2020
Newly diagnosed diabetes and outcomes after acute myocardial infarction in young adults
Ding Q, Spatz ES, Lipska KJ, Lin H, Spertus JA, Dreyer RP, Whittemore R, Funk M, Bueno H, Krumholz HM. Newly diagnosed diabetes and outcomes after acute myocardial infarction in young adults. Heart 2020, 107: 657-666. PMID: 33082173, PMCID: PMC8005796, DOI: 10.1136/heartjnl-2020-317101.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionHealth statusDischarge diagnosisPharmacological treatmentMyocardial infarctionShort-term health statusYoung AMI Patients (VIRGO) studyDisease-specific health statusYoung adultsQuality of lifeHospital complicationsHospital mortalityMedication initiationBaseline characteristicsClinical outcomesDiabetesPatientsDiagnosisPatient studiesMonthsComplicationsInfarctionSignificant differencesOutcomesMortality
2019
Application of the VIRGO taxonomy to differentiate acute myocardial infarction in young women
Sciria CT, Dreyer RP, D'Onofrio G, Safdar B, Krumholz HM, Spatz ES. Application of the VIRGO taxonomy to differentiate acute myocardial infarction in young women. International Journal Of Cardiology 2019, 288: 5-11. PMID: 31031078, DOI: 10.1016/j.ijcard.2019.03.054.Peer-Reviewed Original ResearchConceptsCoronary artery diseaseCardiac catheterizationYoung womenNon-obstructive coronary artery diseaseSingle-center retrospective chart reviewYoung AMI Patients (VIRGO) studyObstructive coronary artery diseaseRetrospective chart reviewAcute myocardial infarctionProportion of womenUniversal definitionIndex admissionChart reviewArtery diseaseConsecutive womenMyocardial infarctionTreatment strategiesCatheterizationMore young womenType 2Type 1Class IType 4BWomenPatient studies
2016
Gender differences in physical activity following acute myocardial infarction in adults: A prospective, observational study
Minges KE, Strait KM, Owen N, Dunstan DW, Camhi SM, Lichtman J, Geda M, Dreyer RP, Bueno H, Beltrame JF, Curtis JP, Krumholz HM. Gender differences in physical activity following acute myocardial infarction in adults: A prospective, observational study. European Journal Of Preventive Cardiology 2016, 24: 192-203. PMID: 27885060, DOI: 10.1177/2047487316679905.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAustraliaCardiac RehabilitationChi-Square DistributionExerciseExercise TherapyFemaleHealth BehaviorHealth Knowledge, Attitudes, PracticeHumansMaleMiddle AgedMyocardial InfarctionOdds RatioPatient ComplianceProspective StudiesRisk FactorsSex FactorsSpainTime FactorsTreatment OutcomeUnited StatesYoung AdultConceptsAcute myocardial infarctionPost-acute myocardial infarctionMyocardial infarctionPhysical activityRegular physical activity participationYoung AMI Patients (VIRGO) studyPhysical activity recommendationsAmerican Heart AssociationPhysical activity trajectoriesNon-white raceMyocardial infarction recoveryPhysical activity participationGender differencesHospital dischargeHeart AssociationLifestyle behaviorsActivity recommendationsObservational studyInfarctionAustralian hospitalsTargeted interventionsOne monthPatientsTime pointsLonger durationSexual Activity and Function in the Year After an Acute Myocardial Infarction Among Younger Women and Men in the United States and Spain
