2011
Expansion of IL-7Ralow memory CD8 T cells in human lupus (101.19)
Lee N, Shah K, Shin M, Kim S, Craft J, Kang I. Expansion of IL-7Ralow memory CD8 T cells in human lupus (101.19). The Journal Of Immunology 2011, 186: 101.19-101.19. DOI: 10.4049/jimmunol.186.supp.101.19.Peer-Reviewed Original ResearchSystemic lupus erythematosusDevelopment of SLESLE Disease Activity IndexMemory CD8SLE patientsT cellsCell subsetsHealthy controlsImmunopathogenesis of SLEAbstract Systemic lupus erythematosusHomeostatic cytokine IL-15IL-7 receptor alphaMemory CD8 T cellsCytotoxic molecules perforinHomeostasis of CD8Disease activity indexRole of CD8Cytokine IL-15CD8 T cellsImmune complex depositionProduction of autoantibodiesInflammatory autoimmune disorderT cell receptorDisease activityLupus erythematosus
2010
Age-associated alteration in naive and memory Th17 cell response in humans (85.8)
Lee J, Lee W, Kim S, Kang S, Kang I. Age-associated alteration in naive and memory Th17 cell response in humans (85.8). The Journal Of Immunology 2010, 184: 85.8-85.8. DOI: 10.4049/jimmunol.184.supp.85.8.Peer-Reviewed Original ResearchRisk of infectionT cellsIL-17Naive CD4Peripheral bloodCell responsesIL-17-producing CD4IL-17-producing cellsFrequency of IFNTh17-polarizing cytokinesT cell immunityIFN-γ levelsT cell subsetsPMA/ionomycin stimulationAge-associated alterationsT cell receptorTh17 cellsCell immunityMemory CD4Tissue culture supernatantsAutoimmune diseasesCell subsetsMemory subsetsCD4Extracellular microorganisms
2005
Altered IL-7Rα expression with aging and the potential implications of IL-7 therapy on CD8+ T-cell immune responses
Kim HR, Hong MS, Dan JM, Kang I. Altered IL-7Rα expression with aging and the potential implications of IL-7 therapy on CD8+ T-cell immune responses. Blood 2005, 107: 2855-2862. PMID: 16357322, PMCID: PMC1440715, DOI: 10.1182/blood-2005-09-3560.Peer-Reviewed Original ResearchConceptsIL-7 therapyT cellsT cell receptorIL-7T cell immune responsesEffector memory CD8T cell immunityT cell subsetsIL-7Rα expressionDiverse TCR repertoireIL-7Ralpha expressionIL-7Ralpha mRNAMemory CD8TCR repertoireElderly subjectsCD8Immune responseSurvival responseYoung subjectsImpaired signalingSTAT5 phosphorylationTherapyProtein alphaSurvival pathwaysCells