Specialized endothelial tip cells guide neuroretina vascularization and blood-retina-barrier formation
Zarkada G, Howard JP, Xiao X, Park H, Bizou M, Leclerc S, Künzel SE, Boisseau B, Li J, Cagnone G, Joyal JS, Andelfinger G, Eichmann A, Dubrac A. Specialized endothelial tip cells guide neuroretina vascularization and blood-retina-barrier formation. Developmental Cell 2021, 56: 2237-2251.e6. PMID: 34273276, PMCID: PMC9951594, DOI: 10.1016/j.devcel.2021.06.021.Peer-Reviewed Original ResearchConceptsSuperficial retinal vascular plexusRetinal vascular plexusTGF-β receptor IRetinal vascular developmentEndothelial tip cellsMouse neuroretinaIschemic retinopathyRetinal revascularizationVascular malformationsAngiogenic therapyReceptor IUnique transcriptional signatureVascular plexusNeural functionPericyte differentiationTranscriptional signatureComplex branching patternsRevascularizationEndothelial deletionPlexus formationSmad effectorsTissue vascularizationPrimary targetVascular developmentBranching patternDefective Flow-Migration Coupling Causes Arteriovenous Malformations in Hereditary Hemorrhagic Telangiectasia
Park H, Furtado J, Poulet M, Chung M, Yun S, Lee S, Sessa WC, Franco CA, Schwartz MA, Eichmann A. Defective Flow-Migration Coupling Causes Arteriovenous Malformations in Hereditary Hemorrhagic Telangiectasia. Circulation 2021, 144: 805-822. PMID: 34182767, PMCID: PMC8429266, DOI: 10.1161/circulationaha.120.053047.Peer-Reviewed Original ResearchConceptsActivin receptor-like kinase 1Hereditary hemorrhagic telangiectasiaHemorrhagic telangiectasiaVascular malformationsArteriovenous malformationsBlood flowGrowth factor receptor 2Endothelial growth factor receptor 2Vascular endothelial growth factor receptor 2Factor receptor 2Receptor-like kinase 1New potential targetsYAP/TAZ nuclear translocationDeficient miceTransmembrane serine-threonine kinase receptorsDevastating disorderAlk1 deletionReceptor 2Pharmacologic inhibitionCre linesPostnatal retinaMalformationsSerine-threonine kinase receptorsEndothelial cell migrationNuclear translocation