2014
Impact of Coronary Lesion Complexity on Drug-Eluting Stent Outcomes in Patients With and Without Diabetes Mellitus Analysis From 18 Pooled Randomized Trials
Kedhi E, Généreux P, Palmerini T, McAndrew T, Parise H, Mehran R, Dangas G, Stone G. Impact of Coronary Lesion Complexity on Drug-Eluting Stent Outcomes in Patients With and Without Diabetes Mellitus Analysis From 18 Pooled Randomized Trials. Journal Of The American College Of Cardiology 2014, 63: 2111-2118. PMID: 24632279, DOI: 10.1016/j.jacc.2014.01.064.Peer-Reviewed Original ResearchConceptsDiabetes mellitusRepeat revascularizationMyocardial infarctionLesion complexityStent outcomesCardiac deathType A/B1 lesionsType B2/C lesionsB2/C lesionsPropensity score-matched groupsCoronary lesion complexityTarget vessel revascularizationPatient-level dataB1 lesionsNoncomplex lesionsVessel revascularizationDiabetic statusC lesionsDES eraRandomized trialsRisk factorsTarget lesionsDES safetyTreatment outcomesBaseline differences
2013
Impact of Bivalirudin and Paclitaxel-Eluting Stents on Outcomes in Patients Undergoing Primary Percutaneous Coronary Intervention of the Left Anterior Descending Artery
Wöhrle J, Brodie B, Witzenbichler B, Dudek D, Kornowski R, Metzger C, Grines C, McAndrew T, Parise H, Sergie Z, Mehran R, Stone G. Impact of Bivalirudin and Paclitaxel-Eluting Stents on Outcomes in Patients Undergoing Primary Percutaneous Coronary Intervention of the Left Anterior Descending Artery. The American Journal Of Cardiology 2013, 112: 753-760. PMID: 23746479, DOI: 10.1016/j.amjcard.2013.05.006.Peer-Reviewed Original ResearchMeSH KeywordsAgedAntineoplastic Agents, PhytogenicAntithrombinsCoronary AngiographyCoronary VesselsDrug-Eluting StentsElectrocardiographyFemaleFollow-Up StudiesHirudinsHumansMaleMiddle AgedMyocardial InfarctionPaclitaxelPeptide FragmentsPercutaneous Coronary InterventionProspective StudiesRecombinant ProteinsTreatment OutcomeConceptsPrimary percutaneous coronary interventionST-elevation myocardial infarctionPaclitaxel-eluting stentingImpact of bivalirudinTarget vessel revascularizationPercutaneous coronary interventionVessel revascularizationCoronary interventionCardiac deathPrimary PCIGlycoprotein IIb/IIIa inhibitorsIschemia-driven target vessel revascularizationIIb/IIIa inhibitorsLeft anterior descending (LAD) arteryHORIZONS-AMI trialMajor bleeding eventsUse of bivalirudinAnterior descending (LAD) arteryElevation myocardial infarctionBare-metal stentingSignificant lower rateLower ratesBleeding eventsCardiovascular eventsRevascularization rates
2012
Characteristics and Outcomes of Patients With ST-Segment Elevation Myocardial Infarction Excluded from the Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction (HORIZONS-AMI) Trial
Fiocca L, Guagliumi G, Rossini R, Parise H, Musumeci G, Sirbu V, Lortkipanidze N, Yu J, Mihalcsik L, Vassileva A, Valsecchi O, Gavazzi A, Mehran R, Stone G. Characteristics and Outcomes of Patients With ST-Segment Elevation Myocardial Infarction Excluded from the Harmonizing Outcomes With Revascularization and Stents in Acute Myocardial Infarction (HORIZONS-AMI) Trial. The American Journal Of Cardiology 2012, 111: 196-201. PMID: 23111141, DOI: 10.1016/j.amjcard.2012.09.019.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionAcute Myocardial Infarction trialKillip class IIIMyocardial Infarction trialOutcomes of patientsElevation myocardial infarctionHarmonizing OutcomesMyocardial infarctionMyocardial Infarction flow grade 3Major adverse cardiovascular eventsNet adverse clinical eventsClass IIIHORIZONS-AMI trialTrial eligible groupAdverse cardiovascular eventsHigh-risk featuresAdverse clinical eventsVentricular ejection fractionBroad inclusion criteriaFinal ThrombolysisMajor bleedingCardiovascular eventsCause mortalityAdverse eventsBaseline characteristicsImpact of major bleeding and blood transfusions after cardiac surgery: Analysis from the Acute Catheterization and Urgent Intervention Triage strategY (ACUITY) trial
