2017
Perspectives from NHLBI Global Health Think Tank Meeting for Late Stage (T4) Translation Research
Engelgau MM, Peprah E, Sampson UKA, Mishoe H, Benjamin IJ, Douglas PS, Hochman JS, Ridker PM, Brandes N, Checkley W, El-Saharty S, Ezzati M, Hennis A, Jiang L, Krumholz HM, Lamourelle G, Makani J, Narayan KMV, Ohene-Frempong K, Straus SE, Stuckler D, Chambers DA, Belis D, Bennett GC, Boyington JE, Creazzo TL, de Jesus JM, Krishnamurti C, Lowden MR, Punturieri A, Shero ST, Young NS, Zou S, Mensah GA. Perspectives from NHLBI Global Health Think Tank Meeting for Late Stage (T4) Translation Research. Global Heart 2017, 12: 341-348. PMID: 27452772, DOI: 10.1016/j.gheart.2016.03.640.Peer-Reviewed Original ResearchMeSH KeywordsCongresses as TopicDisease ManagementGlobal HealthGuidelines as TopicHumansMorbidityNoncommunicable DiseasesTranslational Research, BiomedicalConceptsNational HeartDisease burdenNoncommunicable disease burdenHealth delivery modelsGlobal health researchMiddle-income countriesBlood InstituteGlobal health disparitiesThink Tank meetingHealth disparitiesEffective interventionsCompelling scientific questionsLungTank meetingHealth researchSustainable interventionsHeartThree-quartersDelivery modelInterventionBurdenImplementation strategiesResearch capacityMajor themesLater stagesPriorities for Cardiovascular Outcomes Research
Khazanie P, Krumholz HM, Kiefe CI, Kressin NR, Wells B, Wang TY, Peterson ED. Priorities for Cardiovascular Outcomes Research. Circulation Cardiovascular Quality And Outcomes 2017, 10: e001967. PMID: 28710296, PMCID: PMC7811766, DOI: 10.1161/circoutcomes.115.001967.Peer-Reviewed Original ResearchCardiologyCost-Benefit AnalysisDelivery of Health CareHealth Care CostsHealth Services ResearchHumansInterdisciplinary CommunicationNational Heart, Lung, and Blood Institute (U.S.)Organizational ObjectivesOutcome Assessment, Health CarePatient-Centered CarePublic-Private Sector PartnershipsStakeholder ParticipationTranslational Research, BiomedicalUnited States
2016
Slow Gait Speed and Risk of Mortality or Hospital Readmission After Myocardial Infarction in the Translational Research Investigating Underlying Disparities in Recovery from Acute Myocardial Infarction: Patients' Health Status Registry
Dodson JA, Arnold SV, Gosch KL, Gill TM, Spertus JA, Krumholz HM, Rich MW, Chaudhry SI, Forman DE, Masoudi FA, Alexander KP. Slow Gait Speed and Risk of Mortality or Hospital Readmission After Myocardial Infarction in the Translational Research Investigating Underlying Disparities in Recovery from Acute Myocardial Infarction: Patients' Health Status Registry. Journal Of The American Geriatrics Society 2016, 64: 596-601. PMID: 26926309, PMCID: PMC4803531, DOI: 10.1111/jgs.14016.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionMyocardial infarctionSlow gaitHospital readmissionGait speedOlder adultsCox proportional hazards regressionMarker of frailtySlow gait speedTranslational researchProportional hazards regressionOutcomes 1 yearRisk of mortalityAssessment 1 monthBaseline characteristicsObservational cohortClinical factorsDiabetes mellitusHeart failureHazards regressionPrognostic importancePrognostic valueHigh prevalenceInfarctionReadmission
2014
Managing the Information Boundary of an Organization
Krumholz HM, Downing NS. Managing the Information Boundary of an Organization. Circulation Cardiovascular Quality And Outcomes 2014, 7: 805-806. PMID: 25387775, PMCID: PMC4322936, DOI: 10.1161/circoutcomes.114.001500.Peer-Reviewed Original Research
2012
