2023
Organic Anion Transporting Polypeptide (OATP) 1B3 is a Significant Transporter for Hepatic Uptake of Conjugated Bile Acids in Humans
Pan Q, Zhu G, Xu Z, Zhu J, Ouyang J, Tong Y, Zhao N, Zhang X, Cheng Y, Zhang L, Tan Y, Li J, Zhang C, Chen W, Cai S, Boyer J, Chai J. Organic Anion Transporting Polypeptide (OATP) 1B3 is a Significant Transporter for Hepatic Uptake of Conjugated Bile Acids in Humans. Cellular And Molecular Gastroenterology And Hepatology 2023, 16: 223-242. PMID: 37146714, PMCID: PMC10394288, DOI: 10.1016/j.jcmgh.2023.04.007.Peer-Reviewed Original ResearchConceptsBA uptake transportersBile duct ligationHepatic neutrophil infiltrationCholestatic liver injuryProinflammatory cytokine productionCholic acid dietAdaptive protective responseLiver-specific overexpressionWild-type miceConjugated bile acidsUptake transportersPrimary hepatocytesUDCA feedingNeutrophil infiltrationBDL miceLiver injuryCytokine productionBile flowDuct ligationOrganic anion transporting polypeptide (OATP) 1B3Conjugated BAsTransgenic miceHepatic uptakeBile acidsProtective response
1997
Extrahepatic biliary obstruction impairs microvascular perfusion and increases leukocyte adhesion in rat liver
Koeppel T, Trauner M, Baas J, Thies J, Schlosser S, Post S, Gebhard M, Herfarth C, Boyer J, Otto G. Extrahepatic biliary obstruction impairs microvascular perfusion and increases leukocyte adhesion in rat liver. Hepatology 1997, 26: 1085-1091. PMID: 9362346, DOI: 10.1002/hep.510260501.Peer-Reviewed Original ResearchConceptsBile duct ligationIntravital fluorescence microscopyHepatic microvascular perfusionAcute biliary obstructionMicrovascular perfusionLeukocyte adhesionBiliary obstructionIntercellular adhesion molecule-1 protein expressionLeukocyte-endothelial cell interactionsMale Wistar ratsHydrogen gas clearanceICAM-1 expressionSham-operated controlsRat liverWestern blot analysisSinusoidal perfusionNeutrophil infiltrationLiver injuryHepatic microcirculationLiver damageLiver microcirculationTissue immunofluorescenceDuct ligationWistar ratsMarked impairment