2020
Performance of Temporal Artery Temperature Measurement in Ruling Out Fever: Implications for COVID-19 Screening
Haimovich AD, Taylor RA, Krumholz HM, Venkatesh AK. Performance of Temporal Artery Temperature Measurement in Ruling Out Fever: Implications for COVID-19 Screening. Journal Of General Internal Medicine 2020, 35: 3398-3400. PMID: 32930937, PMCID: PMC7491363, DOI: 10.1007/s11606-020-06205-2.Peer-Reviewed Original ResearchMeSH KeywordsBody TemperatureCOVID-19HumansROC CurveSARS-CoV-2Sensitivity and SpecificityTemporal ArteriesThermometers
2015
Development and Validation of an Algorithm to Identify Planned Readmissions From Claims Data
Horwitz LI, Grady JN, Cohen DB, Lin Z, Volpe M, Ngo CK, Masica AL, Long T, Wang J, Keenan M, Montague J, Suter LG, Ross JS, Drye EE, Krumholz HM, Bernheim SM. Development and Validation of an Algorithm to Identify Planned Readmissions From Claims Data. Journal Of Hospital Medicine 2015, 10: 670-677. PMID: 26149225, PMCID: PMC5459369, DOI: 10.1002/jhm.2416.Peer-Reviewed Original ResearchMeSH KeywordsAgedAlgorithmsFee-for-Service PlansHospitals, VoluntaryHumansInsurance Claim ReviewMedicarePatient ReadmissionSensitivity and SpecificityUnited StatesConceptsSame-hospital readmissionsNegative predictive valuePositive predictive valuePredictive valueReadmission measuresHospital-wide readmission measureGold standard chart reviewAdministrative claims-based algorithmDiagnostic cardiac catheterizationClaims-based algorithmLarge teaching centersAcute care hospitalsSmall community hospitalUnplanned readmissionChart reviewCardiac catheterizationScheduled careSpecificity 96.5Community hospitalReadmissionClaims dataCardiac devicesHealth systemTeaching centerPublic reporting
2011
Emphasizing Methods in Outcomes Research
Krumholz HM. Emphasizing Methods in Outcomes Research. Circulation Cardiovascular Quality And Outcomes 2011, 4: 137-139. PMID: 21406667, DOI: 10.1161/circoutcomes.111.960831.Peer-Reviewed Original Research
2010
Optimizing statin treatment for primary prevention of coronary artery disease.
Hayward RA, Krumholz HM, Zulman DM, Timbie JW, Vijan S. Optimizing statin treatment for primary prevention of coronary artery disease. Annals Of Internal Medicine 2010, 152: 69-77. PMID: 20083825, DOI: 10.7326/0003-4819-152-2-201001190-00004.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedCholesterol, LDLClinical Trials as TopicComputer SimulationCoronary Artery DiseaseDrug Administration ScheduleFemaleGuideline AdherenceHumansHydroxymethylglutaryl-CoA Reductase InhibitorsMaleMiddle AgedPrimary PreventionQuality-Adjusted Life YearsRisk FactorsSensitivity and SpecificityTreatment OutcomeConceptsHigh-dose statinsQuality Enhancement Research InitiativeStatin therapyMore QALYsNational Cholesterol Education Program III guidelinesTreatment approachesCoronary artery disease preventionVeterans Affairs Health Services ResearchDoses of statinsCoronary artery diseaseRisk factor dataAvailable clinical dataYears of treatmentTarget approachBase-case analysisHealth services researchPersons 75 yearsStatin doseStatin trialsCAD eventsStatin treatmentArtery diseaseCAD riskPrimary preventionMyocardial infarction
2009
The Utility of Shorter Epochs in Direct Motion Monitoring
Dorsey K, Herrin J, Krumholz H, Irwin M. The Utility of Shorter Epochs in Direct Motion Monitoring. Research Quarterly For Exercise And Sport 2009, 80: 460-468. PMID: 19791632, PMCID: PMC3152374, DOI: 10.1080/02701367.2009.10599584.Peer-Reviewed Original Research
2008
Statistical Models and Patient Predictors of Readmission for Heart Failure: A Systematic Review
