2023
National Trends in Racial and Ethnic Disparities in Use of Recommended Therapies in Adults with Atherosclerotic Cardiovascular Disease, 1999-2020
Lu Y, Liu Y, Dhingra L, Caraballo C, Mahajan S, Massey D, Spatz E, Sharma R, Rodriguez F, Watson K, Masoudi F, Krumholz H. National Trends in Racial and Ethnic Disparities in Use of Recommended Therapies in Adults with Atherosclerotic Cardiovascular Disease, 1999-2020. JAMA Network Open 2023, 6: e2345964. PMID: 38039001, PMCID: PMC10692850, DOI: 10.1001/jamanetworkopen.2023.45964.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAngiotensin Receptor AntagonistsAngiotensin-Converting Enzyme InhibitorsCardiovascular DiseasesCross-Sectional StudiesFemaleHumansNutrition SurveysConceptsAtherosclerotic cardiovascular diseaseHistory of ASCVDCross-sectional studyLifestyle modificationPharmacological medicationsOptimal careCurrent careUS adultsEthnic differencesWhite individualsGuideline-recommended therapiesTotal cholesterol controlNon-Hispanic white individualsNutrition Examination SurveyLatino individualsQuality of careSelf-reported raceStatin useRecommended TherapiesSecondary preventionCholesterol controlOptimal regimensSmoking cessationEligible participantsExamination Survey
2022
Analysis of Dual Combination Therapies Used in Treatment of Hypertension in a Multinational Cohort
Lu Y, Van Zandt M, Liu Y, Li J, Wang X, Chen Y, Chen Z, Cho J, Dorajoo SR, Feng M, Hsu MH, Hsu JC, Iqbal U, Jonnagaddala J, Li YC, Liaw ST, Lim HS, Ngiam KY, Nguyen PA, Park RW, Pratt N, Reich C, Rhee SY, Sathappan SMK, Shin SJ, Tan HX, You SC, Zhang X, Krumholz HM, Suchard MA, Xu H. Analysis of Dual Combination Therapies Used in Treatment of Hypertension in a Multinational Cohort. JAMA Network Open 2022, 5: e223877. PMID: 35323951, PMCID: PMC8948532, DOI: 10.1001/jamanetworkopen.2022.3877.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdrenergic beta-AntagonistsAdultAgedAngiotensin Receptor AntagonistsAngiotensin-Converting Enzyme InhibitorsAntihypertensive AgentsAustraliaCalcium Channel BlockersCohort StudiesFemaleHumansHypertensionMaleMiddle AgedThiazidesYoung AdultConceptsDual combination therapyUse of ACEIAntihypertensive drug classesProportion of patientsKhoo Teck Puat HospitalCombination therapyUniversity Hospital databaseHospital databaseDrug classesDual combinationSouth Western Sydney Local Health DistrictWestern Sydney Local Health DistrictPatients age 65 yearsSydney Local Health DistrictElectronic health record databasePatients age 18Local Health DistrictAge 65 yearsTreatment of hypertensionHealth record databaseARB monotherapyTreatment escalationAdult patientsCohort studyCombination regimen
2021
Comparative First-Line Effectiveness and Safety of ACE (Angiotensin-Converting Enzyme) Inhibitors and Angiotensin Receptor Blockers
Chen R, Suchard MA, Krumholz HM, Schuemie MJ, Shea S, Duke J, Pratt N, Reich CG, Madigan D, You SC, Ryan PB, Hripcsak G. Comparative First-Line Effectiveness and Safety of ACE (Angiotensin-Converting Enzyme) Inhibitors and Angiotensin Receptor Blockers. Hypertension 2021, 78: 591-603. PMID: 34304580, PMCID: PMC8363588, DOI: 10.1161/hypertensionaha.120.16667.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAngiotensin Receptor AntagonistsAngiotensin-Converting Enzyme InhibitorsAntihypertensive AgentsChildChild, PreschoolFemaleHumansHypertensionInfantMaleMiddle AgedRetrospective StudiesTreatment OutcomeYoung AdultAssociation of Angiotensin‐Converting Enzyme Inhibitors and Angiotensin Receptor Blockers with the Risk of Hospitalization and Death in Hypertensive Patients with Coronavirus Disease‐19
