2023
Severe aortic stenosis detection by deep learning applied to echocardiography
Holste G, Oikonomou E, Mortazavi B, Coppi A, Faridi K, Miller E, Forrest J, McNamara R, Ohno-Machado L, Yuan N, Gupta A, Ouyang D, Krumholz H, Wang Z, Khera R. Severe aortic stenosis detection by deep learning applied to echocardiography. European Heart Journal 2023, 44: 4592-4604. PMID: 37611002, PMCID: PMC11004929, DOI: 10.1093/eurheartj/ehad456.Peer-Reviewed Original ResearchConceptsSevere aortic stenosisReclassification of moderate aortic stenosis based on data-driven phenotyping of hemodynamic progression
Cho I, Kim W, Kim S, Ko K, Seong Y, Kim D, Seo J, Shim C, Ha J, Mori M, Gupta A, You S, Hong G, Krumholz H. Reclassification of moderate aortic stenosis based on data-driven phenotyping of hemodynamic progression. Scientific Reports 2023, 13: 6694. PMID: 37095171, PMCID: PMC10125992, DOI: 10.1038/s41598-023-33683-1.Peer-Reviewed Original ResearchConceptsRapid progression groupModerate aortic stenosisAortic valve replacementSlow progression groupAortic stenosisProgression groupHemodynamic progressionRapid progressionMore rapid progressionLatent class trajectory modelingTransthoracic echocardiography studyBetween-group differencesData-driven phenotypingPressure gradient measurementAVR ratesModerate ASCause mortalityValve replacementEchocardiography studyAtrial fibrillationTTE studiesEchocardiographic dataRisk factorsPredictive valuePatients
2021
Characteristics, interventions and outcomes of patients with valvular heart disease hospitalised in China: a cross-sectional study
Huang X, Dhruva SS, Yuan X, Bai X, Lu Y, Yan X, Liu J, Li W, Hu D, Ji R, Gao M, Miao F, Li J, Ge J, Krumholz HM, Li J. Characteristics, interventions and outcomes of patients with valvular heart disease hospitalised in China: a cross-sectional study. BMJ Open 2021, 11: e052946. PMID: 34732492, PMCID: PMC8572400, DOI: 10.1136/bmjopen-2021-052946.Peer-Reviewed Original ResearchMeSH KeywordsAgedCross-Sectional StudiesEchocardiographyHeart Valve DiseasesHumansMaleMitral Valve InsufficiencyTricuspid Valve InsufficiencyConceptsSevere valvular heart diseaseValvular heart diseaseHigh operative riskRheumatic originValve interventionHospital outcomesOperative riskCommon etiologyPrimary diagnosisHeart diseaseSeverity of VHDTypes of VHDCommon valvular heart diseaseMultivariable logistic regression analysisDegenerative valvular heart diseaseOutcomes of patientsCross-sectional studyLogistic regression analysisTwo-stage random sampling designClinical characteristicsFrequent etiologyPredominant etiologyTricuspid regurgitationAdult patientsPatient characteristicsScope of Practice of US Interventional Cardiologists from an Analysis of Medicare Billing Data
Murugiah K, Chen L, Castro-Dominguez Y, Khera R, Krumholz HM. Scope of Practice of US Interventional Cardiologists from an Analysis of Medicare Billing Data. The American Journal Of Cardiology 2021, 160: 40-45. PMID: 34610872, DOI: 10.1016/j.amjcard.2021.08.041.Peer-Reviewed Original Research
2012
2012 ACCF/AHA/ACP/AATS/PCNA/SCAI/STS Guideline for the Diagnosis and Management of Patients With Stable Ischemic Heart Disease
Fihn SD, Gardin JM, Abrams J, Berra K, Blankenship JC, Dallas AP, Douglas PS, Foody JM, Gerber TC, Hinderliter AL, King SB, Kligfield PD, Krumholz HM, Kwong RY, Lim MJ, Linderbaum JA, Mack MJ, Munger MA, Prager RL, Sabik JF, Shaw LJ, Sikkema JD, Smith CR, Smith SC, Spertus JA, Williams SV, Anderson JL. 2012 ACCF/AHA/ACP/AATS/PCNA/SCAI/STS Guideline for the Diagnosis and Management of Patients With Stable Ischemic Heart Disease. Circulation 2012, 126: e354-e471. PMID: 23166211, DOI: 10.1161/cir.0b013e318277d6a0.Peer-Reviewed Original Research
2006
Detection of Heart Transplant Rejection in Adults by Echocardiographic Diastolic Indices: A Systematic Review of the Literature
