2022
Coronary Orbital Atherectomy in Patients With Severe Aortic Stenosis.
Donatelle M, Agasthi P, Parise H, Igyarto Z, Martinsen B, Leon M, Beohar N. Coronary Orbital Atherectomy in Patients With Severe Aortic Stenosis. Journal Of Invasive Cardiology 2022, 34: e696-e700. PMID: 36200995, DOI: 10.25270/jic/22.00066.Peer-Reviewed Original ResearchConceptsSevere aortic stenosisNon-AS cohortAortic stenosisNon-AS patientsSuccessful stent placementOrbital atherectomyStent placementOA useHospital major adverse cardiovascular eventsSevere calcific coronary artery diseaseCalcific coronary artery diseaseConcomitant severe aortic stenosisMajor adverse cardiovascular eventsCoronary orbital atherectomyIdeal revascularization strategyAdverse cardiovascular eventsMount Sinai Medical CenterProspective randomized trialsGlomerular filtration rateCoronary artery diseaseSinai Medical CenterPaucity of dataAngiographic complicationsMACE rateCardiovascular eventsCoronary orbital atherectomy treatment of Hispanic and Latino patients: A real‐world comparative analysis
Beohar N, Stone G, Martinsen B, Parise H, Vinardell J, Heimowitz T, Koelbl C, Leon M, Kirtane A. Coronary orbital atherectomy treatment of Hispanic and Latino patients: A real‐world comparative analysis. Catheterization And Cardiovascular Interventions 2022, 99: 1752-1757. PMID: 35312163, PMCID: PMC9540752, DOI: 10.1002/ccd.30158.Peer-Reviewed Original ResearchConceptsMajor adverse cardiac eventsNon-HL groupNon-HL patientsHL patientsLatino patientsHigh prevalenceRetrospective analysisHL groupLargest real-world experienceReal-world comparative analysesCoronary artery calcium scoreOrbital atherectomy treatmentAdverse cardiac eventsArtery calcium scoreMount Sinai Medical CenterPercutaneous coronary interventionCardiovascular disease mortalityHigh-risk populationOverall mean ageSinai Medical CenterClinical trial researchElectronic health recordsAngiographic complicationsAtherectomy useOA use
2016
Polymer-Free Biolimus A9-Coated Stents in the Treatment of De Novo Coronary Lesions 4- and 12-Month Angiographic Follow-Up and Final 5-Year Clinical Outcomes of the Prospective, Multicenter BioFreedom FIM Clinical Trial
Costa R, Abizaid A, Mehran R, Schofer J, Schuler G, Hauptmann K, Magalhães M, Parise H, Grube E, Investigators B. Polymer-Free Biolimus A9-Coated Stents in the Treatment of De Novo Coronary Lesions 4- and 12-Month Angiographic Follow-Up and Final 5-Year Clinical Outcomes of the Prospective, Multicenter BioFreedom FIM Clinical Trial. JACC Cardiovascular Interventions 2016, 9: 51-64. PMID: 26762911, DOI: 10.1016/j.jcin.2015.09.008.Peer-Reviewed Original ResearchMeSH KeywordsAgedCardiovascular AgentsCoronary AngiographyCoronary Artery DiseaseCoronary VesselsDrug-Eluting StentsFemaleGermanyHumansKaplan-Meier EstimateMaleMiddle AgedNeointimaPaclitaxelPercutaneous Coronary InterventionPredictive Value of TestsProspective StudiesProsthesis DesignRisk FactorsSingle-Blind MethodSirolimusStainless SteelSurface PropertiesTime FactorsTreatment OutcomeConceptsStent late lumen lossPaclitaxel-eluting stentsLate lumen lossDrug-coated stentsStent thrombosisBiolimus A9First-generation paclitaxel-eluting stentsDe novo coronary lesionsMajor adverse cardiac eventsPolymer-free biolimus A9Probable stent thrombosisAdverse cardiac eventsNovo coronary lesionsTarget lesion revascularizationClinical event ratesLong-term outcomesLesion revascularizationAngiographic followCardiac eventsClinical outcomesCoronary lesionsLesions 4Lumen lossStandard doseStainless steel platform
2014
Clinical and Angiographic Evaluation of the Resolute Zotarolimus-Eluting Coronary Stent in Japanese Patients