Khera R, Clark C, Lu Y, Guo Y, Ren S, Truax B, Spatz ES, Murugiah K, Lin Z, Omer SB, Vojta D, Krumholz HM. Association of Angiotensin‐Converting Enzyme Inhibitors and Angiotensin Receptor Blockers with the Risk of Hospitalization and Death in Hypertensive Patients with Coronavirus Disease‐19. Journal Of The American Heart Association 2021, 10: e018086. PMID: 33624516, PMCID: PMC8403305, DOI: 10.1161/jaha.120.018086.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAngiotensin Receptor AntagonistsAngiotensin-Converting Enzyme InhibitorsCohort StudiesCOVID-19FemaleHospital MortalityHospitalizationHumansHypertensionMaleMiddle AgedPropensity ScoreYoung AdultConceptsAngiotensin receptor blockersLower hospitalization riskACE inhibitorsCOVID-19 hospitalizationHospitalization riskHospital mortalityReceptor blockersValidation cohortAcute respiratory syndrome coronavirus 2 infectionSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infectionEnzyme inhibitorsSyndrome coronavirus 2 infectionAngiotensin converting enzyme (ACE) inhibitorsCoronavirus 2 infectionRisk of hospitalizationCoronavirus disease-19SARS-CoV-2COVID-19 preventionHypertensive patientsInpatient cohortOutpatient cohortContemporary cohortStudy cohortOutpatient studyMedicare group
2019
Comprehensive comparative effectiveness and safety of first-line antihypertensive drug classes: a systematic, multinational, large-scale analysis
Suchard MA, Schuemie MJ, Krumholz HM, You SC, Chen R, Pratt N, Reich CG, Duke J, Madigan D, Hripcsak G, Ryan PB. Comprehensive comparative effectiveness and safety of first-line antihypertensive drug classes: a systematic, multinational, large-scale analysis. The Lancet 2019, 394: 1816-1826. PMID: 31668726, PMCID: PMC6924620, DOI: 10.1016/s0140-6736(19)32317-7.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAngiotensin Receptor AntagonistsAngiotensin-Converting Enzyme InhibitorsAntihypertensive AgentsCalcium Channel BlockersChildCohort StudiesComparative Effectiveness ResearchDatabases, FactualDiureticsEvidence-Based MedicineFemaleHeart FailureHumansHypertensionMaleMiddle AgedMyocardial InfarctionStrokeYoung AdultConceptsNon-dihydropyridine calcium channel blockersCalcium channel blockersThiazide-like diureticsChannel blockersEnzyme inhibitorsDrug classesHazard ratioCurrent guidelinesFirst-line antihypertensive drug classesComparative effectivenessFirst-line drug classesNew-user cohort designDihydropyridine calcium channel blockerElectronic health record databaseFirst-line classesAngiotensin receptor blockersAntihypertensive drug classesAcute myocardial infarctionHealth record databaseReal-world evidenceMedical Research CouncilMillions of patientsAustralian National HealthOptimal monotherapyReceptor blockers
2015
Patterns of Use of Angiotensin‐Converting Enzyme Inhibitors/Angiotensin Receptor Blockers Among Patients With Acute Myocardial Infarction in China From 2001 to 2011: China PEACE‐Retrospective AMI Study
Liu J, Masoudi FA, Spertus JA, Wang Q, Murugiah K, Spatz ES, Li J, Li X, Ross JS, Krumholz HM, Jiang L, Group C. Patterns of Use of Angiotensin‐Converting Enzyme Inhibitors/Angiotensin Receptor Blockers Among Patients With Acute Myocardial Infarction in China From 2001 to 2011: China PEACE‐Retrospective AMI Study. Journal Of The American Heart Association 2015, 4: e001343. PMID: 25713293, PMCID: PMC4345866, DOI: 10.1161/jaha.114.001343.Peer-Reviewed Original ResearchMeSH KeywordsAcute DiseaseAngiotensin II Type 1 Receptor BlockersAngiotensin-Converting Enzyme InhibitorsChinaFemaleHospitalizationHumansMaleMiddle AgedMyocardial InfarctionRetrospective StudiesTime FactorsTreatment OutcomeConceptsACEI/ARB therapyAcute myocardial infarctionClass I indicationsARB therapyMyocardial infarctionMortality riskReceptor blockersAngiotensin-Converting Enzyme Inhibitors/Angiotensin Receptor BlockersEnzyme inhibitors/angiotensin receptor blockersChina PEACE-Retrospective AMI StudyChinese AMI patientsClass IIa recommendationRates of therapyAbsence of contraindicationsAngiotensin receptor blockersHigher mortality riskCost-effective therapyIIa recommendationAMI patientsChina PatientRetrospective studyHigh riskPatterns of useChinese guidelinesPatients
