-267. PMID: 27061273, DOI: 10.1111/sdi.12488.Commentaries, Editorials and LettersConceptsResidual renal functionPeritoneal dialysisRAAS inhibitorsRenal functionAngiotensin receptor blockersGlomerular filtration rateRAAS blockadeAldosterone systemReceptor blockersNephrotoxic agentsPD patientsPD populationFiltration rateModality failureUltrafiltration failureEnzyme inhibitorsPatientsPeritoneal membraneMorphologic changesInhibitorsMortalityCliniciansAnuriaAngiotensinFailure