Physical function and independence 1 year after myocardial infarction: Observations from the Translational Research Investigating Underlying disparities in recovery from acute Myocardial infarction: Patients' Health status registry
Dodson JA, Arnold SV, Reid KJ, Gill TM, Rich MW, Masoudi FA, Spertus JA, Krumholz HM, Alexander KP. Physical function and independence 1 year after myocardial infarction: Observations from the Translational Research Investigating Underlying disparities in recovery from acute Myocardial infarction: Patients' Health status registry. American Heart Journal 2012, 163: 790-796. PMID: 22607856, PMCID: PMC3359897, DOI: 10.1016/j.ahj.2012.02.024.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAge FactorsAgedAngioplasty, Balloon, CoronaryAttitude to HealthCardiac CatheterizationCoronary AngiographyDepressionElectrocardiographyFemaleFollow-Up StudiesHealth SurveysHumansIncidenceIndependent LivingMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionPhysical FitnessPoisson DistributionPredictive Value of TestsQuality of LifeRegistriesRisk AssessmentSickness Impact ProfileSurveys and QuestionnairesSurvivorsTime FactorsTranslational Research, BiomedicalConceptsAcute myocardial infarctionPhysical function declineFunction declinePhysical functionMyocardial infarctionHealth statusEuroQol-5DUninsured statusTime of AMIShort Form-12 Physical Component ScoreIndependence lossEnd-stage renal diseasePost-acute myocardial infarctionCardiac rehabilitation referralPhysical component scorePatients' health statusQuality of lifePoisson regression modelsTRIUMPH registryRehabilitation referralRenal diseaseNonwhite raceFemale sexRisk factorsUnmarried statusBody Mass Index and Mortality in Acute Myocardial Infarction Patients
Bucholz EM, Rathore SS, Reid KJ, Jones PG, Chan PS, Rich MW, Spertus JA, Krumholz HM. Body Mass Index and Mortality in Acute Myocardial Infarction Patients. The American Journal Of Medicine 2012, 125: 796-803. PMID: 22483510, PMCID: PMC3408565, DOI: 10.1016/j.amjmed.2012.01.018.Peer-Reviewed Original ResearchConceptsBody mass indexHigher body mass indexAcute myocardial infarctionMyocardial infarctionLower mortalityObesity paradoxMass indexAssociation of BMIMedian body mass indexCox proportional hazards regressionAcute myocardial infarction patientsImpact of obesityRegistry of patientsProportional hazards regressionMyocardial infarction patientsContinuous variablesDomains of patientsDiabetes subgroupsClinical characteristicsMultivariable adjustmentHeart failurePatient characteristicsBMI groupsDiabetes mellitusHazards regression
2011
Translational Research Investigating Underlying Disparities in Acute Myocardial Infarction Patients' Health Status (TRIUMPH)
Arnold SV, Chan PS, Jones PG, Decker C, Buchanan DM, Krumholz HM, Ho PM, Spertus JA. Translational Research Investigating Underlying Disparities in Acute Myocardial Infarction Patients' Health Status (TRIUMPH). Circulation Cardiovascular Quality And Outcomes 2011, 4: 467-476. PMID: 21772003, PMCID: PMC3376532, DOI: 10.1161/circoutcomes.110.960468.Peer-Reviewed Original ResearchConceptsHealth status studiesMyocardial infarctionHealth statusPostdischarge careAcute Myocardial Infarction Patients' Health StatusSubset of patientsTranslational researchPost-MI outcomesRacial differencesHigh mortality ratePatients' health statusMI registryChart abstractionHospital dischargeWhite patientsBlack patientsVital statusMedical historyWorse outcomesTreatment characteristicsInpatient careBaseline interviewUS CentersBlood samplesPatients