2020
Evaluation of Case Volumes of a Heart Transplant Program and Short-term Outcomes After Changes in the United Network for Organ Sharing Donor Heart Allocation System
Mori M, Wilson L, Ali A, Ahmad T, Anwer M, Jacoby D, Geirsson A, Krumholz HM. Evaluation of Case Volumes of a Heart Transplant Program and Short-term Outcomes After Changes in the United Network for Organ Sharing Donor Heart Allocation System. JAMA Network Open 2020, 3: e2017513. PMID: 32945877, PMCID: PMC7501535, DOI: 10.1001/jamanetworkopen.2020.17513.Peer-Reviewed Original ResearchConceptsYale-New Haven HospitalHeart transplant programShort-term outcomesHeart transplantHeart transplant volumeNew Haven HospitalDonor heartsPatient selectionRecipient selectionTransplant programsTransplant volumeWaiting listCase volumeDonor heart allocation systemPre-post cohort studyConservative patient selectionUnused donor heartsHeart allocation systemHigher median numberCirculatory assist devicesCohort studyPatient characteristicsMore patientsSingle centerCenter volume
2016
China PEACE risk estimation tool for in-hospital death from acute myocardial infarction: an early risk classification tree for decisions about fibrinolytic therapy
Li X, Li J, Masoudi FA, Spertus JA, Lin Z, Krumholz HM, Jiang L. China PEACE risk estimation tool for in-hospital death from acute myocardial infarction: an early risk classification tree for decisions about fibrinolytic therapy. BMJ Open 2016, 6: e013355. PMID: 27798032, PMCID: PMC5093680, DOI: 10.1136/bmjopen-2016-013355.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionAcute myocardial infarctionFibrinolytic therapyLow-risk groupMyocardial infarctionHospital deathHospital mortalitySegment elevation myocardial infarctionCardiac Events (PEACE) studyHospital death riskComposite of deathElevation myocardial infarctionSystolic blood pressureTime of presentationRelative risk reductionCross-sectional studyBaseline mortality riskAcute reperfusionMajor bleedingReperfusion therapyBlood pressureDerivation cohortStudy cohortChina PatientValidation cohortParticipation of the elderly, women, and minorities in pivotal trials supporting 2011–2013 U.S. Food and Drug Administration approvals
Downing NS, Shah ND, Neiman JH, Aminawung JA, Krumholz HM, Ross JS. Participation of the elderly, women, and minorities in pivotal trials supporting 2011–2013 U.S. Food and Drug Administration approvals. Trials 2016, 17: 199. PMID: 27079511, PMCID: PMC4832528, DOI: 10.1186/s13063-016-1322-4.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsAgedClinical Trials as TopicCross-Sectional StudiesDatabases, FactualDrug ApprovalEthnicityFemaleHealth Status DisparitiesHealthcare DisparitiesHumansMaleMiddle AgedMinority GroupsPatient SelectionSex FactorsTime FactorsUnited StatesUnited States Food and Drug AdministrationConceptsSubgroup efficacy analysesPivotal trialsEfficacy analysisNovel therapeuticsSubgroup analysisTrial participantsU.S. FoodMean proportionAvailable FDA documentsCross-sectional studyDrug Administration approvalBasis of approvalYears of ageTrial patientsElderly patientsMedian ageBlack patientsAsian patientsAdministration approvalClinical studiesFDA reviewersPatientsHispanic participantsTrialsDemographic characteristics
2015
Appropriate Use Criteria for Coronary Revascularization and Trends in Utilization, Patient Selection, and Appropriateness of Percutaneous Coronary Intervention
Desai NR, Bradley SM, Parzynski CS, Nallamothu BK, Chan PS, Spertus JA, Patel MR, Ader J, Soufer A, Krumholz HM, Curtis JP. Appropriate Use Criteria for Coronary Revascularization and Trends in Utilization, Patient Selection, and Appropriateness of Percutaneous Coronary Intervention. JAMA 2015, 314: 2045-2053. PMID: 26551163, PMCID: PMC5459470, DOI: 10.1001/jama.2015.13764.Peer-Reviewed Original ResearchConceptsNonacute percutaneous coronary interventionPercutaneous coronary interventionAppropriate use criteriaInappropriate percutaneous coronary interventionHospital-level variationCoronary revascularizationPatient selectionUse criteriaCoronary interventionStudy periodAppropriateness of PCINational Cardiovascular Data Registry CathPCI RegistryProportion of PCIsMultivessel coronary artery diseaseHigh-risk findingsCoronary artery diseaseAnnual PCI volumesCross-sectional analysisAngina severityAntianginal medicationsAcute indicationsCathPCI RegistryArtery diseasePCI volumePCI procedures