2010
Who is missing from the measures? Trends in the proportion and treatment of patients potentially excluded from publicly reported quality measures
Bernheim SM, Wang Y, Bradley EH, Masoudi FA, Rathore SS, Ross JS, Drye E, Krumholz HM. Who is missing from the measures? Trends in the proportion and treatment of patients potentially excluded from publicly reported quality measures. American Heart Journal 2010, 160: 943-950.e5. PMID: 21095284, PMCID: PMC3319386, DOI: 10.1016/j.ahj.2010.06.046.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAgedAngiotensin-Converting Enzyme InhibitorsCross-Sectional StudiesFemaleHospitalizationHumansMaleMedicaidMedicareMyocardial InfarctionOutcome and Process Assessment, Health CarePlatelet Aggregation InhibitorsPrognosisQuality ImprovementQuality Indicators, Health CareRetrospective StudiesUnited StatesConceptsAcute myocardial infarctionProportion of patientsRelative contraindicationAngiotensin-converting enzyme inhibitorTreatment of patientsMedicaid Services core measuresQuality improvement projectPublic reportingCross-sectional analysisMyocardial infarctionMedicare patientsHospital careΒ-blockersAMI admissionsPatientsInsufficient evidenceEnzyme inhibitorsTreatment ratesBetter careContraindicationsMedicaid ServicesData cohortCore measuresTreatmentImprovement project
2008
Mental Disorders, Quality of Care, and Outcomes Among Older Patients Hospitalized With Heart Failure: An Analysis of the National Heart Failure Project
Rathore SS, Wang Y, Druss BG, Masoudi FA, Krumholz HM. Mental Disorders, Quality of Care, and Outcomes Among Older Patients Hospitalized With Heart Failure: An Analysis of the National Heart Failure Project. JAMA Psychiatry 2008, 65: 1402-1408. PMID: 19047527, PMCID: PMC2790277, DOI: 10.1001/archpsyc.65.12.1402.Peer-Reviewed Original ResearchConceptsMental illness diagnosisACE inhibitor prescriptionHeart failureMultivariate adjustmentQuality of careIllness diagnosisInhibitor prescriptionLVEF evaluationMental illnessNational Heart Failure ProjectAngiotensin-converting enzyme inhibitorVentricular ejection fraction assessmentUS acute care hospitalsLeft ventricular ejection fraction assessmentHeart Failure ProjectAcute care hospitalsHigher crude ratesEjection fraction assessmentPopulation-based sampleEligible patientsTreatment contraindicationsCause readmissionElderly patientsOlder patientsCare hospitalAssociation of Early Follow-up After Acute Myocardial Infarction With Higher Rates of Medication Use
Daugherty SL, Ho PM, Spertus JA, Jones PG, Bach RG, Krumholz HM, Peterson ED, Rumsfeld JS, Masoudi FA. Association of Early Follow-up After Acute Myocardial Infarction With Higher Rates of Medication Use. JAMA Internal Medicine 2008, 168: 485-491. PMID: 18332293, DOI: 10.1001/archinte.168.5.485.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAngiotensin-Converting Enzyme InhibitorsAspirinContinuity of Patient CareEvidence-Based MedicineFemaleHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMaleMiddle AgedMyocardial InfarctionPoisson DistributionProportional Hazards ModelsProspective StudiesRegistriesRegression AnalysisTreatment OutcomeConceptsAcute myocardial infarctionMedication useMyocardial infarctionMultivariable analysisEarly outpatientEvidence-based medication useProspective Registry Evaluating OutcomesSecondary analysisEarly Follow-upBeta-blocker useUse of aspirinCurrent guideline recommendationsPrimary care physiciansEvidence-based therapiesHigh rateEligible patientsStatin useClinical characteristicsHospital dischargePrimary outcomeCare physiciansGuideline recommendationsMedication prescriptionsFollow-upEvaluating Outcomes
