2024
Effect of Alcohol-Mediated Renal Denervation on Blood Pressure in the Presence of Antihypertensive Medications: Primary Results From the TARGET BP I Randomized Clinical Trial
Kandzari D, Weber M, Pathak A, Zidar J, Saxena M, David S, Schmieder R, Janas A, Langer C, Persu A, Mendelsohn F, Ameloot K, Foster M, Fischell T, Parise H, Mahfoud F. Effect of Alcohol-Mediated Renal Denervation on Blood Pressure in the Presence of Antihypertensive Medications: Primary Results From the TARGET BP I Randomized Clinical Trial. Circulation 2024, 149: 1875-1884. PMID: 38587557, DOI: 10.1161/circulationaha.124.069291.Peer-Reviewed Original ResearchSystolic blood pressureOffice systolic blood pressureRenal denervationOffice diastolic BPAmbulatory systolic BPBlood pressureSham controlsPrimary endpointBetween-group differencesNo significant differenceAntihypertensive medicationsDiastolic BPSystolic BPPresence of antihypertensive medicationBaseline-adjusted changeRenal artery dissectionMonths post-procedureSignificant differenceRenal denervation groupAmbulatory systolic blood pressureNo significant between-group differencesStatistically significant reductionSignificant between-group differencesSecondary endpointsOffice BP
2018
CHEMICAL RENAL DENERVATION WITH ALCOHOL – LONG TERM RESULTS FROM THE PEREGRINE POST-MARKET STUDY
Persu A, Renkin J, Hochul M, Wojakowski W, Böhm M, Mahfoud F, Schmieder R, van der Giet M, de Bucourt M, Zirlik A, Neuzil P, Haratani N, Parise H, Fischell T, Bertog S, Sievert K, Sievert H. CHEMICAL RENAL DENERVATION WITH ALCOHOL – LONG TERM RESULTS FROM THE PEREGRINE POST-MARKET STUDY. Journal Of Hypertension 2018, 36: e123. DOI: 10.1097/01.hjh.0000539319.18701.45.Peer-Reviewed Original ResearchSystolic office blood pressureChemical renal denervationResistant hypertensionPost-market studyRenal denervationVascular access site complicationsWhite-coat resistant hypertensionMajor efficacy endpointsMulticenter European trialSignificant BP reductionOffice blood pressureRenal artery dissectionTransient ischemic attackAccess site complicationsAnti-hypertensive medicationsMean procedure timeMajor safety endpointsML of alcoholAnatomical eligibilityAntihypertensive medicationsBP reductionEligible patientsIschemic attackOpen labelRenal events