Specialized endothelial tip cells guide neuroretina vascularization and blood-retina-barrier formation
Zarkada G, Howard JP, Xiao X, Park H, Bizou M, Leclerc S, Künzel SE, Boisseau B, Li J, Cagnone G, Joyal JS, Andelfinger G, Eichmann A, Dubrac A. Specialized endothelial tip cells guide neuroretina vascularization and blood-retina-barrier formation. Developmental Cell 2021, 56: 2237-2251.e6. PMID: 34273276, PMCID: PMC9951594, DOI: 10.1016/j.devcel.2021.06.021.Peer-Reviewed Original ResearchConceptsSuperficial retinal vascular plexusRetinal vascular plexusTGF-β receptor IRetinal vascular developmentEndothelial tip cellsMouse neuroretinaIschemic retinopathyRetinal revascularizationVascular malformationsAngiogenic therapyReceptor IUnique transcriptional signatureVascular plexusNeural functionPericyte differentiationTranscriptional signatureComplex branching patternsRevascularizationEndothelial deletionPlexus formationSmad effectorsTissue vascularizationPrimary targetVascular developmentBranching pattern