Stone G, Clayton T, Mehran R, Dangas G, Parise H, Fahy M, Pocock S. Impact of major bleeding and blood transfusions after cardiac surgery: Analysis from the Acute Catheterization and Urgent Intervention Triage strategY (ACUITY) trial. American Heart Journal 2012, 163: 522-529. PMID: 22424026, DOI: 10.1016/j.ahj.2011.11.016.Peer-Reviewed Original ResearchConceptsRed blood cell transfusionAcute coronary syndromeBlood cell transfusionMajor bleedingRBC transfusionCell transfusionCoronary syndromeCardiac surgerySubsequent mortalityUrgent Intervention Triage Strategy (ACUITY) trialAllogeneic blood product transfusionInternational prospective trialsCoronary artery bypassMajor hemorrhagic complicationsOne-year mortalityBlood product transfusionCovariate-adjusted Cox modelsPrior retrospective studiesFresh frozen plasmaAcute CatheterizationArtery bypassHemorrhagic complicationsProduct transfusionHospital dischargeProspective trial
2011
Impact of Diabetes Mellitus on the Safety and Effectiveness of Bivalirudin in Patients With Acute Myocardial Infarction Undergoing Primary Angioplasty Analysis From the HORIZONS-AMI (Harmonizing Outcomes with RevasculariZatiON and Stents in Acute Myocardial Infarction) Trial
Witzenbichler B, Mehran R, Guagliumi G, Dudek D, Huber K, Kornowski R, Stuckey T, Fahy M, Parise H, Stone G. Impact of Diabetes Mellitus on the Safety and Effectiveness of Bivalirudin in Patients With Acute Myocardial Infarction Undergoing Primary Angioplasty Analysis From the HORIZONS-AMI (Harmonizing Outcomes with RevasculariZatiON and Stents in Acute Myocardial Infarction) Trial. JACC Cardiovascular Interventions 2011, 4: 760-768. PMID: 21777884, DOI: 10.1016/j.jcin.2011.04.008.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngioplasty, Balloon, CoronaryAntithrombinsCoronary AngiographyDiabetes MellitusDose-Response Relationship, DrugDouble-Blind MethodElectrocardiographyFemaleFollow-Up StudiesHirudinsHumansHypoglycemic AgentsMaleMiddle AgedMyocardial InfarctionPeptide FragmentsProspective StudiesRecombinant ProteinsStentsSurvival RateTime FactorsTreatment OutcomeConceptsGlycoprotein IIb/IIIa inhibitorsST-segment elevation myocardial infarctionPrimary percutaneous coronary interventionHORIZONS-AMI trialDiabetes mellitusDiabetic patientsMyocardial infarctionPrimary PCIMajor adverse cardiac eventsIIb/IIIa inhibitorsEffectiveness of bivalirudinEfficacy of bivalirudinAdverse cardiac eventsAcute coronary syndromeElevation myocardial infarctionPercutaneous coronary interventionAcute myocardial infarctionMajor bleedingCardiac mortalityCoronary syndromeAnticoagulant therapyCardiac eventsCoronary interventionCardiac deathUnfractionated heparinHeparin plus a glycoprotein IIb/IIIa inhibitor versus bivalirudin monotherapy and paclitaxel-eluting stents versus bare-metal stents in acute myocardial infarction (HORIZONS-AMI): final 3-year results from a multicentre, randomised controlled trial
Stone G, Witzenbichler B, Guagliumi G, Peruga J, Brodie B, Dudek D, Kornowski R, Hartmann F, Gersh B, Pocock S, Dangas G, Wong S, Fahy M, Parise H, Mehran R, Investigators O. Heparin plus a glycoprotein IIb/IIIa inhibitor versus bivalirudin monotherapy and paclitaxel-eluting stents versus bare-metal stents in acute myocardial infarction (HORIZONS-AMI): final 3-year results from a multicentre, randomised controlled trial. The Lancet 2011, 377: 2193-2204. PMID: 21665265, DOI: 10.1016/s0140-6736(11)60764-2.Peer-Reviewed Original ResearchMeSH KeywordsAngioplasty, BalloonCombined Modality TherapyConfidence IntervalsDose-Response Relationship, DrugDrug Administration ScheduleDrug Therapy, CombinationDrug-Eluting StentsElectrocardiographyFemaleFollow-Up StudiesHeparinHirudinsHumansKaplan-Meier EstimateMaleMyocardial InfarctionPaclitaxelPeptide FragmentsPlatelet Glycoprotein GPIIb-IIIa ComplexProspective StudiesRecombinant ProteinsStentsSurvival AnalysisTime FactorsTreatment OutcomeConceptsST-segment elevation myocardial infarctionGlycoprotein IIb/IIIa inhibitorsPrimary percutaneous coronary interventionIIb/IIIa inhibitorsPercutaneous coronary interventionPaclitaxel-eluting stentsBare metal stentsBivalirudin monotherapyStent thrombosisCoronary interventionMyocardial infarctionIschaemia-driven target lesion revascularisationIschaemia-driven target vessel revascularisationMajor adverse cardiovascular eventsComposite adverse eventsHORIZONS-AMI trialPaclitaxel-eluting stentingTarget vessel revascularisationAdverse cardiovascular eventsBypass graft surgeryTarget lesion revascularisationElevation myocardial infarctionOnset of symptomsKaplan-Meier estimatesAcute myocardial infarctionMeta-Analysis of Randomized Studies Comparing Intravascular Ultrasound Versus Angiographic Guidance of Percutaneous Coronary Intervention in Pre–Drug-Eluting Stent Era