2014
High Incarceration Rates Among Black Men Enrolled In Clinical Studies May Compromise Ability To Identify Disparities
Wang EA, Aminawung JA, Wildeman C, Ross JS, Krumholz HM. High Incarceration Rates Among Black Men Enrolled In Clinical Studies May Compromise Ability To Identify Disparities. Health Affairs 2014, 33: 848-855. PMID: 24799583, PMCID: PMC4065793, DOI: 10.1377/hlthaff.2013.1325.Peer-Reviewed Original ResearchConceptsClinical studiesHealth outcomesBlack menProspective clinical studyObservational clinical researchBlood InstituteNational HeartClinical researchWhite womenRacial disparitiesWhite menMinimal riskMenBlack womenHigh rateJail inmatesMinority populationsWomenOutcomesEffects of incarcerationImpact of incarcerationHigh incarceration ratesIncarcerationLungFollow
2013
Variations in Health Care, Patient Preferences, and High-Quality Decision Making
Krumholz HM. Variations in Health Care, Patient Preferences, and High-Quality Decision Making. JAMA 2013, 310: 151-152. PMID: 23839747, PMCID: PMC5459397, DOI: 10.1001/jama.2013.7835.Peer-Reviewed Original Research
2012
2013 ACCF/AHA Guideline for the Management of ST-Elevation Myocardial Infarction
O’Gara P, Kushner FG, Ascheim DD, Casey DE, Chung MK, de Lemos JA, Ettinger SM, Fang JC, Fesmire FM, Franklin BA, Granger CB, Krumholz HM, Linderbaum JA, Morrow DA, Newby LK, Ornato JP, Ou N, Radford MJ, Tamis-Holland JE, Tommaso JE, Tracy CM, Woo YJ, Zhao DX. 2013 ACCF/AHA Guideline for the Management of ST-Elevation Myocardial Infarction. Circulation 2012, 127: 529-555. PMID: 23247303, DOI: 10.1161/cir.0b013e3182742c84.Peer-Reviewed Original ResearchAmerican Heart AssociationCardiologyDiagnostic Techniques, CardiovascularDisease ManagementElectrocardiographyEmergency Medical ServicesEvidence-Based MedicineHumansMedication Therapy ManagementMyocardial InfarctionMyocardial ReperfusionPatient SelectionPercutaneous Coronary InterventionRisk AssessmentThrombolytic TherapyUnited States2013 ACCF/AHA Guideline for the Management of ST-Elevation Myocardial Infarction: Executive Summary A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines
O'Gara PT, Kushner FG, Ascheim DD, Casey DE, Chung MK, de Lemos JA, Ettinger SM, Fang JC, Fesmire FM, Franklin BA, Granger CB, Krumholz HM, Linderbaum JA, Morrow DA, Newby LK, Ornato JP, Ou N, Radford MJ, Tamis-Holland JE, Tommaso CL, Tracy CM, Woo YJ, Zhao DX. 2013 ACCF/AHA Guideline for the Management of ST-Elevation Myocardial Infarction: Executive Summary A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Journal Of The American College Of Cardiology 2012, 61: 485-510. PMID: 23256913, DOI: 10.1016/j.jacc.2012.11.018.Peer-Reviewed Original ResearchAmerican Heart AssociationCardiologyClinical ProtocolsDiagnostic Techniques, CardiovascularDisease ManagementElectrocardiographyEmergency Medical ServicesEvidence-Based MedicineHumansMedication Therapy ManagementMyocardial InfarctionMyocardial ReperfusionPatient SelectionPercutaneous Coronary InterventionRisk AssessmentThrombolytic TherapyUnited States2013 ACCF/AHA Guideline for the Management of ST-Elevation Myocardial Infarction A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines
O'Gara PT, Kushner FG, Ascheim DD, Casey DE, Chung MK, de Lemos JA, Ettinger SM, Fang JC, Fesmire FM, Franklin BA, Granger CB, Krumholz HM, Linderbaum JA, Morrow DA, Newby LK, Ornato JP, Ou N, Radford MJ, Tamis-Holland JE, Tommaso CL, Tracy CM, Woo YJ, Zhao DX. 2013 ACCF/AHA Guideline for the Management of ST-Elevation Myocardial Infarction A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Journal Of The American College Of Cardiology 2012, 61: e78-e140. PMID: 23256914, DOI: 10.1016/j.jacc.2012.11.019.Peer-Reviewed Original ResearchAmerican Heart AssociationCardiologyClinical ProtocolsCoronary Artery BypassDiagnostic Techniques, CardiovascularDisease ManagementElectrocardiographyEmergency Medical ServicesEvidence-Based MedicineHumansMedication Therapy ManagementMyocardial InfarctionMyocardial ReperfusionPatient SelectionPercutaneous Coronary InterventionRisk AssessmentThrombolytic TherapyUnited States2013 ACCF/AHA Guideline for the Management of ST-Elevation Myocardial Infarction
O'Gara PT, Kushner FG, Ascheim DD, Casey DE, Chung MK, de Lemos JA, Ettinger SM, Fang JC, Fesmire FM, Franklin BA, Granger CB, Krumholz HM, Linderbaum JA, Morrow DA, Newby LK, Ornato JP, Ou N, Radford MJ, Tamis-Holland JE, Tommaso CL, Tracy CM, Woo YJ, Zhao DX, Anderson JL, Jacobs AK, Halperin JL, Albert NM, Brindis RG, Creager MA, DeMets D, Guyton RA, Hochman JS, Kovacs RJ, Kushner FG, Ohman EM, Stevenson WG, Yancy CW. 2013 ACCF/AHA Guideline for the Management of ST-Elevation Myocardial Infarction. Circulation 2012, 127: e362-e425. PMID: 23247304, DOI: 10.1161/cir.0b013e3182742cf6.Peer-Reviewed Original ResearchAmerican Heart AssociationCardiologyClinical ProtocolsDiagnostic Techniques, CardiovascularDisease ManagementElectrocardiographyEmergency Medical ServicesEvidence-Based MedicineHumansMedication Therapy ManagementMyocardial InfarctionMyocardial ReperfusionPatient SelectionPercutaneous Coronary InterventionRisk AssessmentThrombolytic TherapyUnited States
2009
Determinants of Cardiac Catheterization Use in Older Medicare Patients With Acute Myocardial Infarction
Ko DT, Ross JS, Wang Y, Krumholz HM. Determinants of Cardiac Catheterization Use in Older Medicare Patients With Acute Myocardial Infarction. Circulation Cardiovascular Quality And Outcomes 2009, 3: 54-62. PMID: 20123672, PMCID: PMC3024143, DOI: 10.1161/circoutcomes.109.858456.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAgedAged, 80 and overCardiac CatheterizationChi-Square DistributionComorbidityFemaleHemorrhageHospitalizationHumansLikelihood FunctionsLogistic ModelsMaleMedicareMyocardial InfarctionPatient SelectionPractice Patterns, Physicians'Risk AssessmentRisk FactorsSeverity of Illness IndexSex FactorsTime FactorsTreatment OutcomeUnited StatesConceptsAcute myocardial infarctionCardiac catheterization useCardiac catheterizationInappropriate indicationsAMI patientsAppropriate indicationsMyocardial infarctionRisk scoreCardiology/American Heart Association class IBaseline cardiovascular riskOlder Medicare patientsHigh-risk patientsDemographic factorsMore comorbiditiesCardiovascular riskOlder patientsMale sexProcedure indicationFemale sexMedicare patientsAmerican CollegeAMI admissionsMedicare feePatientsCatheterization2009 Focused Updates: ACC/AHA Guidelines for the Management of Patients With ST‐Elevation Myocardial Infarction (Updating the 2004 Guideline and 2007 Focused Update) and ACC/AHA/SCAI Guidelines on Percutaneous Coronary Intervention (Updating the 2005 Guideline and 2007 Focused Update)
Kushner FG, Hand M, Smith SC, King SB, Anderson JL, Antman EM, Bailey SR, Bates ER, Blankenship JC, Casey DE, Green LA, Jacobs AK, Hochman JS, Krumholz HM, Morrison DA, Ornato JP, Pearle DL, Peterson ED, Sloan MA, Whitlow PL, Williams DO. 2009 Focused Updates: ACC/AHA Guidelines for the Management of Patients With ST‐Elevation Myocardial Infarction (Updating the 2004 Guideline and 2007 Focused Update) and ACC/AHA/SCAI Guidelines on Percutaneous Coronary Intervention (Updating the 2005 Guideline and 2007 Focused Update). Catheterization And Cardiovascular Interventions 2009, 74: e25-e68. PMID: 19924773, DOI: 10.1002/ccd.22351.Peer-Reviewed Original ResearchClinical trial participation: are we studying the patients we are trying to treat?
