2016
Incorporating Androgen Deprivation With Dose-Escalated External-Beam Radiotherapy for Prostate Cancer
Dosoretz A, Yu J. Incorporating Androgen Deprivation With Dose-Escalated External-Beam Radiotherapy for Prostate Cancer. Journal Of Clinical Oncology 2016, 34: 1718-1722. PMID: 27001587, DOI: 10.1200/jco.2015.66.3237.Peer-Reviewed Original ResearchConceptsExternal-beam radiotherapyDigital rectal examinationPalpable diseaseRectal examinationGleason 3+3 diseaseOncology Grand Rounds seriesHigh-grade prostate cancerMagnetic resonance imaging-ultrasound fusionMultiparametric magnetic resonance imagingAdjacent normal prostatePositive biopsy coresUltrasound-guided biopsyInguinal hernia repairT2-weighted imagesJournal of Clinical OncologyPatient's medical historyMagnetic resonance imagingHypointense featuresGleason 4Prostate volumePSA levelsAndrogen deprivationCataract surgeryIntraprostatic lesionsBiopsy cores
2015
Gleason score 5 + 3 = 8 prostate cancer: much more like Gleason score 9?
Mahal B, Muralidhar V, Chen Y, Choueiri T, Hoffman K, Hu J, Sweeney C, Yu J, Feng F, Trinh Q, Nguyen P. Gleason score 5 + 3 = 8 prostate cancer: much more like Gleason score 9? BJU International 2015, 118: 95-101. PMID: 26207642, DOI: 10.1111/bju.13239.Peer-Reviewed Original ResearchConceptsProstate cancer-specific mortalityGleason score 5Risk of prostate cancer-specific mortalityGleason score 4Prostate cancerScore 5Increased risk of PCSMGray competing risk regression analysisProstate cancer-specific mortality outcomesProstate cancer-specific mortality ratesScore 4Competing risk regression analysisGleason score 3Gleason score 8Gleason score 9Primary Gleason patternReference group of patientsCancer-specific mortalityAggressive treatment strategiesGroup of patientsRisk regression analysisHighest-risk patientsGleason 4Gleason scoreGleason pattern