2017
Is Hemoglobin A1c the Right Outcome for Studies of Diabetes?
Lipska KJ, Krumholz HM. Is Hemoglobin A1c the Right Outcome for Studies of Diabetes? JAMA 2017, 317: 1017-1018. PMID: 28125758, PMCID: PMC5350060, DOI: 10.1001/jama.2017.0029.Commentaries, Editorials and Letters
2011
Use of GLP-1 analogues needs great caution
Yudkin JS, Lehman R, Krumholz HM. Use of GLP-1 analogues needs great caution. The BMJ 2011, 342: d1478. PMID: 21385813, DOI: 10.1136/bmj.d1478.Peer-Reviewed Original Research
2009
Elevated Admission Glucose and Mortality in Elderly Patients Hospitalized With Heart Failure
Kosiborod M, Inzucchi SE, Spertus JA, Wang Y, Masoudi FA, Havranek EP, Krumholz HM. Elevated Admission Glucose and Mortality in Elderly Patients Hospitalized With Heart Failure. Circulation 2009, 119: 1899-1907. PMID: 19332465, DOI: 10.1161/circulationaha.108.821843.Peer-Reviewed Original ResearchConceptsHeart failureAdmission glucoseElderly patientsDiabetes mellitusAdverse outcomesMultivariable Cox regression modelsAdmission glucose levelsElevated admission glucoseAcute myocardial infarctionCox regression modelCause mortalityMultivariable adjustmentEntire cohortGlucose controlMyocardial infarctionCardiovascular conditionsGlucose levelsLarge cohortElevated glucoseRepresentative cohortPatientsSignificant associationMortalityCohortMellitusTight control of blood glucose in long standing type 2 diabetes
Lehman R, Krumholz HM. Tight control of blood glucose in long standing type 2 diabetes. The BMJ 2009, 338: b800. PMID: 19264821, DOI: 10.1136/bmj.b800.Peer-Reviewed Original ResearchMeSH KeywordsBlood GlucoseDiabetes Mellitus, Type 2Diabetic AngiopathiesFemaleGlycated HemoglobinHumansPregnancy
2005
Thiazolidinediones, Metformin, and Outcomes in Older Patients With Diabetes and Heart Failure
Masoudi FA, Inzucchi SE, Wang Y, Havranek EP, Foody JM, Krumholz HM. Thiazolidinediones, Metformin, and Outcomes in Older Patients With Diabetes and Heart Failure. Circulation 2005, 111: 583-590. PMID: 15699279, DOI: 10.1161/01.cir.0000154542.13412.b1.Peer-Reviewed Original ResearchConceptsHeart failureInsulin-sensitizing drugsOlder patientsLower riskCox proportional hazards modelAntidiabetic drug prescriptionRetrospective cohort studyPrincipal discharge diagnosisClustering of patientsProportional hazards modelCohort studySecondary outcomesPrimary outcomeMetformin treatmentRandomized trialsThiazolidinedione treatmentDischarge diagnosisInsulin sensitizersAdverse outcomesDrug prescriptionsMultivariable modelObservational studyHospital variablesThiazolidinedione classHigh risk
1999
Beta-blocker therapy for secondary prevention of myocardial infarction in elderly diabetic patients
Chen J, Marciniak T, Radford M, Wang Y, Krumholz H. Beta-blocker therapy for secondary prevention of myocardial infarction in elderly diabetic patients. Journal Of The American College Of Cardiology 1999, 34: 1388-1394. PMID: 10551683, DOI: 10.1016/s0735-1097(99)00383-6.Peer-Reviewed Original ResearchConceptsBeta-blocker therapyElderly diabetic patientsAcute myocardial infarctionInsulin-treated diabeticsOne-year mortalityDiabetic patientsDiabetic complicationsMyocardial infarctionNational Cooperative Cardiovascular ProjectSix-month readmission ratesOne-year mortality rateRetrospective cohort studyRisk of readmissionHospital medical recordsCooperative Cardiovascular ProjectCommunity practice settingsElderly diabeticsCohort studyComplication rateReadmission ratesSecondary preventionClinical factorsHospital readmissionRandomized trialsPotential confounders