Wang OJ, Krumholz HM. Clinical trial participation: are we studying the patients we are trying to treat? European Journal Of Heart Failure 2009, 11: 1021-1022. PMID: 19875402, DOI: 10.1093/eurjhf/hfp137.Peer-Reviewed Original ResearchElevated Admission Glucose and Mortality in Elderly Patients Hospitalized With Heart Failure
Kosiborod M, Inzucchi SE, Spertus JA, Wang Y, Masoudi FA, Havranek EP, Krumholz HM. Elevated Admission Glucose and Mortality in Elderly Patients Hospitalized With Heart Failure. Circulation 2009, 119: 1899-1907. PMID: 19332465, DOI: 10.1161/circulationaha.108.821843.Peer-Reviewed Original ResearchConceptsHeart failureAdmission glucoseElderly patientsDiabetes mellitusAdverse outcomesMultivariable Cox regression modelsAdmission glucose levelsElevated admission glucoseAcute myocardial infarctionCox regression modelCause mortalityMultivariable adjustmentEntire cohortGlucose controlMyocardial infarctionCardiovascular conditionsGlucose levelsLarge cohortElevated glucoseRepresentative cohortPatientsSignificant associationMortalityCohortMellitus
2008
ACC/AHA 2008 Statement on Performance Measurement and Reperfusion Therapy A Report of the ACC/AHA Task Force on Performance Measures (Work Group to Address the Challenges of Performance Measurement and Reperfusion Therapy)
Masoudi FA, Bonow RO, Brindis RG, Cannon CP, DeBuhr J, Fitzgerald S, Heidenreich PA, Ho KK, Krumholz HM, Leber C, Magid DJ, Nilasena DS, Rumsfeld JS, Smith SC, Wharton TP. ACC/AHA 2008 Statement on Performance Measurement and Reperfusion Therapy A Report of the ACC/AHA Task Force on Performance Measures (Work Group to Address the Challenges of Performance Measurement and Reperfusion Therapy). Journal Of The American College Of Cardiology 2008, 52: 2100-2112. PMID: 19056001, DOI: 10.1016/j.jacc.2008.10.013.Peer-Reviewed Original Research
2006
Risks Associated With Statin Therapy
Kashani A, Phillips CO, Foody JM, Wang Y, Mangalmurti S, Ko DT, Krumholz HM. Risks Associated With Statin Therapy. Circulation 2006, 114: 2788-2797. PMID: 17159064, DOI: 10.1161/circulationaha.106.624890.Peer-Reviewed Original ResearchConceptsCreatine kinase elevationStatin therapyTransaminase elevationClinical trialsStatin trialsAdverse eventsHigher statin dosesMajor statin trialsRandomized statin trialsReports of myalgiaRisk of myalgiaWithdrawal of therapySevere comorbid conditionsSmall excess riskSignificant absolute increaseEnglish-language reportsHepatic complicationsStatin monotherapyCardiovascular eventsStatin dosesMost patientsComorbid conditionsAbsolute riskExcess riskElectronic searchUnderrepresentation of Renal Disease in Randomized Controlled Trials of Cardiovascular Disease
Coca SG, Krumholz HM, Garg AX, Parikh CR. Underrepresentation of Renal Disease in Randomized Controlled Trials of Cardiovascular Disease. JAMA 2006, 296: 1377-1384. PMID: 16985230, DOI: 10.1001/jama.296.11.1377.Peer-Reviewed Original ResearchMeSH KeywordsCardiovascular DiseasesHumansKidney DiseasesPatient SelectionRandomized Controlled Trials as TopicConceptsChronic congestive heart failureCongestive heart failureRenal diseaseRenal functionHeart failureSubgroup analysisCardiovascular diseaseCardiology/American Heart Association guidelinesAmerican Heart Association guidelinesAldosterone system antagonistsBaseline renal functionHeart Association guidelinesCardiovascular disease trialsCurrent American CollegeRandomized Controlled TrialsAcute myocardial infarctionEffects of interventionsRepresentation of patientsOriginal articlesBaseline characteristicsCardiovascular mortalityPatient characteristicsControlled TrialsPrognostic featuresMyocardial infarctionA Taxonomy for Disease Management