Ross JS, Mulvey GK, Stauffer B, Patlolla V, Bernheim SM, Keenan PS, Krumholz HM. Statistical Models and Patient Predictors of Readmission for Heart Failure: A Systematic Review. JAMA Internal Medicine 2008, 168: 1371-1386. PMID: 18625917, DOI: 10.1001/archinte.168.13.1371.Peer-Reviewed Original ResearchMeSH KeywordsDisease ProgressionEvidence-Based MedicineFemaleHeart FailureHospitalizationHumansIncidenceMaleModels, StatisticalPatient ReadmissionPredictive Value of TestsProportional Hazards ModelsQuality-Adjusted Life YearsRisk FactorsSensitivity and SpecificitySeverity of Illness IndexSurvival AnalysisUnited StatesConceptsPatient characteristicsPatient readmission riskReadmission riskPatient riskSystematic reviewReadmission ratesHospital ratesOvid Evidence-Based Medicine ReviewsEligible English-language publicationsEvidence-Based Medicine ReviewsHeart failure hospitalizationPatient risk stratificationEnglish-language literatureEnglish-language publicationsFailure hospitalizationHF hospitalizationAdult patientsHeart failureHospital readmissionMedicine ReviewsRisk stratificationPatient predictorsInclusion criteriaReadmissionCombined outcomeGlucometrics in Patients Hospitalized With Acute Myocardial Infarction
Kosiborod M, Inzucchi SE, Krumholz HM, Xiao L, Jones PG, Fiske S, Masoudi FA, Marso SP, Spertus JA. Glucometrics in Patients Hospitalized With Acute Myocardial Infarction. Circulation 2008, 117: 1018-1027. PMID: 18268145, DOI: 10.1161/circulationaha.107.740498.Peer-Reviewed Original Research2007 Focused Update of the ACC/AHA 2004 Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction
Antman E, Hand M, Armstrong P, Bates E, Green L, Halasyamani L, Hochman J, Krumholz H, Lamas G, Mullany C, Pearle D, Sloan M, Smith S, Anbe D, Kushner F, Ornato J, Pearle D, Sloan M, Jacobs A, Adams C, Anderson J, Buller C, Creager M, Ettinger S, Halperin J, Hunt S, Lytle B, Nishimura R, Page R, Riegel B, Tarkington L, Yancy C. 2007 Focused Update of the ACC/AHA 2004 Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction. Journal Of The American College Of Cardiology 2008, 51: 210-247. PMID: 18191746, DOI: 10.1016/j.jacc.2007.10.001.Peer-Reviewed Original Research
2006
Prediction of medical morbidity and mortality after acute myocardial infarction in patients at increased psychosocial risk in the Enhancing Recovery in Coronary Heart Disease Patients (ENRICHD) study
Jaffe AS, Krumholz HM, Catellier DJ, Freedland KE, Bittner V, Blumenthal JA, Calvin JE, Norman J, Sequeira R, O'Connor C, Rich MW, Sheps D, Wu C, Investigators F. Prediction of medical morbidity and mortality after acute myocardial infarction in patients at increased psychosocial risk in the Enhancing Recovery in Coronary Heart Disease Patients (ENRICHD) study. American Heart Journal 2006, 152: 126-135. PMID: 16824842, DOI: 10.1016/j.ahj.2005.10.004.Peer-Reviewed Original ResearchConceptsPost-MI patientsAcute myocardial infarctionMyocardial infarctionLow social supportCardiovascular mortalityEnd pointNonfatal myocardial infarctionPrimary end pointSecondary end pointsLong-term mortalityPrior myocardial infarctionSignificant multivariable predictorsProportional hazards modelSocial supportKillip classCause mortalityElevated creatinineRecurrent infarctionAdverse eventsBaseline characteristicsBypass surgeryEjection fractionHeart failureMedical morbidityMedical predictorsHow useful is computed tomography for screening for coronary artery disease? Screening for coronary artery disease with electron-beam computed tomography is not useful.
