2001
Bile salt export pump is highly conserved during vertebrate evolution and its expression is inhibited by PFIC type II mutations
Cai S, Wang L, Ballatori N, Boyer J. Bile salt export pump is highly conserved during vertebrate evolution and its expression is inhibited by PFIC type II mutations. AJP Gastrointestinal And Liver Physiology 2001, 281: g316-g322. PMID: 11447010, DOI: 10.1152/ajpgi.2001.281.2.g316.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsATP Binding Cassette Transporter, Subfamily B, Member 11ATP-Binding Cassette TransportersBiological TransportCholestasis, IntrahepaticCloning, MolecularConserved SequenceEvolution, MolecularHumansLiverMolecular Sequence DataMutationPhylogenyRNA, MessengerSequence Homology, Amino AcidSkates, FishSpodopteraTaurocholic AcidTransfectionConceptsSf9 cellsATP-dependent transport proteinsFull-length cloneATP-dependent export pumpLiver cDNA libraryNorthern blot analysisStructure-function relationshipsVertebrate evolutionEvolutionary originHuman BSEPBile salt export pump BSEPMutant proteinsSkate Raja erinaceaHigher vertebratesCDNA libraryTransport proteinsSixfold stimulationVertebratesType II mutationAmino acidsRaja erinaceaDefective expressionBlot analysisExport pumpMutations
1976
Selective Hepatic Uptake and Biliary Excretion of 35S-Sulfobromophthalein in Marine Elasmobranchs
Boyer J, Schwarz J, Smith N. Selective Hepatic Uptake and Biliary Excretion of 35S-Sulfobromophthalein in Marine Elasmobranchs. Gastroenterology 1976, 70: 254-256. PMID: 1248686, DOI: 10.1016/s0016-5085(76)80019-4.Peer-Reviewed Original ResearchConceptsBinding proteinOrganic anion binding proteinMarine vertebratesHigher vertebratesSpecific binding proteinMarine elasmobranchsPhysiological significanceRaja erinaceaMarine lifeVertebratesElasmobranchsProteinTransport systemOrganic anionsErinaceaSpeciesSelective hepatic uptakeUptakeSkateSqualusDogfishMetabolismMigration