Saito S, Maehara A, Vlachojannis G, Parise H, Mehran R. Clinical and Angiographic Evaluation of the Resolute Zotarolimus-Eluting Coronary Stent in Japanese Patients. Circulation Journal 2014, 79: 96. PMID: 25428602, DOI: 10.1253/circj.cj-14-0836.Peer-Reviewed Original ResearchMeSH KeywordsCombined Modality TherapyCoronary AngiographyCoronary RestenosisCoronary StenosisDrug-Eluting StentsHeart DiseasesHumansIncidenceJapanMyocardial InfarctionMyocardial RevascularizationNeointimaPlatelet Aggregation InhibitorsPostoperative ComplicationsProspective StudiesRisk FactorsSirolimusTreatment OutcomeUltrasonography, InterventionalConceptsTarget lesion revascularizationJapanese patientsR-ZESDe novo native coronary lesionsIncidence of TLRSingle-arm observational studyStent late lumen lossLong-term clinical outcomesNative coronary lesionsTarget lesion failureLate lumen lossLesion revascularizationResolute ZotarolimusLesion failureVolume obstructionAngiographic evaluationClinical outcomesCoronary lesionsLumen lossObservational studyNeointimal hyperplasiaIntravascular ultrasoundPatientsVessel studiesCoronary stentsImpact of Coronary Lesion Complexity on Drug-Eluting Stent Outcomes in Patients With and Without Diabetes Mellitus Analysis From 18 Pooled Randomized Trials
Kedhi E, Généreux P, Palmerini T, McAndrew T, Parise H, Mehran R, Dangas G, Stone G. Impact of Coronary Lesion Complexity on Drug-Eluting Stent Outcomes in Patients With and Without Diabetes Mellitus Analysis From 18 Pooled Randomized Trials. Journal Of The American College Of Cardiology 2014, 63: 2111-2118. PMID: 24632279, DOI: 10.1016/j.jacc.2014.01.064.Peer-Reviewed Original ResearchConceptsDiabetes mellitusRepeat revascularizationMyocardial infarctionLesion complexityStent outcomesCardiac deathType A/B1 lesionsType B2/C lesionsB2/C lesionsPropensity score-matched groupsCoronary lesion complexityTarget vessel revascularizationPatient-level dataB1 lesionsNoncomplex lesionsVessel revascularizationDiabetic statusC lesionsDES eraRandomized trialsRisk factorsTarget lesionsDES safetyTreatment outcomesBaseline differences
2013
Comparative effectiveness of upstream glycoprotein IIb/IIIa inhibitors in patients with moderate- and high-risk acute coronary syndromes: An Acute Catheterization and Urgent Intervention Triage Strategy (ACUITY) substudy
Nazif T, Mehran R, Lee E, Fahy M, Parise H, Stone G, Kirtane A. Comparative effectiveness of upstream glycoprotein IIb/IIIa inhibitors in patients with moderate- and high-risk acute coronary syndromes: An Acute Catheterization and Urgent Intervention Triage Strategy (ACUITY) substudy. American Heart Journal 2013, 167: 43-50. PMID: 24332141, DOI: 10.1016/j.ahj.2013.10.013.Peer-Reviewed Original ResearchConceptsGlycoprotein IIb/IIIa receptor inhibitorsNet adverse clinical eventsMajor adverse cardiac eventsHigh-risk acute coronary syndromesAcute coronary syndromeMajor bleedingCoronary syndromeComposite major adverse cardiac eventsIIb/IIIa receptor inhibitorsGlycoprotein IIb/IIIa inhibitorsEarly invasive management strategyIIb/IIIa inhibitorsInvasive management strategySafety of tirofibanAdverse cardiac eventsSimilar clinical outcomesAdverse clinical eventsUse of tirofibanComparative effectiveness analysisSignificant differencesACUITY trialAcute CatheterizationUpstream tirofibanMultivariable adjustmentUpstream therapyRelationship between ST-segment resolution and anterior infarct size after primary percutaneous coronary intervention: analysis from the INFUSE-AMI trial