2007
Adverse Effects of Combination Angiotensin II Receptor Blockers Plus Angiotensin-Converting Enzyme Inhibitors for Left Ventricular Dysfunction: A Quantitative Review of Data From Randomized Clinical Trials
Phillips CO, Kashani A, Ko DK, Francis G, Krumholz HM. Adverse Effects of Combination Angiotensin II Receptor Blockers Plus Angiotensin-Converting Enzyme Inhibitors for Left Ventricular Dysfunction: A Quantitative Review of Data From Randomized Clinical Trials. JAMA Internal Medicine 2007, 167: 1930-1936. PMID: 17923591, DOI: 10.1001/archinte.167.18.1930.Peer-Reviewed Original ResearchMeSH KeywordsAngiotensin Receptor AntagonistsAngiotensin-Converting Enzyme InhibitorsDrug Therapy, CombinationHumansHyperkalemiaKidney DiseasesRandomized Controlled Trials as TopicVentricular Dysfunction, LeftConceptsAngiotensin II receptor blockersSymptomatic left ventricular dysfunctionLeft ventricular dysfunctionII receptor blockersVentricular dysfunctionAdverse effectsMedication discontinuationReceptor blockersSymptomatic hypotensionRenal functionACE inhibitorsClinical trialsRelative riskEnzyme inhibitorsAngiotensin converting enzyme (ACE) inhibitorsACE inhibitor therapyHealth clinical trialsChronic heart failureRandomized clinical trialsAcute myocardial infarctionConfidence intervalsRandom-effects modelSignificant increaseEligible RCTsHeart failure
2006
Socioeconomic status, treatment, and outcomes among elderly patients hospitalized with heart failure: Findings from the National Heart Failure Project
Rathore SS, Masoudi FA, Wang Y, Curtis JP, Foody JM, Havranek EP, Krumholz HM. Socioeconomic status, treatment, and outcomes among elderly patients hospitalized with heart failure: Findings from the National Heart Failure Project. American Heart Journal 2006, 152: 371-378. PMID: 16875925, PMCID: PMC2790269, DOI: 10.1016/j.ahj.2005.12.002.Peer-Reviewed Original ResearchConceptsLeft ventricular systolic function assessmentHigh SES patientsVentricular systolic function assessmentHeart failureSES patientsSystolic function assessmentYear of dischargeQuality of careSocioeconomic statusMultivariable adjustmentFunction assessmentEnzyme inhibitorsNational Heart Failure ProjectHeart Failure ProjectPrescription of angiotensinLow SES patientsPatients' socioeconomic statusAssociation of SESYear of admissionMedical record dataHierarchical logistic regression modelsLow socioeconomic statusLogistic regression modelsPatient sElderly patientsAHA/ACC Guidelines for Secondary Prevention for Patients With Coronary and Other Atherosclerotic Vascular Disease: 2006 Update Endorsed by the National Heart, Lung, and Blood Institute
Smith S, Allen J, Blair S, Bonow R, Brass L, Fonarow G, Grundy S, Hiratzka L, Jones D, Krumholz H, Mosca L, Pasternak R, Pearson T, Pfeffer M, Taubert K. AHA/ACC Guidelines for Secondary Prevention for Patients With Coronary and Other Atherosclerotic Vascular Disease: 2006 Update Endorsed by the National Heart, Lung, and Blood Institute. Journal Of The American College Of Cardiology 2006, 47: 2130-2139. PMID: 16697342, DOI: 10.1016/j.jacc.2006.04.026.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAngiotensin II Type 1 Receptor BlockersAngiotensin-Converting Enzyme InhibitorsAtherosclerosisCardiovascular AgentsCoronary Artery DiseaseDiabetes MellitusDyslipidemiasHealth BehaviorHematologic AgentsHumansHypertensionHypolipidemic AgentsInfluenza VaccinesMineralocorticoid Receptor AntagonistsMotor ActivityObesitySmoking Cessation
2005
Sex, quality of care, and outcomes of elderly patients hospitalized with heart failure: Findings from the National Heart Failure Project
