2018
Interleukin-1 and IL-23 induce innate-like immune responses by bystander-activated memory CD4+ T cells contributing to the autoimmune pathogenesis
Lee H, Lee J, Kang I, Choi J. Interleukin-1 and IL-23 induce innate-like immune responses by bystander-activated memory CD4+ T cells contributing to the autoimmune pathogenesis. The Journal Of Immunology 2018, 200: 51.7-51.7. DOI: 10.4049/jimmunol.200.supp.51.7.Peer-Reviewed Original ResearchT cellsT cell antigen receptorIL-17AIL-23Memory CD4IL-1βImmune responseAutoimmune disease pathogenesisPro-inflammatory cytokinesIFN-γ expressionNaïve T cellsT cell activationAutoimmune neuroinflammationImmunopathological roleTh17 cellsAutoimmune pathogenesisBystander activationBystander CD4T lymphocytesIL-1Interleukin-1CD4Disease pathogenesisCell activationCell antigen receptor
2013
Studying the Role for CD4+ T Cell Subsets in Human Lupus
Kang I. Studying the Role for CD4+ T Cell Subsets in Human Lupus. 2013 DOI: 10.21236/ada585488.Peer-Reviewed Original ResearchIL-27IL-1Autoimmune complexesTh17 cellsLupus patientsPro-inflammatory cytokines IL-1Human monocytesExogenous IL-27IL-17 productionTh cell responsesT cell subsetsToll-like receptorsProduction of cytokinesIL-27 geneCytokines IL-1IL-1 expressionPotential therapeutic implicationsIL-10Human lupusCell subsetsPolarizing cytokinesT cellsHuman CD4Therapeutic implicationsPatients
2010
Age-associated alteration in naive and memory Th17 cell response in humans (85.8)
Lee J, Lee W, Kim S, Kang S, Kang I. Age-associated alteration in naive and memory Th17 cell response in humans (85.8). The Journal Of Immunology 2010, 184: 85.8-85.8. DOI: 10.4049/jimmunol.184.supp.85.8.Peer-Reviewed Original ResearchRisk of infectionT cellsIL-17Naive CD4Peripheral bloodCell responsesIL-17-producing CD4IL-17-producing cellsFrequency of IFNTh17-polarizing cytokinesT cell immunityIFN-γ levelsT cell subsetsPMA/ionomycin stimulationAge-associated alterationsT cell receptorTh17 cellsCell immunityMemory CD4Tissue culture supernatantsAutoimmune diseasesCell subsetsMemory subsetsCD4Extracellular microorganismsDysregulated balance of Th17 and Th1 cells in systemic lupus erythematosus
Shah K, Lee WW, Lee SH, Kim SH, Kang SW, Craft J, Kang I. Dysregulated balance of Th17 and Th1 cells in systemic lupus erythematosus. Arthritis Research & Therapy 2010, 12: r53. PMID: 20334681, PMCID: PMC2888202, DOI: 10.1186/ar2964.Peer-Reviewed Original ResearchConceptsSystemic lupus erythematosusSLE Disease Activity Index (SLEDAI) scorePeripheral blood mononuclear cellsTh17-polarizing cytokinesTh1 cell responsesDisease activityT cellsHealthy subjectsIL-17Th1 cellsCell responsesPhorbol myristate acetateTh17 cellsLupus erythematosusIL-6Plasma levelsDisease activity index scoreBalance of CD4Balance of Th17Expression of Th17Th17 cell responseActivity index scoreFrequency of CD4Chemokine receptor CCR4Blood mononuclear cells