Lindau ST, Abramsohn E, Bueno H, D’Onofrio G, Lichtman JH, Lorenze NP, Sanghani RM, Spatz ES, Spertus JA, Strait KM, Wroblewski K, Zhou S, Krumholz HM. Sexual Activity and Function in the Year After an Acute Myocardial Infarction Among Younger Women and Men in the United States and Spain. JAMA Cardiology 2016, 1: 754-764. PMID: 27579897, PMCID: PMC5459405, DOI: 10.1001/jamacardio.2016.2362.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionSexual function problemsSexual activityMyocardial infarctionYoung AMI Patients (VIRGO) studyYoung womenSexual problemsModifiable risk factorsLogistic regression analysisMultinomial logistic regression analysisPrevalent sexual problemPhysician counselingMedian ageMost young adultsSexual functionRisk factorsSpanish hospitalsMAIN OUTCOMEErectile difficultiesFirst monthYoung adultsTime pointsWomenMore womenPatient studiesReturn to Work After Acute Myocardial Infarction
Dreyer RP, Xu X, Zhang W, Du X, Strait KM, Bierlein M, Bucholz EM, Geda M, Fox J, D'Onofrio G, Lichtman JH, Bueno H, Spertus JA, Krumholz HM. Return to Work After Acute Myocardial Infarction. Circulation Cardiovascular Quality And Outcomes 2016, 9: s45-s52. PMID: 26908859, PMCID: PMC4771977, DOI: 10.1161/circoutcomes.115.002611.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionMyocardial infarctionYoung AMI Patients (VIRGO) studyPrevious coronary diseaseYoung populationPatients' sociodemographic characteristicsSex differencesMedical record abstractionMultivariable regression analysisCoronary diseasePatient characteristicsYounger patientsRecord abstractionPatient interviewsHealth characteristicsPsychosocial factorsWorse recoverySociodemographic characteristicsHealth measuresGreater riskYoung womenPhysical healthPatient studiesHigher likelihoodYoung men
2015
The Variation in Recovery
Spatz ES, Curry LA, Masoudi FA, Zhou S, Strait KM, Gross CP, Curtis JP, Lansky AJ, Soares Barreto-Filho JA, Lampropulos JF, Bueno H, Chaudhry SI, D'Onofrio G, Safdar B, Dreyer RP, Murugiah K, Spertus JA, Krumholz HM. The Variation in Recovery. Circulation 2015, 132: 1710-1718. PMID: 26350057, PMCID: PMC4858327, DOI: 10.1161/circulationaha.115.016502.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge of OnsetAlgorithmsAortic DissectionClassificationCoronary DiseaseDiagnostic Techniques, CardiovascularFemaleHumansMaleMedical RecordsMiddle AgedMyocardial InfarctionMyocardiumOxygen ConsumptionPhenotypePlaque, AtheroscleroticProspective StudiesReproducibility of ResultsRisk FactorsSex FactorsTreatment OutcomeYoung AdultConceptsAcute myocardial infarctionCoronary artery diseaseArtery diseaseClinical phenotypeNonobstructive coronary artery diseaseYoung AMI Patients (VIRGO) studyObstructive coronary artery diseaseYoung womenType 2 acute myocardial infarctionBiological disease mechanismsSubset of patientsThird universal definitionUnique clinical phenotypeCulprit lesionClinical characteristicsMyocardial infarctionTherapeutic efficacyUniversal definitionStudy participantsPatientsSupply-demand mismatchYoung adultsDisease mechanismsPatient studiesCurrent classification schemesDepressive Symptoms in Younger Women and Men With Acute Myocardial Infarction: Insights From the VIRGO Study
Smolderen KG, Strait KM, Dreyer RP, D'Onofrio G, Zhou S, Lichtman JH, Geda M, Bueno H, Beltrame J, Safdar B, Krumholz HM, Spertus JA. Depressive Symptoms in Younger Women and Men With Acute Myocardial Infarction: Insights From the VIRGO Study. Journal Of The American Heart Association 2015, 4: e001424. PMID: 25836055, PMCID: PMC4579927, DOI: 10.1161/jaha.114.001424.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionDepressive symptomsLifetime historyMyocardial infarctionRisk factorsYoung acute myocardial infarctionYoung AMI Patients (VIRGO) studyMore cardiovascular risk factorsYoung womenCardiovascular risk factorsTime of admissionAdverse medical outcomesMore depressive symptomsLow socioeconomic profileAMI severityVIRGO StudyCardiovascular riskChart abstractionYounger patientsClinical profileRelevant sex differencesPatient profilesAMI admissionsMedical outcomesPatientsSex Differences in Reperfusion in Young Patients With ST-Segment–Elevation Myocardial Infarction
