2008
A Randomized Controlled Trial of Glucose versus Amylase Resistant Starch Hypo-Osmolar Oral Rehydration Solution for Adult Acute Dehydrating Diarrhea
Ramakrishna BS, Subramanian V, Mohan V, Sebastian BK, Young GP, Farthing MJ, Binder HJ. A Randomized Controlled Trial of Glucose versus Amylase Resistant Starch Hypo-Osmolar Oral Rehydration Solution for Adult Acute Dehydrating Diarrhea. PLOS ONE 2008, 3: e1587. PMID: 18270575, PMCID: PMC2217593, DOI: 10.1371/journal.pone.0001587.Peer-Reviewed Original ResearchConceptsHypo-osmolar ORSOral rehydration solutionCholera-like diarrheaDiarrhea durationDehydrating diarrheaFecal weightRehydration solutionDuration of diarrheaTertiary referral hospitalSevere dehydrating diarrheaSevere watery diarrheaAmylase-resistant starchAcute dehydrating diarrheaSimilar significant differencesORS intakeORS therapyControlled TrialsIntravenous therapyReferral hospitalAppropriate antibioticsRehydration therapyWatery diarrheaStool weightSubgroup analysisClinical trials
2006
Amylase‐Resistant Starch as Adjunct to Oral Rehydration Therapy in Children with Diarrhea
Raghupathy P, Ramakrishna BS, Oommen SP, Ahmed MS, Priyaa G, Dziura J, Young GP, Binder HJ. Amylase‐Resistant Starch as Adjunct to Oral Rehydration Therapy in Children with Diarrhea. Journal Of Pediatric Gastroenterology And Nutrition 2006, 42: 362-368. PMID: 16641573, DOI: 10.1097/01.mpg.0000214163.83316.41.Peer-Reviewed Original ResearchConceptsOral rehydration solutionAmylase-resistant starchGlucose-ORSDuration of diarrheaStool weightAcute diarrheaStandard treatmentFluid absorptionG-ORS groupMean stool weightIntravenous fluid therapyAcute watery diarrheaOral rehydration therapySeverity of diarrheaTreatment of diarrheaShort-chain fatty acidsColonic sodiumEvaluable dataRehydration therapyTreatment failureFluid therapyWatery diarrheaRehydration solutionIntestinal sodiumDiarrhea
1990
Pathophysiology of acute diarrhea
Binder H. Pathophysiology of acute diarrhea. The American Journal Of Medicine 1990, 88: s2-s4. PMID: 2356845, DOI: 10.1016/0002-9343(90)90267-h.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAntidiarrhealsDiarrheaGastrointestinal MotilityHumansIntestinal AbsorptionWater-Electrolyte BalanceConceptsFluid absorptionAcute infectious diarrheaMajor health problemSpecific pathogenic mechanismsElectrolyte movementStool consistencyStool frequencyIntestinal motilityStool volumeAcute diarrheaIntestinal secretionInfectious diarrheaAntidiarrheal agentsWater excretionDiarrheaPathogenic mechanismsInfectious agentsHealth problemsIntestinal tractEpithelial cellsTissue invasionLuminal osmolalitySymptomsEnterotoxin productionSigns
1986
Effect of glucocorticoids on rectal transport in normal subjects and patients with ulcerative colitis.
Sandle G, Hayslett J, Binder H. Effect of glucocorticoids on rectal transport in normal subjects and patients with ulcerative colitis. Gut 1986, 27: 309. PMID: 3699552, PMCID: PMC1433405, DOI: 10.1136/gut.27.3.309.Peer-Reviewed Original ResearchConceptsActive ulcerative colitisInactive ulcerative colitisUlcerative colitisControl subjectsPharmacological dosesIntravenous administrationNet sodiumAcute ulcerative colitisAnti-inflammatory actionEffects of glucocorticoidsNet sodium absorptionColonic sodiumRectal pdAcute increaseAcute effectsColitisHydrocortisone hemisuccinateNormal subjectsPatientsGlucocorticoid hormonesSodium absorptionNet electrolyteGlucocorticoidsSimilar increaseSimilar changes
1975
Glucagon secretion in acute and chronic pancreatitis.
Donowitz M, Hendler R, Spiro H, Binder H, Felig P. Glucagon secretion in acute and chronic pancreatitis. Annals Of Internal Medicine 1975, 83: 778-81. PMID: 1200523, DOI: 10.7326/0003-4819-83-6-778.Peer-Reviewed Original ResearchConceptsAcute pancreatitisPancreatic insufficiencyAlpha-cell responsivenessChronic pancreatic insufficiencyBasal glucagon levelsPancreatic glucagon concentrationsInfusion of alaninePrevious pancreatitisGlucagon responseAcute episodeGlucagon levelsGlucagon secretionChronic pancreatitisPlasma glucagonGlucagon concentrationsInitial episodeHealthy controlsPancreatitisCell responsivenessPatientsBasal statePrevious attacksSensitive indexInitial attackInsufficiencyA Controlled Evaluation of Intravenous Adrenocorticotropic Hormone and Hydrocortisone in the Treatment of Acute Colitis
Kaplan H, Portnoy B, Binder H, Amatruda T, Spiko H. A Controlled Evaluation of Intravenous Adrenocorticotropic Hormone and Hydrocortisone in the Treatment of Acute Colitis. Gastroenterology 1975, 69: 91-95. PMID: 168121, DOI: 10.1016/s0016-5085(19)32640-x.Peer-Reviewed Original ResearchConceptsIntravenous adrenocorticotropic hormoneAdrenocorticotropic hormoneSymptomatic inflammatory bowel diseaseSystemic steroid levelsInflammatory bowel diseaseDouble-blind techniqueTreatment of patientsConsecutive hospital patientsPlasma cortisol levelsIntravenous hydrocortisoneTherapeutic lagAcute colitisBowel diseasePatient evaluationHospital patientsDrug dosesControlled EvaluationEquivalent dosageSteroid levelsCortisol levelsExcretion rateDrug selectionHydrocortisonePatientsBlind technique