Mena C, Wencker D, Krumholz HM, McNamara RL. Detection of Heart Transplant Rejection in Adults by Echocardiographic Diastolic Indices: A Systematic Review of the Literature. Journal Of The American Society Of Echocardiography 2006, 19: 1295-1300. PMID: 17000376, DOI: 10.1016/j.echo.2006.04.029.Peer-Reviewed Original Research
1997
Validation of a clinical prediction rule for left ventricular ejection fraction after myocardial infarction in patients ≥ 65 years old
Krumholz H, Howes C, Murillo J, Vaccarino L, Radford M, Ellerbeck E. Validation of a clinical prediction rule for left ventricular ejection fraction after myocardial infarction in patients ≥ 65 years old. The American Journal Of Cardiology 1997, 80: 11-15. PMID: 9205012, DOI: 10.1016/s0002-9149(97)00299-3.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCohort StudiesConnecticutEchocardiographyElectrocardiographyFemaleHumansMaleMedicareMultivariate AnalysisMyocardial InfarctionPilot ProjectsPredictive Value of TestsRetrospective StudiesRisk FactorsStroke VolumeTreatment OutcomeUnited StatesVentricular Function, LeftConceptsLeft ventricular ejection fractionAcute myocardial infarctionClinical prediction ruleVentricular ejection fractionPositive predictive valuePrediction ruleElderly patientsEjection fractionMyocardial infarctionExclusion criteriaPredictive valueEligible elderly patientsRetrospective chart reviewConnecticut cohortChest painBypass surgeryChart reviewDiabetes mellitusMedicare patientsPatientsPilot studyMultivariate modelInfarctionElectrocardiogram interpretationOriginal studyReporting ejection fraction after myocardial infarction: an opportunity for quality improvement in echocardiography.
Goldberg DJ, Radford MJ, Krumholz HM. Reporting ejection fraction after myocardial infarction: an opportunity for quality improvement in echocardiography. Connecticut Medicine 1997, 61: 143-5. PMID: 9097485.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overEchocardiographyFemaleHumansMaleMedical RecordsMyocardial InfarctionVentricular Function, LeftConceptsMyocardial infarctionEjection fractionLeft ventricular ejection fractionVentricular ejection fractionVentricular systolic functionAcute myocardial infarctionCare of patientsSystolic functionVentricular functionEchocardiography studyMedicare beneficiariesInfarctionEchocardiographyReportPrincipal findings
1996
Cardiac Risk of Noncardiac Surgery in Patients with Asymmetric Septal Hypertrophy
Haering M, Comunale M, Parker R, Lowenstein E, Douglas P, Krumholz H, Manning W. Cardiac Risk of Noncardiac Surgery in Patients with Asymmetric Septal Hypertrophy. Anesthesiology 1996, 85: 254-259. PMID: 8712439, DOI: 10.1097/00000542-199608000-00005.Peer-Reviewed Original ResearchConceptsAdverse cardiac eventsAsymmetric septal hypertrophyAdverse perioperative cardiac eventsPerioperative cardiac eventsCongestive heart failureCardiac eventsNoncardiac surgerySeptal hypertrophyHeart failureMajor surgeryCardiac riskMyocardial infarctionImportant independent risk factorOutflow tract gradientPercent of patientsDuration of surgeryIndependent risk factorLength of surgerySystolic anterior motionPrior myocardial infarctionCoronary artery diseaseType of anesthesiaAnterior mitral leafletEmergent cardioversionTract gradientComparison and reproducibility of visual echocardiographic and quantitative radionyclide left ventricular ejection fractions
van Royen N, Jaffe C, Krumholz H, Johnson K, Lynch P, Natale D, Atkinson P, Demon P, Wackers F. Comparison and reproducibility of visual echocardiographic and quantitative radionyclide left ventricular ejection fractions. The American Journal Of Cardiology 1996, 77: 843-850. PMID: 8623737, DOI: 10.1016/s0002-9149(97)89179-5.Peer-Reviewed Original ResearchConceptsEquilibrium radionuclide angiographyVentricular ejection fractionEjection fractionRadionuclide angiographyEchocardiographic LVEFEquilibrium radionuclideRadionuclide LVEFClinical relevanceLeft ventricular ejection fractionCorrelation of LVEFDetermination of LVEFPatient management decisionsPotential clinical relevanceRelevant differencesInter-observer reproducibilityStable patientsLV functionLimits of agreementLVEFIndividual patientsRepeat assessmentEchocardiographyAngiographyBlinded analysisRepeat analysis