Dizon J, Brener S, Maehara A, Witzenbichler B, Biviano A, Godlewski J, Parise H, Dambrink J, Mehran R, Gibson C, Stone G. Relationship between ST-segment resolution and anterior infarct size after primary percutaneous coronary intervention: analysis from the INFUSE-AMI trial. European Heart Journal Acute Cardiovascular Care 2013, 3: 78-83. PMID: 24562806, PMCID: PMC3932776, DOI: 10.1177/2048872613508658.Peer-Reviewed Original ResearchMeSH KeywordsAbciximabAnterior Wall Myocardial InfarctionAntibodies, MonoclonalCoronary AngiographyElectrocardiographyFemaleHeart VentriclesHumansImmunoglobulin Fab FragmentsInfusions, IntravenousMagnetic Resonance Imaging, CineMaleMiddle AgedPercutaneous Coronary InterventionPlatelet Aggregation InhibitorsPlatelet Glycoprotein GPIIb-IIIa ComplexTreatment OutcomeConceptsST-segment elevation myocardial infarctionST-segment resolutionST-segment elevationAnterior ST-segment elevation myocardial infarctionResidual ST-segment elevationDays post interventionINFUSE-AMI trialMin post interventionInfarct sizeMicrovascular obstructionPost interventionInfarct massBaseline ST-segment elevationPrimary percutaneous coronary interventionSimple ECG parametersUltimate infarct sizeElevation myocardial infarctionPercutaneous coronary interventionInfarct-related leadsTotal LV massQ wave changesSignificant Q wavesECG methodSingle leadBolus abciximabRelationship Between Myocardial Reperfusion, Infarct Size, and Mortality The INFUSE-AMI (Intracoronary Abciximab and Aspiration Thrombectomy in Patients With Large Anterior Myocardial Infarction) Trial
Brener S, Maehara A, Dizon J, Fahy M, Witzenbichler B, Parise H, El-Omar M, Dambrink J, Mehran R, Oldroyd K, Gibson C, Stone G. Relationship Between Myocardial Reperfusion, Infarct Size, and Mortality The INFUSE-AMI (Intracoronary Abciximab and Aspiration Thrombectomy in Patients With Large Anterior Myocardial Infarction) Trial. JACC Cardiovascular Interventions 2013, 6: 718-724. PMID: 23866184, DOI: 10.1016/j.jcin.2013.03.013.Peer-Reviewed Original ResearchMeSH KeywordsAbciximabAgedAnterior Wall Myocardial InfarctionAntibodies, MonoclonalAnticoagulantsChi-Square DistributionCoronary AngiographyCoronary CirculationFemaleHumansImmunoglobulin Fab FragmentsMagnetic Resonance Imaging, CineMaleMicrocirculationMiddle AgedMyocardiumPercutaneous Coronary InterventionRecovery of FunctionRisk FactorsSuctionThrombectomyTime FactorsTreatment OutcomeConceptsINFUSE-AMI trialST-segment elevation myocardial infarctionElevation myocardial infarctionMBG 2/3Infarct sizeMicrocirculatory reperfusionMicrovascular obstructionEjection fractionMyocardial infarctionAnterior ST-segment elevation myocardial infarctionST-segment elevation myocardial infarction (STEMI) patientsElevation myocardial infarction patientsPrimary percutaneous coronary interventionManual thrombus aspirationPercutaneous coronary interventionSmaller infarct sizeMyocardial infarction patientsRate of deathBolus abciximabIntracoronary abciximabMBG 0/1Primary endpointCoronary interventionThrombus aspirationMyocardial reperfusionImpact of Scheduled Angiographic Follow‐Up in Patients Treated With Primary Percutaneous Coronary Intervention for ST‐Segment Elevation Myocardial Infarction
MINDRESCU C, BRENER S, GUERCHICOFF A, FAHY M, PARISE H, MEHRAN R, STONE G. Impact of Scheduled Angiographic Follow‐Up in Patients Treated With Primary Percutaneous Coronary Intervention for ST‐Segment Elevation Myocardial Infarction. Journal Of Interventional Cardiology 2013, 26: 319-324. PMID: 23795656, DOI: 10.1111/joic.12038.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionTarget vessel revascularizationPercutaneous coronary interventionPrimary percutaneous coronary interventionElevation myocardial infarctionMyocardial infarctionCoronary interventionStent thrombosisAcute Myocardial Infarction trialMyocardial Infarction trialOutcomes of patientsRate of revascularizationAngiographic Follow-upSAF groupRate of deathHarmonizing OutcomesVessel revascularizationCerebral eventsMI ratesFollow-upPatientsRevascularizationInfarctionComposite rateDeathImpact of Bivalirudin and Paclitaxel-Eluting Stents on Outcomes in Patients Undergoing Primary Percutaneous Coronary Intervention of the Left Anterior Descending Artery