Parise H, Maehara A, Stone G, Leon M, Mintz G. Meta-Analysis of Randomized Studies Comparing Intravascular Ultrasound Versus Angiographic Guidance of Percutaneous Coronary Intervention in Pre–Drug-Eluting Stent Era. The American Journal Of Cardiology 2011, 107: 374-382. PMID: 21257001, DOI: 10.1016/j.amjcard.2010.09.030.Peer-Reviewed Original ResearchConceptsBare metal stent implantationMetal stent implantationMajor adverse cardiac eventsAdverse cardiac eventsPercutaneous coronary interventionIVUS guidanceStent implantationAngiographic restenosisCardiac eventsCoronary interventionMyocardial infarctionIntravascular ultrasoundOverall major adverse cardiac eventsSingle-center studyAcute procedural resultsMinimum lumen diameterRevascularization ratesStent eraBalloon angioplastyProcedural resultsStent studiesAngiographic guidanceNoninferiority trialMeta-AnalysisLumen diameter
2004
Mitral annular calcification is a predictor for incident atrial fibrillation
Fox C, Parise H, Vasan R, Levy D, O’Donnell C, D’Agostino R, Plehn J, Benjamin E. Mitral annular calcification is a predictor for incident atrial fibrillation. Atherosclerosis 2004, 173: 291-294. PMID: 15064104, DOI: 10.1016/j.atherosclerosis.2003.12.018.Peer-Reviewed Original ResearchMeSH KeywordsAge DistributionAgedAged, 80 and overAtrial FibrillationCalcinosisCohort StudiesComorbidityEchocardiography, DopplerElectrocardiographyFemaleFollow-Up StudiesHumansIncidenceMaleMiddle AgedMitral Valve StenosisProbabilityProportional Hazards ModelsRetrospective StudiesRisk AssessmentSeverity of Illness IndexSex DistributionConceptsMitral annular calcificationIncident atrial fibrillationAtrial fibrillationAnnular calcificationAdverse cardiovascular disease outcomesSex-adjusted incidence ratesRisk of AFLeft atrial sizeMultivariable-adjusted analysesCardiac valvular calcificationCardiovascular disease outcomesCommunity-based cohortM-mode echocardiographyProportional hazards modelLong-term riskFramingham Heart StudyIncident AFHazard ratioAtrial enlargementAtrial sizeEchocardiographic assessmentValvular calcificationOriginal cohortProspective dataIncidence rate
2003
Cytokines, insulin-like growth factor 1, sarcopenia, and mortality in very old community-dwelling men and women: the Framingham Heart Study
Roubenoff R, Parise H, Payette H, Abad L, D'Agostino R, Jacques P, Wilson P, Dinarello C, Harris T. Cytokines, insulin-like growth factor 1, sarcopenia, and mortality in very old community-dwelling men and women: the Framingham Heart Study. The American Journal Of Medicine 2003, 115: 429-435. PMID: 14563498, DOI: 10.1016/j.amjmed.2003.05.001.Peer-Reviewed Original ResearchConceptsIGF-1 levelsInsulin-like growth factor-1Growth factor-1Fat-free massFramingham Heart StudyMass indexInterleukin-6TNF-alphaHeart StudyHigh serum interleukin-6 levelsHigher serum IGF-1 levelsBlood mononuclear cell productionOlder community-dwelling menSerum IGF-1 levelsSerum interleukin-6 levelsCommunity-dwelling older personsFat-free mass indexCommunity-dwelling elderly adultsSerum interleukin-6Interleukin-6 levelsCommunity-dwelling menMononuclear cell productionBody mass indexCytokines TNF-alphaFactor 1Mitral Annular Calcification Predicts Cardiovascular Morbidity and Mortality
Fox C, Vasan R, Parise H, Levy D, O’Donnell C, D’Agostino R, Benjamin E. Mitral Annular Calcification Predicts Cardiovascular Morbidity and Mortality. Circulation 2003, 107: 1492-1496. PMID: 12654605, DOI: 10.1161/01.cir.0000058168.26163.bc.Peer-Reviewed Original ResearchConceptsMitral annular calcificationIncident CVDCVD deathCause deathAnnular calcificationHazard ratioPresence of MACIncident CVD eventsIncidence of CVDCardiovascular disease outcomesFramingham Heart Study subjectsMultivariable adjusted analysesSmall retrospective studiesCommunity-based cohortM-mode echocardiographyProportional hazards modelCardiovascular morbidityCVD eventsCVD morbidityCVD riskEchocardiographic assessmentAdjusted analysisRetrospective studyProspective dataIndependent association