1995
Prognosis of left ventricular geometric patterns in the Framingham heart study
Krumholz H, Larson M, Levy D. Prognosis of left ventricular geometric patterns in the Framingham heart study. Journal Of The American College Of Cardiology 1995, 25: 879-884. PMID: 7884091, DOI: 10.1016/0735-1097(94)00473-4.Peer-Reviewed Original ResearchConceptsCardiovascular risk factorsLeft ventricular massTraditional cardiovascular risk factorsLeft ventricular geometric patternsVentricular geometric patternsVentricular massConcentric hypertrophyLeft ventricular geometryRisk factorsPopulation-based sampleCardiovascular diseaseFramingham Heart StudyVentricular geometryConcentric remodelingEccentric hypertrophyHeart StudyNormal geometryCardiovascular disease risk factorsProportional hazards regression modelsLittle prognostic informationIncremental prognostic valueApparent cardiovascular diseaseIncident cardiovascular diseaseDisease risk factorsHazards regression models
1994
Clinical utility of transthoracic two-dimensional and Doppler echocardiography
Krumholz H, Douglas P, Goldman L, Waksmonski C. Clinical utility of transthoracic two-dimensional and Doppler echocardiography. Journal Of The American College Of Cardiology 1994, 24: 125-131. PMID: 8006255, DOI: 10.1016/0735-1097(94)90552-5.Peer-Reviewed Original ResearchConceptsNew diagnosisChart reviewEchocardiographic examinationMitral regurgitationClinical utilityLeft ventricular wall motion abnormalitiesTertiary care teaching hospitalVentricular wall motion abnormalitiesGreater mitral regurgitationProspective observational studyUse of echocardiographyWall motion abnormalitiesPharmacologic treatmentTransthoracic twoDoppler echocardiographyMotion abnormalitiesPhysician interviewsTeaching hospitalObservational studyEchocardiographyClinical practiceOutpatientsInpatientsPatient diagnosisContemporary echocardiography
1993
Sex differences in cardiac adaptation to isolated systolic hypertension
Krumholz H, Larson M, Levy D. Sex differences in cardiac adaptation to isolated systolic hypertension. The American Journal Of Cardiology 1993, 72: 310-313. PMID: 8342510, DOI: 10.1016/0002-9149(93)90678-6.Peer-Reviewed Original ResearchConceptsSystolic hypertensionLV massBlood pressureLV hypertrophyApparent cardiovascular diseaseDiastolic blood pressureBody mass indexLeft ventricular massLV wall thicknessM-mode echocardiographyM-mode echocardiogramsFramingham Offspring StudyBlood glucose levelsFramingham Heart StudyAntihypertensive medicationsDiastolic hypertensionNormotensive subjectsConcentric hypertrophyLV dilationMass indexIndex examinationChamber enlargementVentricular massCardiac adaptationCardiovascular diseaseCardioversion from Atrial Fibrillation without Prolonged Anticoagulation with Use of Transesophageal Echocardiography to Exclude the Presence of Atrial Thrombi
Manning W, Silverman D, Gordon S, Krumholz H, Douglas P. Cardioversion from Atrial Fibrillation without Prolonged Anticoagulation with Use of Transesophageal Echocardiography to Exclude the Presence of Atrial Thrombi. New England Journal Of Medicine 1993, 328: 750-755. PMID: 8437595, DOI: 10.1056/nejm199303183281102.Peer-Reviewed Original ResearchConceptsAtrial thrombusLong-term anticoagulationAtrial fibrillationTransesophageal echocardiographyOral anticoagulationEarly cardioversionTransthoracic echocardiographyLong-term oral anticoagulationConventional noninvasive techniquesOral anticoagulation therapyShort-term anticoagulationPresence of thrombusAnticoagulation therapyEmbolic eventsQualifying patientsConsecutive patientsProlonged anticoagulationSuccessful cardioversionSinus rhythmAnticoagulationCardioversionEchocardiographyPatientsThrombusFibrillation