2021
Use of Mechanical Circulatory Support Devices Among Patients With Acute Myocardial Infarction Complicated by Cardiogenic Shock
Dhruva SS, Ross JS, Mortazavi BJ, Hurley NC, Krumholz HM, Curtis JP, Berkowitz AP, Masoudi FA, Messenger JC, Parzynski CS, Ngufor CG, Girotra S, Amin AP, Shah ND, Desai NR. Use of Mechanical Circulatory Support Devices Among Patients With Acute Myocardial Infarction Complicated by Cardiogenic Shock. JAMA Network Open 2021, 4: e2037748. PMID: 33616664, PMCID: PMC7900859, DOI: 10.1001/jamanetworkopen.2020.37748.Peer-Reviewed Original ResearchMeSH KeywordsAgedAssisted CirculationCross-Sectional StudiesExtracorporeal Membrane OxygenationFemaleHeart ArrestHeart-Assist DevicesHospitals, High-VolumeHospitals, Low-VolumeHospitals, TeachingHumansIntra-Aortic Balloon PumpingMaleMiddle AgedMyocardial InfarctionPercutaneous Coronary InterventionRisk FactorsShock, CardiogenicConceptsMicroaxial left ventricular assist deviceIntra-aortic balloon pumpLeft ventricular assist devicePercutaneous coronary interventionAcute myocardial infarctionMechanical circulatory support devicesCardiogenic shockHospital-level variationSignificant hospital-level variationCirculatory support devicesMCS devicesUse of IABPDevice useMedian proportionAcute Myocardial Infarction ComplicatedCardiology-National Cardiovascular Data RegistryChest Pain-MI RegistryLimited clinical trial evidenceNational Cardiovascular Data RegistryMyocardial Infarction ComplicatedFirst medical contactSupport devicesClinical trial evidenceExtracorporeal membrane oxygenationCoronary artery stenosis
2020
Use of intravenous magnesium sulfate among patients with acute myocardial infarction in China from 2001 to 2015: China PEACE—Retrospective AMI Study
Wang X, Du X, Yang H, Bucholz E, Downing N, Spertus JA, Masoudi FA, Li J, Guan W, Gao Y, Hu S, Bai X, Krumholz HM, Li X. Use of intravenous magnesium sulfate among patients with acute myocardial infarction in China from 2001 to 2015: China PEACE—Retrospective AMI Study. BMJ Open 2020, 10: e033269. PMID: 32220910, PMCID: PMC7170603, DOI: 10.1136/bmjopen-2019-033269.Peer-Reviewed Original ResearchConceptsIntravenous magnesium sulfateAcute myocardial infarctionMagnesium sulfate useMyocardial infarctionMagnesium sulfateChina PEACE-Retrospective AMI StudyHospital-level variationProportion of hospitalsHospital-specific characteristicsMedian ORsSignificant initial decreaseReperfusion therapyCardiac arrestAMI careIneffective therapyPatient outcomesRepresentative sampleObservational studyMAIN OUTCOMEChinese guidelinesPatientsChinese hospitalsRoutine useAMI studyInfarctionAssociation of Use of an Intravascular Microaxial Left Ventricular Assist Device vs Intra-aortic Balloon Pump With In-Hospital Mortality and Major Bleeding Among Patients With Acute Myocardial Infarction Complicated by Cardiogenic Shock
Dhruva SS, Ross JS, Mortazavi BJ, Hurley NC, Krumholz HM, Curtis JP, Berkowitz A, Masoudi FA, Messenger JC, Parzynski CS, Ngufor C, Girotra S, Amin AP, Shah ND, Desai NR. Association of Use of an Intravascular Microaxial Left Ventricular Assist Device vs Intra-aortic Balloon Pump With In-Hospital Mortality and Major Bleeding Among Patients With Acute Myocardial Infarction Complicated by Cardiogenic Shock. JAMA 2020, 323: 734-745. PMID: 32040163, PMCID: PMC7042879, DOI: 10.1001/jama.2020.0254.Peer-Reviewed Original ResearchMeSH KeywordsAgedCause of DeathExtracorporeal Membrane OxygenationFemaleHeart ArrestHeart-Assist DevicesHemorrhageHospital MortalityHumansIntra-Aortic Balloon PumpingMaleMatched-Pair AnalysisMiddle AgedMyocardial InfarctionPercutaneous Coronary InterventionPropensity ScoreRegistriesRetrospective StudiesShock, CardiogenicST Elevation Myocardial InfarctionConceptsMicroaxial left ventricular assist deviceIntra-aortic balloon pumpLeft ventricular assist deviceAcute myocardial infarctionPercutaneous coronary interventionNational Cardiovascular Data RegistryCardiogenic shockHemodynamic supportMyocardial infarctionRegistry-based retrospective cohort studyCardiology-National Cardiovascular Data RegistryChest Pain-MI RegistryST-elevation myocardial infarctionMechanical circulatory support devicesGreater hemodynamic supportHospital major bleedingRetrospective cohort studyPropensity-matched pairsCirculatory support devicesVentricular assist deviceClinical laboratory dataHospital mortalityMajor bleedingHospital deathCohort study