Wöhrle J, Brodie B, Witzenbichler B, Dudek D, Kornowski R, Metzger C, Grines C, McAndrew T, Parise H, Sergie Z, Mehran R, Stone G. Impact of Bivalirudin and Paclitaxel-Eluting Stents on Outcomes in Patients Undergoing Primary Percutaneous Coronary Intervention of the Left Anterior Descending Artery. The American Journal Of Cardiology 2013, 112: 753-760. PMID: 23746479, DOI: 10.1016/j.amjcard.2013.05.006.Peer-Reviewed Original ResearchMeSH KeywordsAgedAntineoplastic Agents, PhytogenicAntithrombinsCoronary AngiographyCoronary VesselsDrug-Eluting StentsElectrocardiographyFemaleFollow-Up StudiesHirudinsHumansMaleMiddle AgedMyocardial InfarctionPaclitaxelPeptide FragmentsPercutaneous Coronary InterventionProspective StudiesRecombinant ProteinsTreatment OutcomeConceptsPrimary percutaneous coronary interventionST-elevation myocardial infarctionPaclitaxel-eluting stentingImpact of bivalirudinTarget vessel revascularizationPercutaneous coronary interventionVessel revascularizationCoronary interventionCardiac deathPrimary PCIGlycoprotein IIb/IIIa inhibitorsIschemia-driven target vessel revascularizationIIb/IIIa inhibitorsLeft anterior descending (LAD) arteryHORIZONS-AMI trialMajor bleeding eventsUse of bivalirudinAnterior descending (LAD) arteryElevation myocardial infarctionBare-metal stentingSignificant lower rateLower ratesBleeding eventsCardiovascular eventsRevascularization ratesInfarct size and mortality in patients with proximal versus mid left anterior descending artery occlusion: The Intracoronary Abciximab and Aspiration Thrombectomy in Patients With Large Anterior Myocardial Infarction (INFUSE-AMI) trial
Brener S, Witzenbichler B, Maehara A, Dizon J, Fahy M, El-Omar M, Dambrink J, Genereux P, Mehran R, Oldroyd K, Parise H, Gibson C, Stone G. Infarct size and mortality in patients with proximal versus mid left anterior descending artery occlusion: The Intracoronary Abciximab and Aspiration Thrombectomy in Patients With Large Anterior Myocardial Infarction (INFUSE-AMI) trial. American Heart Journal 2013, 166: 64-70. PMID: 23816023, DOI: 10.1016/j.ahj.2013.03.029.Peer-Reviewed Original ResearchMeSH KeywordsAbciximabAgedAntibodies, MonoclonalCardiac CatheterizationCoronary AngiographyCoronary StenosisCoronary VesselsElectrocardiographyFemaleHumansImmunoglobulin Fab FragmentsInjections, Intra-ArterialMagnetic Resonance Imaging, CineMaleMiddle AgedMyocardial InfarctionPlatelet Aggregation InhibitorsPlatelet Glycoprotein GPIIb-IIIa ComplexSurvival RateThrombectomyTreatment OutcomeUnited StatesConceptsST-segment elevation myocardial infarctionElevation myocardial infarctionInfarct sizeMyocardial infarctionAnterior ST-segment elevation myocardial infarctionMyocardial blush grade 2/3Myocardial infarction flow 3Primary percutaneous coronary interventionINFUSE-AMI trialMyocardial Infarction trialPrimary end pointST-segment resolutionPercutaneous coronary interventionSeptal perforator branchExtent of myocardiumEffect of ICSBivalirudin anticoagulationBolus abciximabFinal ThrombolysisIntracoronary abciximabKillip classLAD infarctsReperfusion therapyArtery occlusionCoronary intervention
2011
Impact of Diabetes Mellitus on the Safety and Effectiveness of Bivalirudin in Patients With Acute Myocardial Infarction Undergoing Primary Angioplasty Analysis From the HORIZONS-AMI (Harmonizing Outcomes with RevasculariZatiON and Stents in Acute Myocardial Infarction) Trial
