Cysteinyl Leukotrienes Regulate Th2 Cell-Dependent Pulmonary Inflammation
Kim DC, Hsu FI, Barrett NA, Friend DS, Grenningloh R, Ho IC, Al-Garawi A, Lora JM, Lam BK, Austen KF, Kanaoka Y. Cysteinyl Leukotrienes Regulate Th2 Cell-Dependent Pulmonary Inflammation. The Journal Of Immunology 2006, 176: 4440-4448. PMID: 16547282, DOI: 10.4049/jimmunol.176.7.4440.Peer-Reviewed Original ResearchConceptsPulmonary inflammationDelayed-type cutaneous hypersensitivityAg-specific IgECys-LT generationSmooth muscle constrictorTh2 cell cytokinesGoblet cell hyperplasiaIntraepithelial mast cellsCytokine mRNA expressionCell-dependent responsesAirway hyperresponsivenessOVA sensitizationWild-type controlsCutaneous hypersensitivityCys-LTsMucus hypersecretionEosinophil infiltrationCell hyperplasiaCysteinyl leukotrienesCell cytokinesInflammatory responseMast cellsInflammationChallenge protocolMRNA expression