D'Onofrio G, Safdar B, Lichtman JH, Strait KM, Dreyer RP, Geda M, Spertus JA, Krumholz HM. Sex Differences in Reperfusion in Young Patients With ST-Segment–Elevation Myocardial Infarction. Circulation 2015, 131: 1324-1332. PMID: 25792558, PMCID: PMC4652789, DOI: 10.1161/circulationaha.114.012293.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionMyocardial infarctionReperfusion therapyAcute ST-segment elevation myocardial infarctionProspective observational cohort studyYoung AMI Patients (VIRGO) studyTime guidelinesYoung womenObservational cohort studyProportion of patientsElevation myocardial infarctionPercutaneous coronary interventionYears of ageSex differencesPatients 18Reperfusion strategyCohort studyCoronary interventionFibrinolytic therapyNeedle timeYounger patientsReperfusion delayRatio of womenReperfusion guidelinesSex disparities
2014
Sexual Activity and Counseling in the First Month After Acute Myocardial Infarction Among Younger Adults in the United States and Spain
Lindau ST, Abramsohn EM, Bueno H, D'Onofrio G, Lichtman JH, Lorenze NP, Mehta Sanghani R, Spatz ES, Spertus JA, Strait K, Wroblewski K, Zhou S, Krumholz HM. Sexual Activity and Counseling in the First Month After Acute Myocardial Infarction Among Younger Adults in the United States and Spain. Circulation 2014, 130: 2302-2309. PMID: 25512442, PMCID: PMC4322946, DOI: 10.1161/circulationaha.114.012709.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAge FactorsCounselingFemaleHumansLongitudinal StudiesMaleMiddle AgedMyocardial InfarctionPhysician-Patient RelationsProspective StudiesRisk AssessmentSex FactorsSexual BehaviorSexual Dysfunction, PhysiologicalSexual Dysfunctions, PsychologicalSpainUnited StatesYoung AdultConceptsAcute myocardial infarctionSexual activityMyocardial infarctionPatient experienceYoung AMI Patients (VIRGO) studyBaseline sexual activityPhysicians counsel patientsRisk-adjusted analysisMen ages 18Sample of womenPhysician counselingCounsel patientsMedian ageSociety guidelinesFemale genderHeart rateSexual inactivityU.S. womenAge 18First monthPatientsYoung adultsPatient studiesCounselingWomenEffect of Low Perceived Social Support on Health Outcomes in Young Patients With Acute Myocardial Infarction: Results From the Variation in Recovery: Role of Gender on Outcomes of Young AMI Patients (VIRGO) Study
Bucholz EM, Strait KM, Dreyer RP, Geda M, Spatz ES, Bueno H, Lichtman JH, D'Onofrio G, Spertus JA, Krumholz HM. Effect of Low Perceived Social Support on Health Outcomes in Young Patients With Acute Myocardial Infarction: Results From the Variation in Recovery: Role of Gender on Outcomes of Young AMI Patients (VIRGO) Study. Journal Of The American Heart Association 2014, 3: e001252. PMID: 25271209, PMCID: PMC4323798, DOI: 10.1161/jaha.114.001252.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionYoung AMI Patients (VIRGO) studyLow social supportQuality of lifeDepressive symptomsHealth statusYounger patientsMyocardial infarctionHealth outcomesENRICHD Social Support InventoryLow Perceived Social SupportSocial supportDepressive symptoms 12 monthsBaseline health statusLower functional statusWorse physical functioningWorse health statusPatient studiesSymptoms 12 monthsLower mental functioningMore depressive symptomsMultivariable adjustmentSocial Support InventoryAMI patientsFunctional status