The Autism Biomarkers Consortium for Clinical Trials: Initial Evaluation of a Battery of Candidate EEG Biomarkers
Webb SJ, Naples AJ, Levin AR, Hellemann G, Borland H, Benton J, Carlos C, McAllister T, Santhosh M, Seow H, Atyabi A, Bernier R, Chawarska K, Dawson G, Dziura J, Faja S, Jeste S, Murias M, Nelson CA, Sabatos-DeVito M, Senturk D, Shic F, Sugar CA, McPartland JC. The Autism Biomarkers Consortium for Clinical Trials: Initial Evaluation of a Battery of Candidate EEG Biomarkers. American Journal Of Psychiatry 2022, 180: 41-49. PMID: 36000217, PMCID: PMC10027395, DOI: 10.1176/appi.ajp.21050485.Peer-Reviewed Original ResearchConceptsBiological motion perceptionAutism spectrum disorderResting-state activityMotion perceptionEEG biomarkersGroup discriminationPsychometric propertiesBasic psychometric propertiesASD groupASD diagnosisNeural responsesSpectrum disorderAlpha powerN170Naturalistic studyPerceptionMixed resultsTask latencyVEP amplitudeContext of useLimited attentionInconsistent resultsAcquisition rateDiscriminationBatteriesAttention Allocation During Exploration of Visual Arrays in ASD: Results from the ABC-CT Feasibility Study
Tsang T, Naples AJ, Barney EC, Xie M, Bernier R, Dawson G, Dziura J, Faja S, Jeste SS, McPartland JC, Nelson CA, Murias M, Seow H, Sugar C, Webb SJ, Shic F, Johnson SP. Attention Allocation During Exploration of Visual Arrays in ASD: Results from the ABC-CT Feasibility Study. Journal Of Autism And Developmental Disorders 2022, 53: 3220-3229. PMID: 35657448, PMCID: PMC10980886, DOI: 10.1007/s10803-022-05569-0.Peer-Reviewed Original ResearchConceptsExploration paradigmNonsocial stimuliAttention allocationASD groupSocial stimuliTD childrenVisual arrayCognitive skillsObject arraysTypical developmentASDVisual explorationObjective measuresStimuliParadigmChildrenFaceSalienceSkillsRecent workLess timeAttentionMeasuresQuantifying featuresObjectsIdentifying Age Based Maturation in the ERP Response to Faces in Children With Autism: Implications for Developing Biomarkers for Use in Clinical Trials
Webb SJ, Emerman I, Sugar C, Senturk D, Naples AJ, Faja S, Benton J, Borland H, Carlos C, Levin AR, McAllister T, Santhosh M, Bernier RA, Chawarska K, Dawson G, Dziura J, Jeste S, Kleinhans N, Murias M, Sabatos-DeVito M, Shic F, McPartland JC, Trials T. Identifying Age Based Maturation in the ERP Response to Faces in Children With Autism: Implications for Developing Biomarkers for Use in Clinical Trials. Frontiers In Psychiatry 2022, 13: 841236. PMID: 35615454, PMCID: PMC9126041, DOI: 10.3389/fpsyt.2022.841236.Peer-Reviewed Original ResearchAutism spectrum disorderEvent-related potentialsUpright facesTypical developmentASD participantsASD groupProcessing of facesNon-verbal IQERP component latenciesVisual processing systemFace memoryFace processingERP responsesTD childrenAutism spectrumSocial skillsTD groupInversion effectSlower latenciesSpectrum disorderSpecificity effectsAge-related changesNeurodevelopmental conditionsNeural biomarkersComponent latenciesThe Autism Biomarkers Consortium for Clinical Trials: evaluation of a battery of candidate eye-tracking biomarkers for use in autism clinical trials
Shic F, Naples AJ, Barney EC, Chang SA, Li B, McAllister T, Kim M, Dommer KJ, Hasselmo S, Atyabi A, Wang Q, Helleman G, Levin AR, Seow H, Bernier R, Charwaska K, Dawson G, Dziura J, Faja S, Jeste SS, Johnson SP, Murias M, Nelson CA, Sabatos-DeVito M, Senturk D, Sugar CA, Webb SJ, McPartland JC. The Autism Biomarkers Consortium for Clinical Trials: evaluation of a battery of candidate eye-tracking biomarkers for use in autism clinical trials. Molecular Autism 2022, 13: 15. PMID: 35313957, PMCID: PMC10124777, DOI: 10.1186/s13229-021-00482-2.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderBiological motion preferenceSocial interactiveHuman faceMotion preferencesAutism symptom severityPragmatic communication skillsHigher verbal IQAttentional processesASD groupScene tasksVerbal IQTypical developmentSocial scenesSpectrum disorderOculomotor indicesReflex taskStandardized contextEye movementsCommunication skillsConstruct validitySymptom severityTaskPsychiatric conditionsSpecific interventions