Krumholz HM, Currie PM, Riegel B, Phillips CO, Peterson ED, Smith R, Yancy CW, Faxon DP. A Taxonomy for Disease Management. Circulation 2006, 114: 1432-1445. PMID: 16952985, DOI: 10.1161/circulationaha.106.177322.Peer-Reviewed Original ResearchMeSH KeywordsCardiologyCase ManagementClinical ProtocolsComorbidityDelivery of Health CareDepressionDiabetes MellitusDisease ManagementHeart FailureInterdisciplinary CommunicationMedicareModels, TheoreticalOutcome and Process Assessment, Health CarePatient Care ManagementPatient Care TeamPatient Education as TopicPatient SelectionRisk FactorsSocieties, MedicalTerminology as TopicConceptsDisease management programsDisease management interventionsHeart failureDisease managementHealthcare providersTerms heart failureLevel of comorbidityMedical resource utilizationHome-based programPatient-centered measuresSystematic MEDLINE searchDuration of exposureHealthcare delivery systemSecondary outcomesClinical outcomesPatient populationPostacute careCaregiver burdenMedication managementStudy protocolChronic carePatient outcomesPatient educationWriting groupManagement interventionsDoes Random Treatment Assignment Cause Harm to Research Participants?
Gross CP, Krumholz HM, Van Wye G, Emanuel EJ, Wendler D. Does Random Treatment Assignment Cause Harm to Research Participants? PLOS Medicine 2006, 3: e188. PMID: 16719548, PMCID: PMC1470665, DOI: 10.1371/journal.pmed.0030188.Peer-Reviewed Original ResearchConceptsClinical outcomesTreatment assignmentRCT participantsClinical trialsTrial participantsRandom treatment assignmentPrimary study outcomeMeeting eligibility criteriaImproved patient outcomesSimilar health statusSubstandard medical careBaseline characteristicsPatient groupPatient outcomesEligibility criteriaHealth outcomesHealth statusEligible manuscriptsMedical careSystematic reviewSame interventionClinical researchStudy outcomesOutcomesSignificant differencesThe Prospective Registry Evaluating Myocardial Infarction: Events and Recovery (PREMIER)—Evaluating the impact of myocardial infarction on patient outcomes
Spertus JA, Peterson E, Rumsfeld JS, Jones PG, Decker C, Krumholz H, Consortium C. The Prospective Registry Evaluating Myocardial Infarction: Events and Recovery (PREMIER)—Evaluating the impact of myocardial infarction on patient outcomes. American Heart Journal 2006, 151: 589-597. PMID: 16504619, DOI: 10.1016/j.ahj.2005.05.026.Peer-Reviewed Original ResearchConceptsHealth status outcomesMyocardial infarctionChart abstractionPostdischarge careMI carePatients' health status outcomesDetailed chart abstractionOutcomes of patientsHealth status characteristicsOne-month followPatient-centered interviewProspective registryLongitudinal careMedical historyPatient outcomesInpatient careUS CentersPatientsStatus outcomesNovel registryHealth statusQuality careInfarctionCarePREMIER study