Prevalence, Predictors, and Outcomes of Premature Discontinuation of Thienopyridine Therapy After Drug-Eluting Stent Placement
Spertus JA, Kettelkamp R, Vance C, Decker C, Jones PG, Rumsfeld JS, Messenger JC, Khanal S, Peterson ED, Bach RG, Krumholz HM, Cohen DJ. Prevalence, Predictors, and Outcomes of Premature Discontinuation of Thienopyridine Therapy After Drug-Eluting Stent Placement. Circulation 2006, 113: 2803-2809. PMID: 16769908, DOI: 10.1161/circulationaha.106.618066.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAngioplasty, Balloon, CoronaryCardiovascular AgentsCause of DeathClopidogrelCombined Modality TherapyCoronary RestenosisDrug Administration ScheduleDrug ImplantsFemaleFollow-Up StudiesHospitalizationHumansLife TablesMaleMiddle AgedMortalityMyocardial InfarctionPatient Education as TopicPlatelet Aggregation InhibitorsPrevalenceProportional Hazards ModelsProspective StudiesPyridinesRegistriesSirolimusStentsSurvival AnalysisThrombosisTiclopidineTreatment OutcomeTreatment RefusalConceptsDrug-eluting stentsThienopyridine therapyMI patientsMyocardial infarctionCardiac rehabilitation referralUse of thienopyridinesAcute myocardial infarctionPremature discontinuationDES placementRehabilitation referralHospitalization ratesStent thrombosisDischarge instructionsStent placementCardiovascular diseaseSubsequent mortalityPatientsDES treatmentTherapyHealth careMonthsThienopyridinesMortalityPrevalenceDaysHydroxymethylglutaryl‐CoA Reductase Inhibitors in Older Persons with Acute Myocardial Infarction: Evidence for an Age–Statin Interaction
Foody JM, Rathore SS, Galusha D, Masoudi FA, Havranek EP, Radford MJ, Krumholz HM. Hydroxymethylglutaryl‐CoA Reductase Inhibitors in Older Persons with Acute Myocardial Infarction: Evidence for an Age–Statin Interaction. Journal Of The American Geriatrics Society 2006, 54: 421-430. PMID: 16551308, PMCID: PMC2797316, DOI: 10.1111/j.1532-5415.2005.00635.x.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAged, 80 and overAtorvastatinCholesterol, LDLDrug PrescriptionsFatty Acids, MonounsaturatedFemaleFluvastatinFollow-Up StudiesHeptanoic AcidsHumansHydroxymethylglutaryl-CoA Reductase InhibitorsIndolesLovastatinMaleMyocardial InfarctionOdds RatioPravastatinPyridinesPyrrolesRetrospective StudiesSurvival RateTreatment OutcomeConceptsAcute myocardial infarctionHydroxymethylglutaryl-CoA reductase inhibitorsStatin therapyMyocardial infarctionLower mortalityOlder personsReductase inhibitorsPrincipal discharge diagnosisAcute care hospitalsCause mortalityEligible patientsOlder patientsYounger patientsCare hospitalDischarge prescriptionsPrimary outcomeDischarge diagnosisHospital characteristicsEfficacy dataMedicare patientsMultivariable modelObservational studyPatientsStatinsDischarge statins