2019
Association Between Hospital Recognition for Resuscitation Guideline Adherence and Rates of Survival for In-Hospital Cardiac Arrest
Khera R, Tang Y, Link MS, Krumholz HM, Girotra S, Chan PS. Association Between Hospital Recognition for Resuscitation Guideline Adherence and Rates of Survival for In-Hospital Cardiac Arrest. Circulation Cardiovascular Quality And Outcomes 2019, 12: e005429. PMID: 30871337, PMCID: PMC6592630, DOI: 10.1161/circoutcomes.118.005429.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAwards and PrizesFemaleGuideline AdherenceHeart ArrestHospital MortalityHospitalsHumansInpatientsMaleMiddle AgedOutcome and Process Assessment, Health CarePatient DischargePractice Guidelines as TopicPractice Patterns, Physicians'Quality Indicators, Health CareRegistriesResuscitationTime FactorsTime-to-TreatmentTreatment OutcomeUnited StatesYoung AdultConceptsHospital cardiac arrestCardiac arrestRate of survivalSpontaneous circulationIn-Hospital Cardiac ArrestGuidelines-Resuscitation registryCardiac arrest survivalEndotracheal tube placementHigh rateHospital performanceBest tertileGuidelines-ResuscitationNational GetGuideline adherenceOverall survivalBackground HospitalTube placementNational registryChest compressionsResuscitation qualityHospitalHospital recognitionAward statusSurvivalWeak association
2015
Predictors of warfarin‐associated adverse events in hospitalized patients: Opportunities to prevent patient harm
Metersky ML, Eldridge N, Wang Y, Jaser L, Bona R, Eckenrode S, Bakullari A, Andrawis M, Classen D, Krumholz HM. Predictors of warfarin‐associated adverse events in hospitalized patients: Opportunities to prevent patient harm. Journal Of Hospital Medicine 2015, 11: 276-282. PMID: 26662851, DOI: 10.1002/jhm.2528.Peer-Reviewed Original ResearchConceptsAdverse eventsWarfarin-related adverse eventsHospitalized patientsOdds ratioINR monitoringPneumonia patientsINR measurementsFrequent INR monitoringPredictors of warfarinRetrospective cohort studyAcute cardiac diseaseAcute care hospitalsFrequency of warfarinCohort studyCare hospitalSurgical patientsCardiac patientsCardiac diseasePatientsPatient harmWarfarinSignificant associationINRMore daysMonitoring System dataEffectiveness of implantable cardioverter-defibrillators in survivors of inhospital cardiac arrest
Chan PS, Krumholz HM, Spertus JA, Curtis LH, Li Y, Hammill BG, Nallamothu BK, investigators A. Effectiveness of implantable cardioverter-defibrillators in survivors of inhospital cardiac arrest. American Heart Journal 2015, 169: 870-878.e1. PMID: 26027626, PMCID: PMC4451609, DOI: 10.1016/j.ahj.2015.02.016.Peer-Reviewed Original ResearchConceptsInhospital cardiac arrestLong-term mortalityHospital cardiac arrestCardiac arrestICD treatmentLower long-term mortalityImplantable cardioverter-defibrillator therapyHigh illness acuityHigher unadjusted mortalityICD-treated patientsCardiac Arrest RegistryCardioverter-defibrillator therapyPulseless ventricular tachycardiaHigh-risk populationComparative effectiveness studiesLong-term survivalPropensity score analysisLower mortality rateArrest etiologyEligible survivorsICD trialsHospital deathICD therapyIndex hospitalizationUntreated patients
2014
Readmission Rates and Long-Term Hospital Costs Among Survivors of an In-Hospital Cardiac Arrest
Chan PS, Nallamothu BK, Krumholz HM, Curtis LH, Li Y, Hammill BG, Spertus JA. Readmission Rates and Long-Term Hospital Costs Among Survivors of an In-Hospital Cardiac Arrest. Circulation Cardiovascular Quality And Outcomes 2014, 7: 889-895. PMID: 25351479, PMCID: PMC4241155, DOI: 10.1161/circoutcomes.114.000925.Peer-Reviewed Original ResearchConceptsHospital cardiac arrestCardiac arrestInpatient costsMean inpatient costsLarge national registryInpatient resource useNeurological statusReadmission patternsHospital dispositionPatient demographicsReadmission ratesMean ageInpatient useNational registryYounger ageReadmissionArrestAgeYearsDaysPatientsRegistryResource useSurvivors