Rathore SS, Foody JM, Wang Y, Herrin J, Masoudi FA, Havranek EP, Ordin DL, Krumholz HM. Sex, quality of care, and outcomes of elderly patients hospitalized with heart failure: Findings from the National Heart Failure Project. American Heart Journal 2005, 149: 121-128. PMID: 15660043, PMCID: PMC2790278, DOI: 10.1016/j.ahj.2004.06.008.Peer-Reviewed Original ResearchConceptsAngiotensin receptor blockersNational Heart Failure ProjectLeft ventricular systolic functionQuality of careACE inhibitor prescriptionHeart Failure ProjectService Medicare patientsHeart failureInhibitor prescriptionMedicare patientsMultivariable hierarchical logistic regression modelsLower crude ratesPrescription of angiotensinLeft ventricular dysfunctionVentricular systolic functionYear of admissionHierarchical logistic regression modelsLower mortality rateLogistic regression modelsSex differencesLow overall rateMultivariable adjustmentVentricular dysfunctionElderly patientsReceptor blockers
2004
National Patterns of Use and Effectiveness of Angiotensin-Converting Enzyme Inhibitors in Older Patients With Heart Failure and Left Ventricular Systolic Dysfunction
Masoudi FA, Rathore SS, Wang Y, Havranek EP, Curtis JP, Foody JM, Krumholz HM. National Patterns of Use and Effectiveness of Angiotensin-Converting Enzyme Inhibitors in Older Patients With Heart Failure and Left Ventricular Systolic Dysfunction. Circulation 2004, 110: 724-731. PMID: 15289383, DOI: 10.1161/01.cir.0000138934.28340.ed.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAngiotensin-Converting Enzyme InhibitorsCohort StudiesComorbidityCreatinineDrug PrescriptionsDrug UtilizationFemaleHeart FailureHumansMalePatient DischargeStroke VolumeUnited StatesVentricular Dysfunction, LeftConceptsACE inhibitor prescriptionAngiotensin receptor blockersVentricular systolic dysfunctionHeart failureACE inhibitorsInhibitor prescriptionSystolic dysfunctionOlder patientsLeft ventricular systolic dysfunctionAngiotensin converting enzyme (ACE) inhibitorsSerum creatinine levelsACE inhibitor useCreatinine levelsHospital factorsInhibitor useReceptor blockersSerum creatininePatient genderClinical trialsTherapeutic substitutionLower riskEnzyme inhibitorsLower mortalityPatientsSecondary analysisProvider and Hospital Characteristics Associated With Geographic Variation in the Evaluation and Management of Elderly Patients With Heart Failure
Havranek EP, Wolfe P, Masoudi FA, Rathore SS, Krumholz HM, Ordin DL. Provider and Hospital Characteristics Associated With Geographic Variation in the Evaluation and Management of Elderly Patients With Heart Failure. JAMA Internal Medicine 2004, 164: 1186-1191. PMID: 15197043, DOI: 10.1001/archinte.164.11.1186.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAngiotensin-Converting Enzyme InhibitorsBayes TheoremCardiac Output, LowFemaleHumansMaleMedicareMultivariate AnalysisOdds RatioPractice Patterns, Physicians'Stroke VolumeVentricular Function, LeftConceptsGuideline-based careElderly patientsHeart failureHospital characteristicsPatient factorsEnzyme inhibitorsSmall-area geographic variationLeft ventricular ejection fractionEnzyme inhibitor prescriptionHeart failure variesHeart failure careVentricular ejection fractionHospital referral regionsHigh-quality health careMedical school affiliationInhibitor prescriptionEjection fractionPatient characteristicsSmall area variationUnadjusted ratesMedicare patientsReferral regionsAppropriate prescriptionPatientsCharacteristics of providersRelationship between heart failure treatment and development of worsening renal function among hospitalized patients11Guest Editor for this manuscript was Peter M. Okin, MD, New York Hosptial-Cornell Medical Center, New York, NY.