Witzenbichler B, Mehran R, Guagliumi G, Dudek D, Huber K, Kornowski R, Stuckey T, Fahy M, Parise H, Stone G. Impact of Diabetes Mellitus on the Safety and Effectiveness of Bivalirudin in Patients With Acute Myocardial Infarction Undergoing Primary Angioplasty Analysis From the HORIZONS-AMI (Harmonizing Outcomes with RevasculariZatiON and Stents in Acute Myocardial Infarction) Trial. JACC Cardiovascular Interventions 2011, 4: 760-768. PMID: 21777884, DOI: 10.1016/j.jcin.2011.04.008.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngioplasty, Balloon, CoronaryAntithrombinsCoronary AngiographyDiabetes MellitusDose-Response Relationship, DrugDouble-Blind MethodElectrocardiographyFemaleFollow-Up StudiesHirudinsHumansHypoglycemic AgentsMaleMiddle AgedMyocardial InfarctionPeptide FragmentsProspective StudiesRecombinant ProteinsStentsSurvival RateTime FactorsTreatment OutcomeConceptsGlycoprotein IIb/IIIa inhibitorsST-segment elevation myocardial infarctionPrimary percutaneous coronary interventionHORIZONS-AMI trialDiabetes mellitusDiabetic patientsMyocardial infarctionPrimary PCIMajor adverse cardiac eventsIIb/IIIa inhibitorsEffectiveness of bivalirudinEfficacy of bivalirudinAdverse cardiac eventsAcute coronary syndromeElevation myocardial infarctionPercutaneous coronary interventionAcute myocardial infarctionMajor bleedingCardiac mortalityCoronary syndromeAnticoagulant therapyCardiac eventsCoronary interventionCardiac deathUnfractionated heparinMeta-Analysis of Randomized Studies Comparing Intravascular Ultrasound Versus Angiographic Guidance of Percutaneous Coronary Intervention in Pre–Drug-Eluting Stent Era
Parise H, Maehara A, Stone G, Leon M, Mintz G. Meta-Analysis of Randomized Studies Comparing Intravascular Ultrasound Versus Angiographic Guidance of Percutaneous Coronary Intervention in Pre–Drug-Eluting Stent Era. The American Journal Of Cardiology 2011, 107: 374-382. PMID: 21257001, DOI: 10.1016/j.amjcard.2010.09.030.Peer-Reviewed Original ResearchConceptsBare metal stent implantationMetal stent implantationMajor adverse cardiac eventsAdverse cardiac eventsPercutaneous coronary interventionIVUS guidanceStent implantationAngiographic restenosisCardiac eventsCoronary interventionMyocardial infarctionIntravascular ultrasoundOverall major adverse cardiac eventsSingle-center studyAcute procedural resultsMinimum lumen diameterRevascularization ratesStent eraBalloon angioplastyProcedural resultsStent studiesAngiographic guidanceNoninferiority trialMeta-AnalysisLumen diameter
2010
Impact of Transfer for Primary Percutaneous Coronary Intervention on Survival and Clinical Outcomes (from the HORIZONS-AMI Trial)
Wöhrle J, Desaga M, Metzger C, Huber K, Suryapranata H, Guetta V, Guagliumi G, Witzenbichler B, Parise H, Mehran R, Stone G. Impact of Transfer for Primary Percutaneous Coronary Intervention on Survival and Clinical Outcomes (from the HORIZONS-AMI Trial). The American Journal Of Cardiology 2010, 106: 1218-1224. PMID: 21029816, DOI: 10.1016/j.amjcard.2010.06.049.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngioplasty, Balloon, CoronaryAnticoagulantsChi-Square DistributionCoronary AngiographyFemaleHeparinHirudinsHumansMaleMiddle AgedMyocardial InfarctionPatient TransferPeptide FragmentsProportional Hazards ModelsProspective StudiesRecombinant ProteinsStatistics, NonparametricSurvival RateTime FactorsTreatment OutcomeConceptsPrimary percutaneous coronary interventionPrimary PCIST-segment elevation myocardial infarctionHORIZONS-AMI trialPercutaneous coronary interventionClinical outcomesCoronary interventionGlycoprotein IIb/IIIa inhibitorsMajor adverse cardiac eventsNet adverse clinical eventsIIb/IIIa inhibitorsAdverse cardiac eventsAdverse clinical eventsElevation myocardial infarctionPreferred reperfusion strategyPresentation of patientsInterventional hospitalMajor bleedingReperfusion strategyBalloon timeCardiac eventsCardiac deathPCI centerUnfractionated heparinMedian time