2020
Adaptive Regulation of Hepatocyte Transporters in Cholestasis
Boyer J. Adaptive Regulation of Hepatocyte Transporters in Cholestasis. 2020, 378-389. DOI: 10.1002/9781119436812.ch31.Peer-Reviewed Original ResearchSignal transduction pathwaysAdaptive responseOrganic solute transporterSecretory polarityTranscription factorsTransduction pathwaysMolecular adaptationsSolute transportersCytoskeleton structureIntracellular vesiclesTarget genesMembrane transportersCellular eventsJunctional proteinsNuclear receptorsCanalicular domainCholestatic phenotypeTransportersTight junctionsVital functionsRegulationAdaptive regulationImportant ligandsEnzymatic reactionsBile salt synthesis
2013
Biosynthesis and trafficking of the bile salt export pump, BSEP: Therapeutic implications of BSEP mutations
Soroka CJ, Boyer JL. Biosynthesis and trafficking of the bile salt export pump, BSEP: Therapeutic implications of BSEP mutations. Molecular Aspects Of Medicine 2013, 37: 3-14. PMID: 23685087, PMCID: PMC3784619, DOI: 10.1016/j.mam.2013.05.001.Peer-Reviewed Original ResearchConceptsBenign recurrent intrahepatic cholestasis type 2Progressive familial intrahepatic cholestasis type 2Cell biological aspectsBile salt export pumpTranslational regulationCell biologyMembrane transportersPrimary transporterBile salt-dependent bile flowType 2Bile acidsRate-limiting stepExport pumpDrug-induced cholestasisBiological aspectsBiosynthesisTraffickingTransportersBSEP mutationsMutationsCholestatic diseaseIntrahepatic cholestasisBile flowBiliary systemEnterohepatic circulation
2002
Mechanisms of Hepatic Transport of Drugs: Implications for Cholestatic Drug Reactions
Bohan A, Boyer J. Mechanisms of Hepatic Transport of Drugs: Implications for Cholestatic Drug Reactions. Seminars In Liver Disease 2002, 22: 123-136. PMID: 12016544, DOI: 10.1055/s-2002-30099.Peer-Reviewed Original ResearchConceptsDrug-induced cholestasisCholestatic drug reactionDrug reactionsDrug transporter expressionNumber of drugsBiliary excretionCanalicular transport proteinsAnimal modelsHepatic uptakeHepatobiliary transportersCholestasisTransporter expressionHepatic transportGenetic polymorphismsNormal functionDrugsMajor determinantForeign compoundsStudy of mechanismsTransportersExcretion
1995
Vesicle targeting to the apical domain regulates bile excretory function in isolated rat hepatocyte couplets
Boyer J, Soroka C. Vesicle targeting to the apical domain regulates bile excretory function in isolated rat hepatocyte couplets. Gastroenterology 1995, 109: 1600-1611. PMID: 7557144, DOI: 10.1016/0016-5085(95)90649-5.Peer-Reviewed Original ResearchConceptsInsertion of vesiclesTranslocation of vesiclesMembrane transport activityVesicle trafficApical domainIsolated rat hepatocyte coupletsAcid transportersTransport activityNocodazoleRat hepatocyte coupletsVesiclesIndependent mechanismsEpithelial cellsBile acid transporterSite of residenceHepatocyte coupletsTransportersCanalicular membraneRat hepatocytesImmunocytochemical localizationCyclic monophosphateAdenosine triphosphataseBile excretory function