Butler J, Forman DE, Abraham WT, Gottlieb SS, Loh E, Massie BM, O'Connor CM, Rich MW, Stevenson LW, Wang Y, Young JB, Krumholz HM. Relationship between heart failure treatment and development of worsening renal function among hospitalized patients11Guest Editor for this manuscript was Peter M. Okin, MD, New York Hosptial-Cornell Medical Center, New York, NY. American Heart Journal 2004, 147: 331-338. PMID: 14760333, DOI: 10.1016/j.ahj.2003.08.012.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnalysis of VarianceAngiotensin-Converting Enzyme InhibitorsCalcium Channel BlockersCase-Control StudiesCohort StudiesCreatinineDiureticsFemaleHeart FailureHospitalizationHumansKidney DiseasesMaleMiddle AgedRenal InsufficiencyRisk FactorsConceptsFluid intake/outputHeart failureIntake/outputRenal functionHigh riskCalcium channel blocker useHistory of HFAssociation of medicationLoop diuretic dosesPredictors of WRFElevated creatinine levelEnzyme inhibitor useHeart failure treatmentCase-control studyUse of CCBGreater fluid lossHigher hematocrit levelsUncontrolled hypertensionBlocker useDiuretic dosesCreatinine levelsInhibitor useAcute treatmentDiabetes mellitusIndependent predictors
2003
Most hospitalized older persons do not meet the enrollment criteria for clinical trials in heart failure
Masoudi FA, Havranek EP, Wolfe P, Gross CP, Rathore SS, Steiner JF, Ordin DL, Krumholz HM. Most hospitalized older persons do not meet the enrollment criteria for clinical trials in heart failure. American Heart Journal 2003, 146: 250-257. PMID: 12891192, DOI: 10.1016/s0002-8703(03)00189-3.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAge FactorsAgedAged, 80 and overAngiotensin-Converting Enzyme InhibitorsCross-Sectional StudiesFemaleHeart FailureHospitalizationHumansMaleMineralocorticoid Receptor AntagonistsPatient SelectionRandomized Controlled Trials as TopicSpironolactoneUnited StatesVentricular Dysfunction, LeftConceptsLeft ventricular systolic functionVentricular systolic functionHeart failureEnrollment criteriaClinical trialsOlder personsSystolic functionRandomized Aldactone Evaluation Study (RALES) trialHospitalized older personsRandomized Intervention TrialTrials of agentsLeft ventricular dysfunctionCongestive heart failureHeart failure patientsAcute care hospitalsCross-sectional studySubgroups of ageCommunity-based practiceTrial eligibilityVentricular dysfunctionFailure patientsOlder patientsCare hospitalMERIT-HFTrial populationAspirin, beta-blocker, and angiotensin-converting enzyme inhibitor therapy in patients with end-stage renal disease and an acute myocardial infarction
Berger AK, Duval S, Krumholz HM. Aspirin, beta-blocker, and angiotensin-converting enzyme inhibitor therapy in patients with end-stage renal disease and an acute myocardial infarction. Journal Of The American College Of Cardiology 2003, 42: 201-208. PMID: 12875751, DOI: 10.1016/s0735-1097(03)00572-2.