Chen J, Krumholz HM. How useful is computed tomography for screening for coronary artery disease? Screening for coronary artery disease with electron-beam computed tomography is not useful. Circulation 2006, 113: 125-46; discussion 125-46. PMID: 16400723.Peer-Reviewed Original Research
2005
Monitoring clinical changes in patients with heart failure: A comparison of methods
Spertus J, Peterson E, Conard MW, Heidenreich PA, Krumholz HM, Jones P, McCullough PA, Pina I, Tooley J, Weintraub WS, Rumsfeld JS, Consortium F. Monitoring clinical changes in patients with heart failure: A comparison of methods. American Heart Journal 2005, 150: 707-715. PMID: 16209970, DOI: 10.1016/j.ahj.2004.12.010.Peer-Reviewed Original ResearchMeSH KeywordsDiagnostic Tests, RoutineFemaleFollow-Up StudiesHeart FailureHumansMaleMiddle AgedProspective StudiesSensitivity and SpecificitySurveys and QuestionnairesTime FactorsConceptsClinical changesHeart failureWalk testNew York Heart AssociationHeart failure measuresHealth status instrumentsHighest c-statisticClinical deteriorationWalk distanceClinical statusPatient weightC-statisticHeart AssociationExercise testKCCQIndividual patientsNYHAPatientsDisease statusFunctional classClinical medicineLarge improvementStatusDeteriorationOutpatients
2003
Improving diagnostic testing and reducing overuse of antibiotics for children with pharyngitis: a useful role for the electronic medical record
BENIN AL, VITKAUSKAS G, THORNQUIST E, SHIFFMAN RN, CONCATO J, KRUMHOLZ HM, SHAPIRO ED. Improving diagnostic testing and reducing overuse of antibiotics for children with pharyngitis: a useful role for the electronic medical record. The Pediatric Infectious Disease Journal 2003, 22: 1043-1047. PMID: 14688562, DOI: 10.1097/01.inf.0000100577.76542.af.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnti-Bacterial AgentsChildChild, PreschoolDiagnostic Tests, RoutineDrug Resistance, MultipleDrug UtilizationElectronic Data ProcessingFemaleHumansLogistic ModelsMalePharyngitisProbabilityRegistriesRetrospective StudiesRisk AssessmentSensitivity and SpecificitySeverity of Illness IndexStatistics, NonparametricConceptsElectronic medical recordsOveruse of antibioticsDiagnostic testingMedical recordsEpisode of pharyngitisPediatric outpatient settingProportion of episodesOutpatient settingAntibiotic useScarlet feverPharyngitisChildren 3Diagnostic testsPatientsAntibioticsAppropriate useCliniciansWeeksEpisodesOveruseUseful rolePrescribingFeverClinicTestingWorsening renal function: What is a clinically meaningful change in creatinine during hospitalization with heart failure?
Smith GL, Vaccarino V, Kosiborod M, Lichtman JH, Cheng S, Watnick SG, Krumholz HM. Worsening renal function: What is a clinically meaningful change in creatinine during hospitalization with heart failure? Journal Of Cardiac Failure 2003, 9: 13-25. PMID: 12612868, DOI: 10.1054/jcaf.2003.3.Peer-Reviewed Original ResearchMeSH KeywordsAgedBiomarkersCohort StudiesConnecticutCreatinineFemaleFollow-Up StudiesHeart FailureHospitalizationHumansKidney DiseasesKidney Function TestsMaleMiddle AgedMultivariate AnalysisPredictive Value of TestsProspective StudiesRisk FactorsSensitivity and SpecificityStatistics as TopicStroke VolumeSurvival AnalysisConceptsCreatinine elevationRenal functionHeart failureAdverse outcomesRisk of deathNumber of patientsMagnitude of riskBaseline creatinineProspective cohortRisk factorsFunctional declineHigh riskPatientsCreatinineMortalityHospitalizationDeathDlImportant predictorRiskElevationMeaningful changeMaximum specificityOutcomesBetter definition
2002
The prognostic importance of different definitions of worsening renal function in congestive heart failure
Gottlieb SS, Abraham W, Butler J, Forman DE, Loh E, Massie BM, O'Connor CM, Rich MW, Stevenson LW, Young J, Krumholz HM. The prognostic importance of different definitions of worsening renal function in congestive heart failure. Journal Of Cardiac Failure 2002, 8: 136-141. PMID: 12140805, DOI: 10.1054/jcaf.2002.125289.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCreatinineFemaleHeart FailureHospital MortalityHumansLength of StayMaleMiddle AgedPrognosisRenal InsufficiencyROC CurveSensitivity and SpecificityTime FactorsConceptsCongestive heart failureRenal functionLength of stayHeart failurePrognostic importanceDepressed ejection fractionProlonged hospital stayFinal creatinineHospital mortalityHospital stayRenal failureSerum creatinineDL increaseEjection fractionACE inhibitorsPoor prognosisPatient populationWorse outcomesPrior historyTherapeutic interventionsCreatinineStayPatientsMortalityDl
