2013
Defining cellular characteristics of human IL-7Rαlow memory CD8+ T cells using a genome-wide DNA methylation analysis (P1432)
Yoo S, You S, Shin M, Lee N, Kang K, Hwang D, Kang I. Defining cellular characteristics of human IL-7Rαlow memory CD8+ T cells using a genome-wide DNA methylation analysis (P1432). The Journal Of Immunology 2013, 190: 117.16-117.16. DOI: 10.4049/jimmunol.190.supp.117.16.Peer-Reviewed Original ResearchDNA methylationGenome-wide DNA methylation analysisHeritable epigenetic informationPredominant epigenetic mechanismsAbstract DNA methylationDNA methylation analysisEpigenetic informationEpigenetic mechanismsGene promoterMethylation profilingGene expressionTCR triggeringMethylationMethylation analysisGenesHuman agingMemory CD8Cellular characteristicsT cellsCell subsetsIL-7Rα expressionImportant mechanismCellsPotential roleIL-7Rα
2012
U1-snRNP activates the NLRP3 inflammasome in human monocytes (171.7)
Shin M, Kang Y, Lee N, Kang K, Lazova R, Kang I. U1-snRNP activates the NLRP3 inflammasome in human monocytes (171.7). The Journal Of Immunology 2012, 188: 171.7-171.7. DOI: 10.4049/jimmunol.188.supp.171.7.Peer-Reviewed Original ResearchSystemic lupus erythematosusIL-1β productionU1 snRNPAutoimmune diseasesIL-1βCaspase-1Human monocytesReactive oxygen speciesU1 small nuclear RNAU1 small nuclear ribonucleoproteinCytosolic protein complexesLupus erythematosusNLRP3 inflammasomeMicrobial nucleic acidsNLRP3Protein complexesNuclear RNANuclear ribonucleoproteinPre-mRNAEndogenous DNAMonocytesAntibodiesPotential roleCD14Inflammasome
2011
Studying the mechanisms for increased IL-7Rαlow Memory CD8+T cells in the elderly (150.11)
Shin M, Lee W, Lee J, Kim S, Lee N, Kang I. Studying the mechanisms for increased IL-7Rαlow Memory CD8+T cells in the elderly (150.11). The Journal Of Immunology 2011, 186: 150.11-150.11. DOI: 10.4049/jimmunol.186.supp.150.11.Peer-Reviewed Original ResearchMemory CD8T cellsAge-associated expansionYoung donorsCMV infectionIL-15Elderly donorsIL-15-mediated proliferationT cell receptor repertoireTCR-mediated proliferationIL-15 expressionCell receptor repertoireCell subsetsCD8Better survivalReceptor repertoireCMVElderly peoplePotential roleSignificant differencesIndependent mechanismsInfectionProliferationSurvivalCells