2023
Natural isoaspartyl protein modification of ZAP70 alters T cell responses in lupus
Yang M, Lam T, Kanyo J, Kang I, Zhou Z, Clarke S, Mamula M. Natural isoaspartyl protein modification of ZAP70 alters T cell responses in lupus. Autoimmunity 2023, 56: 2282945. PMID: 37994408, PMCID: PMC10897934, DOI: 10.1080/08916934.2023.2282945.Peer-Reviewed Original Research
2007
Down-Regulation of IL-7Rα Expression in Human T Cells via DNA Methylation
Kim HR, Hwang KA, Kim KC, Kang I. Down-Regulation of IL-7Rα Expression in Human T Cells via DNA Methylation. The Journal Of Immunology 2007, 178: 5473-5479. PMID: 17442928, DOI: 10.4049/jimmunol.178.9.5473.Peer-Reviewed Original ResearchConceptsJurkat T cellsDNA methylationGene expressionGene promoterIL-7Ralpha expressionT cellsPromoter activityImportant gene regulatory mechanismGene regulatory mechanismsGene promoter constructsHuman CD8Gene promoter activityIL-7Cell survival responseT cell developmentT cell subsetsIL-7Rα expressionRegulatory mechanismsPromoter constructsCell developmentMethylationLuciferase reporterHuman T cellsSurvival responseDown regulation