2013
Association Between a Hospital’s Quality Performance for In-Hospital Cardiac Arrest and Common Medical Conditions
Chen LM, Nallamothu BK, Krumholz HM, Spertus JA, Tang F, Chan PS. Association Between a Hospital’s Quality Performance for In-Hospital Cardiac Arrest and Common Medical Conditions. Circulation Cardiovascular Quality And Outcomes 2013, 6: 700-707. PMID: 24221831, PMCID: PMC4465597, DOI: 10.1161/circoutcomes.113.000377.Peer-Reviewed Original ResearchConceptsCommon medical conditionsHospital survival rateAcute myocardial infarctionCardiac arrestMedical conditionsSurvival rateInpatient survivalHeart failureMyocardial infarctionMortality rateHospital cardiac arrest registryHospital qualityIn-Hospital Cardiac ArrestRisk-standardized mortality ratesCardiac Arrest RegistryCardiac arrest outcomesCardiac arrest patientsHospital cardiac arrestCardiac arrest survival ratesPublic reportingHospital outcomesArrest patientsHospital CompareArrest outcomesHospitalLong-Term Outcomes in Elderly Survivors of In-Hospital Cardiac Arrest
Chan PS, Nallamothu BK, Krumholz HM, Spertus JA, Li Y, Hammill BG, Curtis LH. Long-Term Outcomes in Elderly Survivors of In-Hospital Cardiac Arrest. New England Journal Of Medicine 2013, 368: 1019-1026. PMID: 23484828, PMCID: PMC3652256, DOI: 10.1056/nejmoa1200657.Peer-Reviewed Original ResearchConceptsHospital cardiac arrestCardiac arrestNeurologic disabilityReadmission ratesElderly survivorsRisk-adjusted ratesNeurologic statusHeart failureIn-Hospital Cardiac ArrestInpatient cardiac arrestsSevere neurologic disabilityDemographic characteristicsLong-term outcomesLong-term survivalYears of ageRate of survivalHospital dischargeOlder patientsYounger patientsWhite patientsBlack patientsTerm outcomesNational registryMedicare filesPatientsDuration of resuscitation efforts and survival after in-hospital cardiac arrest – Authors' reply
Goldberger ZD, Chan PS, Cooke CR, Hayward RA, Krumholz HM, Nallamothu BK. Duration of resuscitation efforts and survival after in-hospital cardiac arrest – Authors' reply. The Lancet 2013, 381: 447. PMID: 23399066, DOI: 10.1016/s0140-6736(13)60241-x.Peer-Reviewed Original Research
2012
Trends in Survival after In-Hospital Cardiac Arrest
Girotra S, Nallamothu BK, Spertus JA, Li Y, Krumholz HM, Chan PS. Trends in Survival after In-Hospital Cardiac Arrest. New England Journal Of Medicine 2012, 367: 1912-1920. PMID: 23150959, PMCID: PMC3517894, DOI: 10.1056/nejmoa1109148.Peer-Reviewed Original ResearchConceptsHospital cardiac arrestPulseless electrical activityCardiac arrestRisk-adjusted ratesNeurologic disabilityIn-Hospital Cardiac ArrestAcute resuscitation survivalGuidelines-Resuscitation registrySignificant neurologic disabilityQuality improvement registryPulseless ventricular tachycardiaElectrical activityInitial rhythmNeurologic outcomePostresuscitation careAcute resuscitationNeurologic functionSurvival improvementPostresuscitation survivalResuscitation careVentricular tachycardiaRhythm groupVentricular fibrillationMultivariable regressionSurvivalDuration of resuscitation efforts and survival after in-hospital cardiac arrest: an observational study
Goldberger ZD, Chan PS, Berg RA, Kronick SL, Cooke CR, Lu M, Banerjee M, Hayward RA, Krumholz HM, Nallamothu BK, Investigators F. Duration of resuscitation efforts and survival after in-hospital cardiac arrest: an observational study. The Lancet 2012, 380: 1473-1481. PMID: 22958912, PMCID: PMC3535188, DOI: 10.1016/s0140-6736(12)60862-9.Peer-Reviewed Original ResearchConceptsHospital cardiac arrestSpontaneous circulationCardiac arrestResuscitation attemptsMedian durationResuscitation effortsGuidelines-Resuscitation registryDuration of resuscitationRisk-adjusted survivalHigh-risk populationAmerican Heart AssociationPrimary endpointHospital dischargeHeart AssociationObservational studyPatientsUS hospitalsClinical Scholars ProgramSurvival rateHospitalResuscitationHigher survival rateSurvivalNational InstituteHigher likelihoodA Validated Prediction Tool for Initial Survivors of In-Hospital Cardiac Arrest