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAgedAnalysis of VarianceAngiotensin-Converting Enzyme InhibitorsAspirinCase-Control StudiesCohort StudiesDrug Therapy, CombinationDrug UtilizationFemaleHumansKidney Failure, ChronicLogistic ModelsMaleMyocardial InfarctionPatient SelectionPeritoneal DialysisPlatelet Aggregation InhibitorsPractice Patterns, Physicians'PrognosisRenal DialysisRisk FactorsSurvival AnalysisTreatment OutcomeUnited StatesConceptsEnd-stage renal diseaseNon-ESRD patientsAcute myocardial infarctionESRD patientsRenal diseaseMyocardial infarctionAngiotensin-converting enzyme inhibitor therapyEnd-stage renal disease patientsAngiotensin-converting enzyme inhibitorStandard medical therapyEnzyme inhibitor therapyRenal disease patientsCooperative Cardiovascular Project databaseHigh-risk populationLogistic regression modelsEarly administrationInhibitor therapyMedical therapyACE inhibitorsAMI patientsPeritoneal dialysisPoor prognosisDisease patientsESRD databasePatientsNational and State Trends in Quality of Care for Acute Myocardial Infarction Between 1994-1995 and 1998-1999: The Medicare Health Care Quality Improvement Program
Burwen DR, Galusha DH, Lewis JM, Bedinger MR, Radford MJ, Krumholz HM, Foody JM. National and State Trends in Quality of Care for Acute Myocardial Infarction Between 1994-1995 and 1998-1999: The Medicare Health Care Quality Improvement Program. JAMA Internal Medicine 2003, 163: 1430-1439. PMID: 12824092, DOI: 10.1001/archinte.163.12.1430.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAgedAged, 80 and overAngioplasty, Balloon, CoronaryAngiotensin-Converting Enzyme InhibitorsAspirinFemaleHealth Care SurveysHumansMaleMedicareMiddle AgedMyocardial InfarctionPlatelet Aggregation InhibitorsQuality Indicators, Health CareQuality of Health CareSmoking CessationThrombolytic TherapyTime FactorsUnited StatesConceptsAcute myocardial infarctionQuality of careHospital arrivalEarly administrationMedian timeMyocardial infarctionPrimary percutaneous transluminal coronary angioplastyHealth Care Quality Improvement ProgramPercutaneous transluminal coronary angioplastyAcute reperfusion therapyBeta-blocker prescriptionEnzyme inhibitor prescriptionTransluminal coronary angioplastyGuideline-recommended processesQuality Improvement ProgramPopulation-based improvementsCessation counselingReperfusion therapySystolic dysfunctionInhibitor prescriptionCoronary angioplastyThrombolytic therapyMedicare patientsTherapyTime pointsRace, Quality of Care, and Outcomes of Elderly Patients Hospitalized With Heart Failure
Rathore SS, Foody JM, Wang Y, Smith GL, Herrin J, Masoudi FA, Wolfe P, Havranek EP, Ordin DL, Krumholz HM. Race, Quality of Care, and Outcomes of Elderly Patients Hospitalized With Heart Failure. JAMA 2003, 289: 2517-2524. PMID: 12759323, DOI: 10.1001/jama.289.19.2517.Peer-Reviewed Original ResearchMeSH KeywordsAgedAngiotensin-Converting Enzyme InhibitorsBlack or African AmericanFee-for-Service PlansFemaleHeart FailureHospitalsHumansMaleMedicareMultivariate AnalysisOutcome Assessment, Health CarePatient ReadmissionQuality of Health CareRetrospective StudiesSurvival AnalysisUnited StatesVentricular Function, LeftWhite PeopleConceptsLeft ventricular ejection fractionQuality of careACE inhibitor useWhite patientsBlack patientsHeart failureYear of dischargeACE inhibitorsMultivariable adjustmentInhibitor useLVEF assessmentCrude rateMedicare beneficiariesMortality rateAngiotensin receptor blocker useNational Heart Failure ProjectBlack Medicare patientsHeart Failure ProjectPrescription of angiotensinReceptor blocker useHigh rateVentricular ejection fractionYear of admissionHigher crude ratesService Medicare beneficiaries