2000
Impact of Smoking on Health-Related Quality of Life After Percutaneous Coronary Revascularization
Taira D, Seto T, Ho K, Krumholz H, Cutlip D, Berezin R, Kuntz R, Cohen D. Impact of Smoking on Health-Related Quality of Life After Percutaneous Coronary Revascularization. Circulation 2000, 102: 1369-1374. PMID: 10993854, DOI: 10.1161/01.cir.102.12.1369.Peer-Reviewed Original ResearchConceptsGeneral health perceptionSmoking statusHealth perceptionMedical Outcomes Study SF-36 questionnaireSymptomatic coronary artery diseaseMental healthRole-physical functioningImpact of smokingLate myocardial infarctionHealth-related qualityPercutaneous coronary revascularizationSF-36 questionnaireCoronary artery diseaseMulticenter clinical trialTime of PTCAQuality of lifeHRQoL improvementContinued smokingCoronary revascularizationBaseline characteristicsArtery diseaseIndex procedureSmoking cessationPhysical functionMyocardial infarctionAssociation of patients’ perception of health status and exercise electrocardiogram, myocardial perfusion imaging, and ventricular function measures
Mattera J, de Leon C, Wackers F, Williams C, Wang Y, Krumholz H. Association of patients’ perception of health status and exercise electrocardiogram, myocardial perfusion imaging, and ventricular function measures. American Heart Journal 2000, 140: 409-418. PMID: 10966538, DOI: 10.1067/mhj.2000.108518.Peer-Reviewed Original ResearchConceptsGeneral health perceptionHealth-related qualityPhysical functioningHealth perceptionMyocardial perfusion imagingHealth statusExercise testingPerfusion imagingMedical Outcomes Study Short Form SurveyPatients' health-related qualityShort Form SurveyAssociation of patientGeneral health statusImportant outcome measureSuccess of treatmentConsecutive patientsSF-36Metabolic equivalentsNoninvasive testingExercise testPatient outcomesIndividual patientsOutcome measuresForm SurveyPatient's viewpoint
1999
Exercise electrocardiography with right precordial leads.
Lauer MS, Cole C, Krumholz HM. Exercise electrocardiography with right precordial leads. New England Journal Of Medicine 1999, 341: 208; author reply 209. PMID: 10409040, DOI: 10.1056/nejm199907153410315.Peer-Reviewed Original ResearchBiasCoronary AngiographyCoronary DiseaseElectrocardiographyExercise TestHumansSensitivity and Specificity
1993
Cost-effectiveness of a smoking cessation program after myocardial infarction
Krumholz H, Cohen B, Tsevat J, Pasternak R, Weinstein M. Cost-effectiveness of a smoking cessation program after myocardial infarction. Journal Of The American College Of Cardiology 1993, 22: 1697-1702. PMID: 8227841, DOI: 10.1016/0735-1097(93)90598-u.Peer-Reviewed Original ResearchConceptsSmoking cessation programAcute myocardial infarctionNurse-managed smoking cessation programCessation programsMyocardial infarctionYears of lifeBeta-adrenergic antagonist therapyLife expectancyOne-way sensitivity analysesTwo-way sensitivity analysesCost-effective interventionHealth care resourcesAntagonist therapySmoking ratesInfarctionCare resourcesSmokersInterventionProgram costsYearsExpectancyTherapyLife
1992
Cost Effectiveness of Thrombolytic Therapy with Streptokinase in Elderly Patients with Suspected Acute Myocardial Infarction
Krumholz H, Pasternak R, Weinstein M, Friesinger G, Ridker P, Tosteson A, Goldman L. Cost Effectiveness of Thrombolytic Therapy with Streptokinase in Elderly Patients with Suspected Acute Myocardial Infarction. New England Journal Of Medicine 1992, 327: 7-13. PMID: 1598117, DOI: 10.1056/nejm199207023270102.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionThrombolytic therapyRisk of deathMyocardial infarctionElderly patientsPatients 75 yearsST-segment elevationOnset of symptomsUse of streptokinaseOne-way sensitivity analysesDecision analytic modelYears of lifeCost-effective treatmentRelative reductionHospital deathStreptokinase therapyOlder patientsClinical circumstancesThrombolytic agentsInfarctionPatientsCost effectivenessTherapyLack of consensusStreptokinase