Chan PS, Spertus JA, Krumholz HM, Berg RA, Li Y, Sasson C, Nallamothu BK, Investigators F. A Validated Prediction Tool for Initial Survivors of In-Hospital Cardiac Arrest. JAMA Internal Medicine 2012, 172: 947-953. PMID: 22641228, PMCID: PMC3517176, DOI: 10.1001/archinternmed.2012.2050.Peer-Reviewed Original ResearchConceptsFavorable neurological survivalHospital cardiac arrestNeurological survivalCardiac arrestNeurological statusDerivation cohortValidation cohortInitial cardiac arrest rhythmIn-Hospital Cardiac ArrestBaseline neurological statusFavorable neurological statusGuidelines-Resuscitation registryCardiac arrest rhythmSevere neurological deficitsPulseless ventricular tachycardiaMultivariate logistic regressionSimple prediction toolRenal insufficiencyArrest rhythmNeurological deficitsHepatic insufficiencyMechanical ventilationMalignant diseaseVentricular tachycardiaInitial survivors
2010
Automated External Defibrillators and Survival After In-Hospital Cardiac Arrest
Chan PS, Krumholz HM, Spertus JA, Jones PG, Cram P, Berg RA, Peberdy MA, Nadkarni V, Mancini ME, Nallamothu BK, Investigators F. Automated External Defibrillators and Survival After In-Hospital Cardiac Arrest. JAMA 2010, 304: 2129-2136. PMID: 21078809, PMCID: PMC3587791, DOI: 10.1001/jama.2010.1576.Peer-Reviewed Original ResearchConceptsHospital cardiac arrestCardiac arrestAED useHospital dischargeHospitalized patientsShockable rhythmNonshockable rhythmsIn-Hospital Cardiac ArrestMultivariable hierarchical regressionGeneral hospital wardsEntire study populationExternal defibrillatorsPropensity score analysisUse of AEDsCohort studyImproved survivalPatient factorsStudy populationMAIN OUTCOMEPatientsHospital wardsUS hospitalsHospital sitesHospital unitsAEDs
2009
Racial Differences in Survival After In-Hospital Cardiac Arrest
Chan PS, Nichol G, Krumholz HM, Spertus JA, Jones PG, Peterson ED, Rathore SS, Nallamothu BK, Investigators F. Racial Differences in Survival After In-Hospital Cardiac Arrest. JAMA 2009, 302: 1195-1201. PMID: 19755698, PMCID: PMC2795316, DOI: 10.1001/jama.2009.1340.Peer-Reviewed Original ResearchConceptsHospital cardiac arrestCardiac arrestBlack patientsWhite patientsSuccessful resuscitationPostresuscitation survivalRacial differencesHospital sitesIn-Hospital Cardiac ArrestLower ratesPulseless ventricular tachycardiaRate of survivalCohort studyHospital dischargePatient characteristicsClinical factorsImmediate resuscitationPostresuscitation periodNational registryVentricular tachycardiaHospital CenterVentricular fibrillationCardiopulmonary resuscitationAdditional adjustmentPatientsHospital Variation in Time to Defibrillation After In-Hospital Cardiac Arrest
Chan PS, Nichol G, Krumholz HM, Spertus JA, Nallamothu BK. Hospital Variation in Time to Defibrillation After In-Hospital Cardiac Arrest. JAMA Internal Medicine 2009, 169: 1265-1273. PMID: 19636027, DOI: 10.1001/archinternmed.2009.196.Peer-Reviewed Original ResearchConceptsCardiac arrestHospital factorsHospital variationIn-Hospital Cardiac ArrestHospital-level effectsHospital cardiac arrestWorse survivalImproved survivalPatient factorsAdult inpatientsHospital predictorsNational registryHospital ratesCardiopulmonary resuscitationGreater oddsIdentical covariatesDefibrillation delaysHospitalDefibrillationDefibrillation timeSurvivalArrestWide variationPatientsInpatients
2008
Delayed Time to Defibrillation after In-Hospital Cardiac Arrest
