2004
Adverse Effects of β-Blocker Therapy for Patients With Heart Failure: A Quantitative Overview of Randomized Trials
Ko DT, Hebert PR, Coffey CS, Curtis JP, Foody JM, Sedrakyan A, Krumholz HM. Adverse Effects of β-Blocker Therapy for Patients With Heart Failure: A Quantitative Overview of Randomized Trials. JAMA Internal Medicine 2004, 164: 1389-1394. PMID: 15249347, DOI: 10.1001/archinte.164.13.1389.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAgedBisoprololBradycardiaCarbazolesCarvedilolDizzinessFatigueFemaleFollow-Up StudiesHeart Conduction SystemHeart FailureHumansHypotensionMaleMetoprololMiddle AgedPropanolaminesRisk FactorsRisk Reduction BehaviorSeverity of Illness IndexStatistics as TopicTreatment FailureVentricular Dysfunction, LeftWithholding TreatmentConceptsBeta-blocker therapyHeart failureAdverse effectsLeft ventricular systolic dysfunctionBeta-blocker trialsCardiovascular adverse effectsChronic heart failureHeart Failure TrialVentricular systolic dysfunctionΒ-blocker therapyRisk of hypotensionLife-saving therapyRandom-effects modelHF hospitalizationCause mortalitySystolic dysfunctionCause withdrawalsFailure TrialRandomized trialsAbsolute riskElectronic searchPatientsMEDLINE databaseTherapyAbsolute increase
2003
Review: Beta-blockers increase fatigue and sexual dysfunction but not depression after myocardial infarction.
Ko DT, Hebert PR, Krumholz HM. Review: Beta-blockers increase fatigue and sexual dysfunction but not depression after myocardial infarction. Annals Of Internal Medicine 2003, 138: 30; author reply 30. PMID: 12511138, DOI: 10.7326/acpjc-2003-138-1-030.Peer-Reviewed Original Research
2002
β-Blocker Therapy and Symptoms of Depression, Fatigue, and Sexual Dysfunction
Ko DT, Hebert PR, Coffey CS, Sedrakyan A, Curtis JP, Krumholz HM. β-Blocker Therapy and Symptoms of Depression, Fatigue, and Sexual Dysfunction. JAMA 2002, 288: 351-357. PMID: 12117400, DOI: 10.1001/jama.288.3.351.Peer-Reviewed Original ResearchConceptsBeta-blocker therapySexual dysfunctionDepressive symptomsSymptoms of depressionAdverse eventsHeart failureMyocardial infarctionSignificant annual increaseAdditional reportsLipid solubilityAdverse effectsWithdrawal of therapyΒ-blocker therapyPatient-reported symptomsNumber of patientsEnglish-language articlesInclusion of trialsPlacebo groupMortality benefitRandomized trialsStudy treatmentCardiac patientsPlacebo controlRisk of fatigueClinical trials
2001
Symptom Predictors of Acute Coronary Syndromes in Younger and Older Patients
Milner K, Funk M, Richards S, Vaccarino V, Krumholz H. Symptom Predictors of Acute Coronary Syndromes in Younger and Older Patients. Nursing Research 2001, 50: 233-241. PMID: 11480532, DOI: 10.1097/00006199-200107000-00007.Peer-Reviewed Original ResearchConceptsAcute coronary syndromeOlder patientsYounger patientsChest symptomsSymptom predictorsTypical symptomsCoronary syndromeRegional cardiac referral centerCardiac referral centerInitiation of treatmentLogistic regression analysisPositive predictorArm painReferral centerPatient ageAtypical symptomsEmergency departmentAppropriate triageBorderline associationSymptom presentPatient decisionGreater oddsPatientsSignificant negative predictorPatient's presence