S. C, M. K, Graham N, K. N, Investigators T. Delayed Time to Defibrillation after In-Hospital Cardiac Arrest. New England Journal Of Medicine 2008, 358: 9-17. PMID: 18172170, DOI: 10.1056/nejmoa0706467.Peer-Reviewed Original ResearchMeSH KeywordsAgedComorbidityElectric CountershockFemaleHeart ArrestHeart FailureHospital Bed CapacityHospital MortalityHospitalizationHumansLogistic ModelsMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionRetrospective StudiesSurvival AnalysisTachycardia, VentricularTime FactorsVentricular FibrillationConceptsHospital cardiac arrestCardiac arrestHospital dischargeIn-Hospital Cardiac ArrestOverall median timePulseless ventricular tachycardiaMultivariable logistic regressionLower ratesMedian timeVentricular arrhythmiasBlack raceHospital characteristicsNational registryVentricular tachycardiaCardiopulmonary resuscitationExpert guidelinesVentricular fibrillationHospital unitsLogistic regressionPatientsDefibrillationSurvivalArrestHospitalMinutes of delay
2004
ACC/AHA Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction—Executive Summary
Antman EM, Anbe DT, Armstrong PW, Bates ER, Green LA, Hand M, Hochman JS, Krumholz HM, Kushner FG, Lamas GA, Mullany CJ, Ornato JP, Pearle DL, Sloan MA, Smith SC, Antman E, Smith S, Alpert J, Anderson J, Faxon D, Fuster V, Gibbons R, Gregoratos G, Halperin J, Hiratzka L, Hunt S, Jacobs A, Ornato J. ACC/AHA Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction—Executive Summary. Circulation 2004, 110: 588-636. PMID: 15289388, DOI: 10.1161/01.cir.0000134791.68010.fa.Peer-Reviewed Original ResearchAdultAge FactorsAgedAmerican Heart AssociationAngioplasty, Balloon, CoronaryCardiovascular AgentsCombined Modality TherapyContraindicationsCoronary AngiographyCoronary Artery BypassCoronary Care UnitsDecision TreesDiagnosis, DifferentialEarly DiagnosisElectrocardiographyEmergency Medical ServicesEmergency Service, HospitalFemaleGuideline AdherenceHeart ArrestHeart Conduction SystemHumansMaleMiddle AgedMyocardial InfarctionOutcome Assessment, Health CarePatient DischargePatient Education as TopicPatient SelectionRisk AssessmentRisk FactorsSeverity of Illness IndexSex FactorsSurvival AnalysisThrombolytic TherapyUnited StatesACC/AHA Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction—Executive Summary A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 1999 Guidelines for the Management of Patients With Acute Myocardial Infarction)
Antman EM, Anbe DT, Armstrong PW, Bates ER, Green LA, Hand M, Hochman JS, Krumholz HM, Kushner FG, Lamas GA, Mullany CJ, Ornato JP, Pearle DL, Sloan MA, Smith SC, Antman E, Smith S, Alpert J, Anderson J, Faxon D, Fuster V, Gibbons R, Gregoratos G, Halperin J, Hiratzka L, Hunt S, Jacobs A, Ornato J. ACC/AHA Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction—Executive Summary A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 1999 Guidelines for the Management of Patients With Acute Myocardial Infarction). Journal Of The American College Of Cardiology 2004, 44: 671-719. PMID: 15358045, DOI: 10.1016/j.jacc.2004.07.002.Peer-Reviewed Original ResearchMeSH KeywordsAngioplasty, Balloon, CoronaryCardiovascular AgentsContraindicationsCoronary AngiographyCoronary Artery BypassCoronary Care UnitsDecision TreesDiagnosis, DifferentialEarly DiagnosisEmergency Medical ServicesEmergency Service, HospitalHeart ArrestHeart Conduction SystemHumansMyocardial InfarctionOutcome Assessment, Health CarePatient DischargePatient Education as TopicRisk AssessmentRisk FactorsSeverity of Illness IndexThrombolytic Therapy
1999
Comparing AMI Mortality Among Hospitals in Patients 65 Years of Age and Older
Krumholz H, Chen J, Wang Y, Radford M, Chen Y, Marciniak T. Comparing AMI Mortality Among Hospitals in Patients 65 Years of Age and Older. Circulation 1999, 99: 2986-2992. PMID: 10368115, DOI: 10.1161/01.cir.99.23.2986.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionMyocardial infarctionWhite blood cell countPatients 65 yearsSystolic blood pressureCongestive heart failureMedical chart reviewReceiver-operating characteristic curveBlood cell countRisk-adjusted outcomesYears of ageAdministrative billing codesRisk-adjustment modelsHospital outcomesSerum creatinineChart reviewDerivation cohortHeart failurePatient characteristicsBlood pressureCardiac arrestValidation cohortCandidate predictor variablesAMI mortalityBilling codes